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Food antibodies in schizophrenia

Published online by Cambridge University Press:  09 July 2009

H. G. Kinnell*
Affiliation:
Botleys Park Hospital, Chertsey, Surrey, Western Infirmary, Glasgow
E. Kirkwood
Affiliation:
Botleys Park Hospital, Chertsey, Surrey, Western Infirmary, Glasgow
Catriona Lewis
Affiliation:
Botleys Park Hospital, Chertsey, Surrey, Western Infirmary, Glasgow
*
1Address for correspondence: Dr H. G. Kinnell, Botleys Park Hospital, Chertsey, Surrey KT16 0QA.

Synopsis

This study investigates the validity of the suggestion that food allergy is relevant to the manifestation of schizophrenic illness. Antibodies to oats, wheat, gluten, chicken, calf and milk protein were measured in 98 schizophrenics and in 90 unaffected close blood relatives. The majority of patients were male out-patients, and most were on neuroleptic medication. Antibodies were detected in only a minority of patients.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1982

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References

REFERENCES

Ashkenazi, A., Krasilowsky, D., Levin, S. & Idar, D. (1979). Immunologic reactions of psychotic patients to fractions of gluten. American Journal of Psychiatry 136, 13061309.Google Scholar
Astrachan, B. M., Harrow, M., Alder, D., Brauer, L., Schwartz, A., Schwartz, C. & Tucker, G. (1972). A checklist for the diagnosis of schizophrenia. British Journal of Psychiatry 121, 529539.Google Scholar
Burton, R. (1630). An Anatomy of Melancholy. Everyman: London (reprinted 1968).Google Scholar
Dean, G., Haniffy, L., Stevens, F. M., Temperley, L., O'Broin, J. D., Scott, J. & Cahalane, S. F. (1975). Schizophrenia and coeliac disease. Journal of the Irish Medical Association 68, 545546.Google ScholarPubMed
Denman, A. M. (1980). The relevance of immunopathology to research in schizophrenia. In Schizophrenia and Addiction (ed. Hemmings, G.), pp. 97109. MTP Press: Lancaster.CrossRefGoogle Scholar
Dohan, F. C. (1966 a). Wartime changes in hospital admissions for schizophrenia: a comparison of admission for schizophrenia and other psychoses in six countries during World War II. Acta psychiatrica scandinavica 42, 123.Google Scholar
Dohan, F. C. (1966 b). Cereals and schizophrenia: data and hypothesis. Acta psychiatrica scandinavica 42, 125152.Google Scholar
Dohan, F. C. (1970). Letter. Lancet i, 897898.Google Scholar
Dohan, F. C. & Grasberger, J. C. (1973). Relapsed schizophrenics: earlier discharge from the hospital after cereal-free, milk-free diet. American Journal of Psychiatry 130, 685688.CrossRefGoogle ScholarPubMed
Dohan, F. C., Grasberger, F. M., Lowell, H. T., Johnston, A. & Arbegast, W. (1969). Relapsed schizophrenics: more rapid improvement on a milk and cereal-free diet. British Journal of Psychiatry 115, 595596.CrossRefGoogle ScholarPubMed
Fessel, W. J. (1962). Blood proteins in functional psychoses. A review of the literature and unifying hypothesis. Archives of General Psychiatry 6, 132148.CrossRefGoogle ScholarPubMed
Hekkens, W. T. J. M. (1978). Antibodies to gliadin in serum of normals, coeliac patients and schizophrenics. In Biological Basis of Schizophrenia (ed. Hemmings, G. and Hemmings, W. A.), pp. 259261. MTP Press: Lancaster.Google Scholar
Hemmings, G. (1977). A New Approach to Schizophrenia. Schizophrenia Association of Great Britain: Caernarvon.Google Scholar
Hemmings, W. A. (1978). The absorption of large breakdown products of dietary proteins into the body tissues including brain. In Biological Basis of Schizophrenia (ed. Hemmings, G. and Hemmings, W. A.), pp. 239257. MTP Press: Lancaster.Google Scholar
Herbert, W. J. (1978). Passive haemaglutination. In Handbook of Experimental Immunology (ed. Weir, D. M.), chapter 20.Google Scholar
Hussar, A. E., Cradle, J. L. & Beiser, S. M. (1971). A study of the immunologic and allergic responsiveness of chronic schizophrenics. British Journal of Psychiatry 118, 9192.Google Scholar
Lancet (1976). Gluten and schizophrenia; i, 844.Google Scholar
Levy, D. L. & Weinreb, H. J. (1976). Letter. Science 194, 448.CrossRefGoogle Scholar
Lovett, L. C., Ulrich, T. J., Simms, B. G. & Goldstein, A. L. (1978). Birth defects. Original Article Series, Vol. 14, No. 5, pp. 407422. The National Foundation.Google Scholar
Mascord, I. & Freed, D. (1978). Antibodies to foodstuffs in schizophrenia. Letter. British Medical Journal ii, 1351.Google Scholar
Rice, J. R. (1978). Another look at gluten in schizophrenia. American Journal of Psychiatry 135, 14171418.Google Scholar
Singh, M. M. & Kay, S. R. (1976). Wheat gluten as a pathogenic factor in schizophrenia. Science, 191, 401402.CrossRefGoogle ScholarPubMed
Smith, J. M. (1976). Letter. Science 194, 448.Google Scholar
Stevens, F. M.,Lloyd, R. S., Geraghty, S. M. J., Reynolds, M. T. G., Sarsfield, M. J., McNicholl, B., Fottrell, P. R., Wright, R. & McCarthy, C. F. (1977). Schizophrenia and coeliac disease – the nature of the relationship. Psychological Medicine 7, 259263.Google Scholar
Zioudrou, C., Streaty, R. A. & Klee, W. A. (1979). Opioid peptides derived from food proteins. The exorphins. Journal of Biological Chemistry 254, 24462449.Google Scholar