Figure 7

Micro-transient activity in the isolated whole guinea pig bladder in the presence of atropine or tetrodotoxin. A, effects of a brief (100 s) exposure to 1 µM carbachol. This is followed by an application of atropine and a second exposure to carbachol during which there was no response, i.e. atropine totally inhibited the agonist-induced changes. The pressure micro-transients were unaffected by atropine. B, tetrodotoxin (2.5 µM) did not affect micro-transient activity. Ordinate, intravesical pressure; abscissa, time in seconds. Temperature 33-36 °C.