Expert Reviews in Molecular Medicine:
Accession information: Vol. 5; 23 May 2003 Citation

Structure and interactions of C1q

Karen Francis, Johan van Beek, Cecile Canova, Jim W. Neal and Philippe Gasque

Author contact details

Figure 4. Structure and interactions of C1q. C1q is a key component of the classical complement pathway and acts as a recognition molecule that interacts with antibody–antigen complexes or nonimmune molecules to activate the complement cascade. C1q consists of six subunits, each with a collagen-like fibrous portion at its N-terminal and a globular head that is involved in binding to diverse targets. It has recently been determined that C1q may also opsonise damaged and dying cells, amyloid fibrils and myelin proteins, leading to their recognition and clearance (fig004pgc).

Expert Reviews in Molecular Medicine © Cambridge University Press ISSN 1462-3994 (Disclaimer and copyright)
Editorial Office: Centre for Applied Research in Educational Technologies (CARET), 1st Floor, 16 Mill Lane, Cambridge, CB2 1SB, UK. Tel: +44 (0)1223 765 375; Fax: +44(0)1223 765 505; E-mail: