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Insulin-like growth factor 1 and muscle growth: implication for satellite cell proliferation

Published online by Cambridge University Press:  05 March 2007

Shuichi Machida
Affiliation:
Department of Biomedical Sciences and the Dalton Cardiovascular Center, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA
Frank W. Booth*
Affiliation:
Department of Biomedical Sciences and the Dalton Cardiovascular Center, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA Department of Medical Pharmacology and Physiology and the Dalton Cardiovascular Center, University of Missouri-Columbia, E102 Veterinary Medical Building, 1600 East Rollins Road, Columbia, MO 65211, USA
*
*Corresponding author: Dr Frank W. Booth Fax: +1 573 884 6890, Email: boothf@missouri.edu
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Abstract

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Insulin-like growth factor 1 (IGF-1) has been shown to rescue the aging-related or inactivity-induced loss of muscle mass through the activation of satellite cells. However, the signalling pathways and the mechanism by which IGF-1 affects satellite cells have not been not completely identified. The purpose of the present review is to provide current understanding of the cellular and molecular events underlying IGF-1 induced proliferation of satellite cells.

Type
Symposium 5: Muscle hypertrophy: the signals of insulin, amino acids and exercise
Copyright
Copyright © The Nutrition Society 2004

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