Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 5; 23 May 2003 Citation
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Structure and interactions of C1q

Karen Francis, Johan van Beek, Cecile Canova, Jim W. Neal and Philippe Gasque

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Figure 4. Structure and interactions of C1q. C1q is a key component of the classical complement pathway and acts as a recognition molecule that interacts with antibody–antigen complexes or nonimmune molecules to activate the complement cascade. C1q consists of six subunits, each with a collagen-like fibrous portion at its N-terminal and a globular head that is involved in binding to diverse targets. It has recently been determined that C1q may also opsonise damaged and dying cells, amyloid fibrils and myelin proteins, leading to their recognition and clearance (fig004pgc).



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