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Exclusion of linkage of schizophrenia to the gene for the dopamine D2 receptor (DRD2) and chromosome 11q translocation sites

Published online by Cambridge University Press:  09 July 2009

G. Kalsi ,
B. S. Mankoo ,
D. Curtis ,
J. Brynjolfsson ,
T. Read ,
T. Sharma ,
P. Murphy ,
H. Petursson  and
H. M. D. Gurling
G. Kalsi
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
B. S. Mankoo
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
D. Curtis*
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
J. Brynjolfsson
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
T. Read
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
T. Sharma
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
P. Murphy
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
H. Petursson
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
H. M. D. Gurling
Affiliation:
Molecular Psychiatry Laboratory, Academic Department of Psychiatry, University College and Middlesex School of Medicine and the Genetics Section, Institute of Psychiatry, London; Department of Psychiatry, Borgarspitalinn, University of Iceland, Reykjavik, Iceland
*
1 Address for correspondence: Dr D. Curtis, Genetics Section, Institute of Psychiatry, De Crespigny Park, London SE5 8AF.
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Synopsis

There have been previous reports of a 1q43;11q21 translocation cosegregating with schizophrenia and a 9p22;11q22.3 translocation cosegregating with manic depression. In addition, the genes for the dopamine D2 receptor and for tyrosinase both map to chromosome 11q. Three 11q DNA markers were used to investigate 23 pedigrees containing multiple cases of schizophrenia. Strongly negative lod scores were obtained, providing evidence against linkage over a 70 cM region which included both translocation sites and both candidate genes.

Type
Original Articles
Information
Psychological Medicine , Volume 25 , Issue 3 , May 1995 , pp. 531 - 537
Copyright
Copyright © Cambridge University Press 1995

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