Expert Reviews in Molecular Medicine: http://www.expertreviews.org/
Accession information: Vol. 5; 28 January 2003
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The natural killer (NK)-cell response to tumour cells

Roshni Mitra, Sarvjeet Singh and Ashok Khar

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Figure 3. The natural killer (NK)-cell response to tumour cells. NK cells kill tumour cells through mechanisms that involve: antibody (Ab)-dependent cellular cytotoxicity (ADCC), in which the Fc portion of an Ab bound to antigen (Ag) on the tumour cell surface binds to Fc receptor (FcR) on the NK cell; Fas (CD95)–Fas ligand (CD95L) interaction; and release of perforin and granzyme B molecules, which cause apoptosis/necrosis of the tumour cell (fig003akh).



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