Expert Reviews in Molecular Medicine:
Accession information: (01)00311-8h.htm (shortcode: fig002mgb); 14 May 2001
Reprint/PDF version

The roles of BRCA1 and BRCA2 in DNA repair

Meghan A. Arnold and Michael Goggins

Author contact details

Figure 2. The roles of BRCA1 and BRCA2 in DNA repair. (a) This model suggests that a macromolecular complex consisting of BRCA1, BRCA2, BARD1 and Rad51 functions to repair damaged DNA. Complex formation is preceded by phosphorylation of BRCA1 by the kinase ATM. In response to DNA damage, the complex relocates to chromosomal regions undergoing DNA replication marked by proliferating cell nuclear antigen (PCNA). (b) Loss of BRCA1 and/or BRCA2 function (indicated by dotted outlines) leads to inability to repair damaged DNA. When damage occurs to critical checkpoint genes, such as p53 (dotted outline), checkpoints such as p21 cannot be activated and cells proliferate. Modified figure reproduced, with permission from Elsevier Science, from Ref. 11 [Welcsh, P.L, Owens, K.N. and King, M.C. (2000) Insights into the functions of BRCA1 and BRCA2. Trends in Genetics 16, 69-74, PubMed] (fig002mgb).

Expert Reviews in Molecular Medicine Cambridge University Press ISSN 1462-3994 (Disclaimer and copyright)
Editorial Office: Centre for Applied Research in Educational Technologies (CARET), 1st Floor, 16 Mill Lane, Cambridge, CB2 1SB, UK. Tel: +44 (0)1223 765 375; Fax: +44(0)1223 765 505; E-mail: