Hostname: page-component-8448b6f56d-dnltx Total loading time: 0 Render date: 2024-04-19T18:47:33.727Z Has data issue: false hasContentIssue false
  • English
  • Français

Oxidative stress index (OSi) as a new tool to assess redox status in dairy cattle during the transition period

Published online by Cambridge University Press:  19 March 2013

A. Abuelo ,
J. Hernández ,
J. L. Benedito  and
C. Castillo
A. Abuelo*
Affiliation:
Department of Animal Pathology, College of Veterinary Medicine, University of Santiago de Compostela, Campus Universitario, s/n – 27002 Lugo, Spain
J. Hernández
Affiliation:
Department of Animal Pathology, College of Veterinary Medicine, University of Santiago de Compostela, Campus Universitario, s/n – 27002 Lugo, Spain
J. L. Benedito
Affiliation:
Department of Animal Pathology, College of Veterinary Medicine, University of Santiago de Compostela, Campus Universitario, s/n – 27002 Lugo, Spain
C. Castillo
Affiliation:
Department of Animal Pathology, College of Veterinary Medicine, University of Santiago de Compostela, Campus Universitario, s/n – 27002 Lugo, Spain
*
†E-mail: angel.abuelo@usc.es
Get access

Abstract

Oxidative stress (OS) plays a key role in the initiation or progression of numerous diseases, and dairy cows undergo OS at the transition period. However, discrepancies between methodologies make it difficult to make comparisons between studies, and therefore research on this topic may not be implemented in farms. This study aims to test under field conditions the use of an oxidative stress index (OSi) as a combined measurement through a ratio between pro-oxidants and antioxidants throughout the transition period in dairy farms. Serum samples of high-yielding dairy cows were taken, and markers of oxidative damage and antioxidant capacity were measured in four different production stages: (i) late lactation (LL; −2 to −1 months); (ii) prepartum (PrP; −1 month until parturition); (iii) postpartum (PsP; delivery to +1 month); and (iv) peak of lactation (PkL; +1 to +2.5 months). Values were compared between production stages and against a metabolic baseline status (CTR, 4th to 5th month of gestation). To the best of our knowledge, this is the first report in the literature that discusses the values of these oxidative stress biomarkers (and the OS index) for cows with low metabolic demands, as to date most research in this area has focused on the transition period. With the joint evaluation through the OSi, differences were found that were not present with the separate evaluation of pro-oxidants or antioxidants, thus supporting our hypothesis that the OSi indicates more accurately the oxidative status of the animals. It was also confirmed that dairy cows undergo OS after parturition, and that antioxidant supplementation from 1 month before parturition until the peak of lactation may be needed to reduce the risk of OS.

Keywords

oxidative status, peripartum period, vitamin supplementation, dairy cow, antioxidants
Type
Behaviour, welfare and health
Information
animal , Volume 7 , Issue 8 , August 2013 , pp. 1374 - 1378
Copyright
Copyright © The Animal Consortium 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bernabucci, U, Ronchi, B, Lacetera, N, Nardone, A 2002. Markers of oxidative status in plasma and erythrocytes of transition dairy cows during hot season. Journal of Dairy Science 85, 2173–2179.CrossRefGoogle ScholarPubMed
Bernabucci, U, Ronchi, B, Lacetera, N, Nardone, A 2005. Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. Journal of Dairy Science 88, 2017–2026.CrossRefGoogle ScholarPubMed
Castillo, C, Hernández, J, Bravo, A, López-Alonso, M, Pereira, V, Benedito, JL 2005. Oxidative status during late pregnancy and early lactation in dairy cows. The Veterinary Journal 169, 286–292.Google Scholar
Castillo, C, Hernández, J, Valverde, I, Pereira, V, Sotillo, J, López Alonso, M, Benedito, JL 2006. Plasma malonaldehyde (MDA) and total antioxidant status (TAS) during lactation in dairy cows. Research in Veterinary Science 80, 133–139.Google Scholar
Celi, P 2011. Biomarkers of oxidative stress in ruminant medicine. Immunopharmacology and Immunotoxicology 33, 233–240.CrossRefGoogle ScholarPubMed
Dobbelaar, P, Bouwstra, RJ, Goselink, RMA, Jorritsma, R, van den Borne, JJGC, Jansen, EHJM 2010. Effects of vitamin E supplementation on and the association of body condition score with changes in peroxidative biomarkers and antioxidants around calving in dairy heifers. Journal of Dairy Science 93, 3103–3113.Google Scholar
Goff, JP, Horst, RL 1997. Physiological changes at parturition and their relationship to metabolic disorders. Journal of Dairy Science 80, 1260–1268.Google Scholar
Lykkesfeldt, J, Svendsen, O 2007. Oxidants and antioxidants in disease: oxidative stress in farm animals. The Veterinary Journal 173, 502–511.Google Scholar
Politis, I 2012. Reevaluation of vitamin E supplementation of dairy cows: bioavailability, animal health and milk quality. Animal 6, 1427–1434.CrossRefGoogle ScholarPubMed
Sharma, RK, Pasqualotto, FF, Nelson, DR, Thomas, AJ, Agarwal, A 1999. The reactive oxygen species vs total antioxidant capacity score is a new measure of oxidative stress to predict male infertility. Human Reproduction 14, 2801–2807.CrossRefGoogle Scholar
Trotti, R, Carratelli, M, Barbieri, M, Micieli, G, Bosone, D, Rondanelli, M, Bo, P 2001. Oxidative stress and a thrombophilic condition in alcoholics without severe liver disease. Haematologica 86, 85–91.Google Scholar
Wullepit, N, Raes, K, Beerda, B, Veerkamp, RF, Fremaut, D, De Smet, S 2009. Influence of management and genetic merit for milk yield on the oxidative status of plasma in heifers. Livestock Science 123, 276–282.Google Scholar