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FSH in therapy: physiological basis, new preparations and clinical use

Published online by Cambridge University Press:  03 June 2009

Manuela Simoni  and
Eberhard Nieschlag
Manuela Simoni
Affiliation:
Institute of Reproductive Medicine of the University, WHO Collaborating Center for Research in Human Reproduction, Münster, Germany
Eberhard Nieschlag*
Affiliation:
Institute of Reproductive Medicine of the University, WHO Collaborating Center for Research in Human Reproduction, Münster, Germany
*
Institute of Reproductive Medicine of the University, WHO Collaborating Center for Research in Human Reproduction, Steinfurterstrasse 107, D-48149 Münster, Germany.
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Extract

Follicle stimulating hormone (FSH) is a glycoprotein hormone secreted by the pituitary gland that, together with luteinizing hormone (LH), controls development, maturation and function of the gonad. Like the related hormones, LH, thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), FSH consists of two polypeptide chains, α and β, bearing carbohydrate moieties N-linked to asparagine (Asn) residues. The α subunit is common to all members of the glycoprotein hormone family, whereas the β subunit, although structurally very similar, differs in each hormone and confers specificity of action.

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Articles
Information
Reproductive Medicine Review , Volume 4 , Issue 3 , October 1995 , pp. 163 - 177
Copyright
Copyright © Cambridge University Press 1995

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