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Prolactin-Secreting Adenomas - Surgical Results

Published online by Cambridge University Press:  18 September 2015

Giulio Maira ,
Carmelo Anile ,
Laura De Marinis  and
Antonino Barbarino
Giulio Maira*
Affiliation:
Institute of Neurosurgery, Catholic University, Rome, Italy
Carmelo Anile
Affiliation:
Institute of Neurosurgery, Catholic University, Rome, Italy
Laura De Marinis
Affiliation:
Institute of Endocrinology, Catholic University, Rome, Italy
Antonino Barbarino
Affiliation:
Institute of Endocrinology, Catholic University, Rome, Italy
*
Istituto di Neurochirurgia, Policlinico Gemelli, Largo Gemelli 8, 00168 Roma, Italia
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Abstract:

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The long-term follow-up of the transsphenoidal microsurgical treatment in 119 consecutively operated women with a PRL-secreting adenoma is presented. An apparent total removal of the tumor was achieved in 98 cases with an enclosed tumor (58 grade I and 40 grade II). In the remaining cases the removal was considered partial. The achievement of persistent normal PRL basal levels was verified in 61 patients (44 grade I and 17 grade II) who had an apparent total removal of the adenoma. In the 37 remaining patients who were thought at surgery to have had total removal we have distinguished two groups: 30 patients showed a “relapse” or “persistence” of PRL levels below 200 ng/ml without clinical and radiological signs of tumor regrowth, and 7 patients with a PRL level higher than 200 ng/ml who had evidence of PRL-secreting tumor recurrence.

Type
Special Supplement - Secreting Pituitary Adenomas
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 1 , February 1990 , pp. 67 - 70
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

REFERENCES

1.Barbarino, A, De Marinis, L, Menini, E, et al. Prolactin-secreting pituitary adenomas: prolactin dynamics before and after transsphenoidal surgery. Acta Endocrinol 1979; 91: 397–409.Google ScholarPubMed
2.Jaquet, P, Grisoli, M, Guibout, M, et al. Prolactin secreting tumors. Endocrine status before and after surgery in 33 women. J Clin Endocrinol Metab 1978; 46: 459–466.CrossRefGoogle ScholarPubMed
3.Hardy, J.Transsphenoidal microsurgery of prolactinomas: report on 355 cases. In: Tolis, Get al, eds. Prolactin and Prolactinomas. New York: Raven Press 1983; 431–440.Google Scholar
4.Maira, GRossi, GF, Anile, C, et al. Prolactinomas: surgical results in 96 cases. In: Auer, LM, Leb, G, Tscherne, G, Urdl, W, Walter, GF, eds. Prolactinomas. Berlin-New York: Walter de Gruyter 1985; 225–230.Google Scholar
5.Giovanelli, M, Gaini, S, Tomei, G, et al. Follow-up review of microprolactinomas operated in 48 female patients. Excerpta Med Int Congr Ser 1982; 584: 189–196.Google Scholar
6.Rodman, EF, Molitch, ME, Post, KD, et al. Long-term follow-up of transsphenoidal selective adenomectomy for prolactinomas. JAMA 1984; 252: 921–924.CrossRefGoogle Scholar
7.Schlechte, JA, Sherman, BM, Chapler, FK, et al. Long-term follow-up of women with surgical treated prolactin-secreting pituitary tumors. J Clin Endocrinol Metab 1986; 62: 1296–1301.CrossRefGoogle ScholarPubMed
8.Serri, O, Rasio, E, Beauregard, H, et al. Recurrence of hyperprolactinemia after selective transsphenoidal adenomectomy in women with prolactinoma. N Engl J Med 1983; 309: 280–283.CrossRefGoogle ScholarPubMed
9.Hardy, JVezina, JL.Transsphenoidal neurosurgery of intracranial neoplasm. In: Thompson, RA, Green, JR eds. Advances in Neurology. New York: Raven Press 1976; 261–264.Google ScholarPubMed
10.Barbarino, A, De Marinis, L, Anile, C, et al. Dopaminergic mechanisms regulating prolactin secretion in patients with prolactinsecreting pituitary adenoma. Long-term studies after selective transsphenoidal surgery. Metabolism 1982; 31: 1100–1104.Google ScholarPubMed
11.Barbarino, ADe Marinis, L, Menini, E, et al. Pre- and postoperative pituitary function tests in patients with prolactin-secreting pituitary adenoma. In: Camanni, F, Müller, EE eds. Pituitary Hyperfunction: Physiopathology and Clinical Aspects. New York: Raven Press 1984; 333–342.Google Scholar
12.De Marinis, L, Mancini, A, Maira, G, et al. Postoperative evaluation of dopaminergic tone in prolactinoma patients. II. Plasma thyrotropin response to metoclopramide. J Clin Endocrinol Metab 1984; 58: 405–409.CrossRefGoogle ScholarPubMed
13.Tucker, HStG, Grubb, SR, Wigand, JP, et al. Galactorrhea-amenorrhea syndrome: follow-up of forty-five patients after pituitary tumor removal. Ann Intern Med 1981; 94: 302–307.Google ScholarPubMed
14.Barbarino, A, De Marinis, L, Mancini, A, et al. Prolactin dynamics in patients with non-secreting tumors of the hypothalamic-pituitary region. Acta Endocrinol 1985; 110: 10–16.Google ScholarPubMed
15.Maira, G, Di Rocco, C, Anile, C, et al. Hyperprolactinemia as the first symptom of craniopharyngioma. Child’s Brain 19812; 9: 205–210.Google Scholar
16.Maira, G, Anile, C, Roselli, R, et al. Tableau anatomo-chirurgical et troubles endocriniens dans la pathologie diencéphalohypophysaire. Aggressologie 1986; 27: 217–219.Google Scholar