Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-23T12:54:42.663Z Has data issue: false hasContentIssue false
  • English
  • Français

Influence of NRGN rs12807809 polymorphism on symptom severity in individuals with schizophrenia in the Han population but not the Zhuang population of south China

Published online by Cambridge University Press:  05 March 2015

Li Su ,
Jianxiong Long ,
Runde Pan ,
Xinfeng Xie ,
Xixiang Mao ,
Yang Zhou ,
Qiang Chen  and
Bo Wei
Li Su
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Jianxiong Long
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Runde Pan
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, China
Xinfeng Xie
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, China
Xixiang Mao
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, China
Yang Zhou
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
Qiang Chen*
Affiliation:
Guangxi Brain Hospital, Liuzhou, Guangxi, China
Bo Wei
Affiliation:
School of Public Health, Guangxi Medical University, Nanning, Guangxi, China
*
Qiang Chen, Guangxi Brain Hospital, Liuzhou, Guangxi, China.Tel: +860 772 311 5137; Fax: +860 772 311 5137; E-mail: gxchengqiang@163.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

NRGN is one of the most promising candidate genes for schizophrenia based on function and position. Therefore, this study aimed to examine the genetic association of this polymorphism with schizophrenia in the Zhuang and Han populations of south China.

Subjects and methods

A total of 282 patients (188 Han and 94 Zhuang) and 282 healthy subjects (188 Han and 94 Zhuang) were recruited. Of these, 246 schizophrenia patients underwent an assessment of psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS). A TaqMan genotyping assay method was used to determine the genotypes.

Results

We did not find a significant association of rs12807809 polymorphism with schizophrenia in the total pooled samples, or in the separate ethnic groups. However, in Han schizophrenia patients, quantitative data analyses showed that the CC genotype of the rs12807809 polymorphism was associated with PANSS aggression subscale score and activation subscale score. Furthermore, carriers of the C allele of rs12807809 polymorphism among Han schizophrenia patients had higher scores of general, activation, depression, aggression, and global symptoms than the T allele carriers.

Conclusion

In conclusion rs12807809 polymorphism may not contribute to the risk of schizophrenia but influence the clinical symptoms of schizophrenia in the Han population.

Keywords

NRGNpolymorphismrs12807809schizophrenia
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 27 , Issue 4 , August 2015 , pp. 221 - 227
Check for updates
Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

