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The G allele in IL-10-1082 G/A may have a role in lowering the susceptibility to panic disorder in female patients

Published online by Cambridge University Press:  06 June 2016

Han-Joon Kim  and
Yong-Ku Kim
Han-Joon Kim
Affiliation:
Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea
Yong-Ku Kim*
Affiliation:
Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea
*
Prof. Dr. Yong-Ku Kim, Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, 123 Jeokgeum-ro, Danwon-gu, Ansan 152-703, Republic of Korea. Tel: +82-31-412-5138; Fax: +82-31-412-5132; E-mail: yongku@korea.ac.kr
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Abstract

Background

Immune system activation is involved in the pathophysiology of panic disorder (PD). We investigated INF-γ+874 A/T, TNF-α-308 G/A, and IL-10-1082 G/A single nucleotide polymorphisms (SNPs) to determine their association with PD.

Method

This study enroled 135 PD patients and 135 healthy controls. INF-γ+874 A/T (rs2430561), TNF-α-308 G/A (rs1800629), and IL-10-1082 G/A (rs1800896) were genotyped.

Results

There were no differences in genotypes or allele frequencies between the patient and control groups, regardless of accompanying agoraphobia. However, for female patients, the G allele frequency in IL-10 SNP was higher in the control group than in the patient group. Additionally, the female control group had a higher frequency of the A/G and G/G genotype in the IL-10 SNP than the female patient group.

Conclusion

We suggest that the G allele in IL-10-1082 G/A might have a role in reducing the manifestations of PD in female patients. Further studies are needed to extend and confirm our findings.

Keywords

cytokineIFN-rIL-10panic disorderTNF-α
Type
Short Communication
Information
Acta Neuropsychiatrica , Volume 28 , Issue 6 , December 2016 , pp. 357 - 361
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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