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Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder

Published online by Cambridge University Press:  20 January 2016

R. H. Jacobs ,
A. Barba ,
J. R. Gowins ,
H. Klumpp ,
L. M. Jenkins ,
B. J. Mickey ,
O. Ajilore ,
M. Peciña ,
M. Sikora  and
K. A. Ryan
...Show all authors
R. H. Jacobs
Affiliation:
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
A. Barba
Affiliation:
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
J. R. Gowins
Affiliation:
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
H. Klumpp
Affiliation:
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
L. M. Jenkins
Affiliation:
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
B. J. Mickey
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
O. Ajilore
Affiliation:
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
M. Peciña
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
M. Sikora
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
K. A. Ryan
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
D. T. Hsu
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA
R. C. Welsh
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA Department of Radiology, Molecular and Behavioral Neuroscience Institute, Ann Arbor, MI, USA
J.-K. Zubieta
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA Department of Radiology, Molecular and Behavioral Neuroscience Institute, Ann Arbor, MI, USA
K. L. Phan
Affiliation:
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA Mental Health Service Line, Jesse Brown VA Medical Center, Chicago, IL, USA
S. A. Langenecker*
Affiliation:
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA
*
*Address for correspondence: S. A. Langenecker, Ph.D., Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street, M/C 912, Chicago, IL 60612, USA. (Email: slangenecker@psych.uic.edu)
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Abstract

Background

Recent meta-analyses of resting-state networks in major depressive disorder (MDD) implicate network disruptions underlying cognitive and affective features of illness. Heterogeneity of findings to date may stem from the relative lack of data parsing clinical features of MDD such as phase of illness and the burden of multiple episodes.

Method

Resting-state functional magnetic resonance imaging data were collected from 17 active MDD and 34 remitted MDD patients, and 26 healthy controls (HCs) across two sites. Participants were medication-free and further subdivided into those with single v. multiple episodes to examine disease burden. Seed-based connectivity using the posterior cingulate cortex (PCC) seed to probe the default mode network as well as the amygdala and subgenual anterior cingulate cortex (sgACC) seeds to probe the salience network (SN) were conducted.

Results

Young adults with remitted MDD demonstrated hyperconnectivity of the left PCC to the left inferior frontal gyrus and of the left sgACC to the right ventromedial prefrontal cortex (PFC) and left hippocampus compared with HCs. Episode-independent effects were observed between the left PCC and the right dorsolateral PFC, as well as between the left amygdala and right insula and caudate, whereas the burden of multiple episodes was associated with hypoconnectivity of the left PCC to multiple cognitive control regions as well as hypoconnectivity of the amygdala to large portions of the SN.

Conclusions

This is the first study of a homogeneous sample of unmedicated young adults with a history of adolescent-onset MDD illustrating brain-based episodic features of illness.

Keywords

Amygdalaconnectivitydepressionfunctional magnetic resonance imagingillness course
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 5 , April 2016 , pp. 1055 - 1067
Copyright
Copyright © Cambridge University Press 2016 

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