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Clinical and functional characterisation of rheumatic mitral regurgitation in children and adolescents including the brain natriuretic peptide

Published online by Cambridge University Press:  24 February 2010

Maria C. V. Ribeiro ,
Brivaldo Markman Filho ,
Cleusa C. L. Santos  and
Cristina P. Q. Mello
Maria C. V. Ribeiro*
Affiliation:
Department of Pediatric Cardiology, Instituto Materno Infantil Professor Fernando Figueira (IMIP), Recife-Pernambuco
Brivaldo Markman Filho
Affiliation:
Centro de Ciências da Saúde da UniversidadeFederal de Pernambuco, Department of Cardiology, Recife-Pernambuco, Brasil
Cleusa C. L. Santos
Affiliation:
Department of Pediatric Cardiology, Instituto Materno Infantil Professor Fernando Figueira (IMIP), Recife-Pernambuco
Cristina P. Q. Mello
Affiliation:
Department of Pediatric Cardiology, Instituto Materno Infantil Professor Fernando Figueira (IMIP), Recife-Pernambuco
*
Correspondence to: Maria C. V. Ribeiro, Rua Leonardo Bezerra Cavalcanti, número 300, Ap302, Jaqueira, Recife PE, Brasil, CEP52060030. Tel: 558121224770; Fax: 558121376500; E-mail: cristinavr@terra.com.br
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Abstract

Rheumatic fever is a public health problem of universal distribution, predominantly affecting individuals in developing countries. In individuals less than 20 years of age, pure mitral regurgitation is the most commonly found condition in chronic rheumatic valve disease. In the present study, rheumatic mitral regurgitation was assessed in children and adolescents, addressing its clinical (duration of the disease, symptoms, use of benzathine penicillin, and number of outbreaks of the acute phase of rheumatic fever), electrocardiographic (left atrium abnormality and/or left ventricle hypertrophy) and echocardiographic characteristics (left atrium and ventricle measurements, ejection fraction and pulmonary artery pressure), as well as plasma dose of N-terminal portion of the brain natriuretic peptide through electrochemiluminescence immunoassay. Fifty-three patients were studied. The patients had moderate (41.5%) or severe (58.5%) rheumatic mitral regurgitation; had not undergone surgery; were not in the acute phase of the disease; and were being treated at a paediatric cardiology reference hospital in Northeastern Brazil. Mean patient age was 10.6 years (minimum of 3 and maximum of 19 years). With the exception of the ejection fraction, the echocardiographic variables had a significant correlation to the natriuretic peptide, demonstrating that this hormone reflects the haemodynamic consequences of mitral regurgitation. It was concluded that cardiac remodelling that occurs in rheumatic mitral regurgitation in children and adolescents leads to the production of the brain natriuretic peptide, which could be used as a complementary diagnostic tool in the follow-up of such patients.

Keywords

Rheumatic fevermitral valve insufficiencyechocardiographyneurohormonal markers
Type
Original Articles
Information
Cardiology in the Young , Volume 20 , Issue 1 , February 2010 , pp. 66 - 72
Copyright
Copyright © Cambridge University Press 2010

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