a

Co-first author

References

1.Saha, S, Chant, D, Welham, J, McGrath, J. A systematic review of the prevalence of schizophrenia. PLoS Med 2005;2:e141.CrossRefGoogle ScholarPubMed
2.Sullivan, PF, Kendler, KS, Neale, MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003;60:1187–1192.CrossRefGoogle ScholarPubMed
3.Sun, J, Kuo, PH, Riley, BP, Kendler, KS, Zhao, Z. Candidate genes for schizophrenia: a survey of association studies and gene ranking. Am J Med Genet B Neuropsychiatr Genet 2008;147B:1173–1181.CrossRefGoogle ScholarPubMed
4.Craddock, N, O’Donovan, MC, Owen, MJ. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull 2006;32:9–16.CrossRefGoogle ScholarPubMed
5.Stefansson, H, Ophoff, RA, Steinberg, Set al. Common variants conferring risk of schizophrenia. Nature 2009;460:744–747.CrossRefGoogle ScholarPubMed
6.Ran, X, Miao, HH, Sheu, FS, Yang, D. Structural and dynamic characterization of a neuron-specific protein kinase C substrate, neurogranin. Biochemistry 2003;42:5143–5150.CrossRefGoogle ScholarPubMed
7.Huang, KP, Huang, FL, Jager, T, Li, J, Reymann, KG, Balschun, D. Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. J Neurosci 2004;24:10660–10669.CrossRefGoogle ScholarPubMed
8.Hakak, Y, Walker, JR, Li, Cet al. Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A 2001;98:4746–4751.CrossRefGoogle ScholarPubMed
9.Ruano, D, Aulchenko, YS, Macedo, Aet al. Association of the gene encoding neurogranin with schizophrenia in males. J Psychiatr Res 2008;42:125–133.CrossRefGoogle ScholarPubMed
10.Betcheva, ET, Mushiroda, T, Takahashi, Aet al. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J Hum Genet 2009;54:98–107.CrossRefGoogle ScholarPubMed
11.Ohi, K, Hashimoto, R, Yasuda, Yet al. Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis. Am J Med Genet B Neuropsychiatry Genet 2012;159B:405–413.CrossRefGoogle ScholarPubMed
12.Li, T, Li, Z, Chen, Pet al. Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese. Biol Psychiatry 2010;68:671–673.CrossRefGoogle ScholarPubMed
13.Shen, YC, Tsai, HM, Cheng, MC, Hsu, SH, Chen, SF, Chen, CH. Genetic and functional analysis of the gene encoding neurogranin in schizophrenia. Schizophr Res 2012;137:7–13.CrossRefGoogle ScholarPubMed
14.Su, L, Wei, B, Chen, Qet al. Association study of PRODH gene variant rs385440 with schizophrenia in Zhuang and Han nationality of Guangxi Chinese. J Behav Med Brain Sci 2012;21:36–39.Google Scholar
15.Kay, SR, Fiszbein, A, Opler, LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261–276.CrossRefGoogle ScholarPubMed
16.Lindenmayer, JP, Grochowski, S, Hyman, RB. Five factor model of schizophrenia: replication across samples. Schizophr Res 1995;3:229–234.CrossRefGoogle Scholar
17.Gurling, HM, Kalsi, G, Brynjolfson, Jet al. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 2001;68:661–673.CrossRefGoogle Scholar
18.Cherlyn, SY, Woon, PS, Liu, JJ, Ong, WY, Tsai, GC, Sim, K. Genetic association studies of glutamate, GABA and related genes in schizophrenia and bipolar disorder: a decade of advance. Neurosci Biobehav Rev 2010;34:958–977.CrossRefGoogle ScholarPubMed
19.Kim, Y, Zerwas, S, Trace, SE, Sullivan, PF. Schizophrenia genetics: where next? Schizophr Bull 2011;37:456–463.CrossRefGoogle ScholarPubMed
20.Fanous, AH, Kendler, KS. Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework. Mol Psychiatry 2005;10:6–13.CrossRefGoogle ScholarPubMed
21.Li, W, Wang, X, Zhao, Jet al. Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. Genes Brain Behav 2012;11:87–93.CrossRefGoogle ScholarPubMed
22.Sun, YH, Shen, Y, Xu, Q. DTNBP1 gene is associated with some symptom factors of schizophrenia in Chinese Han nationality. Chin Med Sci J 2010;25:85–89.CrossRefGoogle ScholarPubMed
23.Chang, HA, Lu, RB, Shy, MJ, Chang, CC, Lee, MS, Huang, SY. Brain-derived neurotrophic factor Val66Met polymorphism: association with psychopathological symptoms of schizophrenia? J Neuropsychiatry Clin Neurosci 2009;21:30–37.CrossRefGoogle ScholarPubMed
24.Rethelyi, JM, Bakker, SC, Polgar, Pet al. Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample. Am J Med Genet B Neuropsychiatr Genet 2010;153B:792–801.CrossRefGoogle Scholar
25.Zhou, DH, Yan, QZ, Yan, XMet al. The study of BDNF Val66Met polymorphism in Chinese schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:930–933.CrossRefGoogle Scholar
26.Huang, FL, Huang, KP, Boucheron, C. Long-term enrichment enhances the cognitive behavior of the aging neurogranin null mice without affecting their hippocampal LTP. Learn Mem 2007;14:512–519.CrossRefGoogle ScholarPubMed
27.Krug, A, Krach, S, Jansen, Aet al. The effect of neurogranin on neural correlates of episodic memory encoding and retrieval. Schizophr Bull 2011;39:141–150.CrossRefGoogle ScholarPubMed
28.Bliss, TV, Collingridge, GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993;361:31–39.CrossRefGoogle ScholarPubMed