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Vitamin C status, serum cholesterol levels and bile composition in the pregnant guinea-pig

Published online by Cambridge University Press:  25 February 2008

S. A. Jenkins
S. A. Jenkins
Affiliation:
J. A. Pye Research Centre, Walnut Tree Manor, Haughley Green, Suffolk
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Abstract

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1. Pregnant guinea-pigs receiving a low dose of L-ascorbic acid (0.2 mg/100 g body-weight per d) developed a hypercholesterolaemia in the third trimester of pregnancy, whereas no change in serum cholesterol levels was observed in pregnant animals receiving a higher dose of the vitamin (2 mg/100 g body-weight per d).

2. Pregnancy in the group of guinea-pigs receiving the higher dose of L-ascorbic acid was associated with an increased biliary secretion of bile acids. No change was observed in the biliary secretion of bile acids in pregnant animals receiving the lower dose of L-ascorbic acid, but these animals secreted significantly more cholesterol.

3. Changes in the biliary secretion of cholesterol and bile acids in the pregnant guinea-pig according to L-ascorbic acid intake were reflected in the composition of the gall-bladder bile. Thus, the gall-bladder bile of guinea-pigs receiving the lower dose of L-ascorbic acid contained more cholesterol, while the gall-bladder bile of those animals receiving the higher dose of the vitamin had a higher content of bile acids.

4. The increased cholesterol content of the gall-bladder of pregnant guinea-pigs receiving the lower dose of L-ascorbic acid resulted in decreased bile acid:cholesterol and phospholipid: cholesterol values, conditions predisposing to cholelithiasis.

Type
Papers on direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 43 , Issue 1 , January 1980 , pp. 95 - 100
Copyright
Copyright © The Nutrition Society 1980

References

REFERENCES

Admirand, W. H. & Small, D. M. (1968). J. clin. Invest. 47, 1043.CrossRefGoogle Scholar
Boyd, E. M. & Fellows, M. D. (1936). Am. J. Physiol. 114, 635.CrossRefGoogle Scholar
Caldwell, F. J. Jr., Levitsky, K. & Rosenberg, B. (1965). Am. J. Physiol. 209, 473.CrossRefGoogle Scholar
Comess, L. J., Bennet, P. H. & Burch, T. (1967). New Engl. J. Med. 277, 894.CrossRefGoogle Scholar
Crump, C. (1931). Surgery Gynec. Obstet. 53, 447.Google Scholar
Fillios, L. C., Kaplan, R., Martin, R. S. & Stare, F. J. (1958). Am. J. Physiol. 193, 47.CrossRefGoogle Scholar
Friedman, G. D.. Kannel, W. B. & Dauber, T. R. (1966). J. chron. Dis. 19, 273.CrossRefGoogle Scholar
Ginter, E. (1973). Science, N. Y. 179, 702.CrossRefGoogle Scholar
Ginter, E., Bilisics, I. & Cervea, J. (1965). Physiologia bohemoslov 14, 466.Google Scholar
Ginter, E., Ondreička, R., Bobek, P. & Simko, V. (1969). J. Nutr. 99, 261.CrossRefGoogle Scholar
Green, J. C. (1966). Am. J. Obst. Gynec. 95, 387.CrossRefGoogle Scholar
Holzbach, R. T., Marsh, M. E. & Hallberg, M. C. (1971). Gastroenterology 60, 288.CrossRefGoogle Scholar
Isaksson, B. (1954). Acta Soc. Med. upsal. 59, 296.Google Scholar
Jenkins, S. A. (1977 a). Experientia 33, 1616.CrossRefGoogle Scholar
Jenkins, S. A. (1977 b). Biochem. Biophys. Res. Commun. 77, 1930.CrossRefGoogle Scholar
Jenkins, S. A. (1978). Br. J. Nutr. 40, 317.CrossRefGoogle Scholar
Large, A. M., Johnston, C. G., Katsuki, T. & Fachnie, H. L. (1960). Am. J. med. Sci. 293, 713.CrossRefGoogle Scholar
Li, J. R., Bale, L. K. & Subbiah, M. T. R. (1978). Steroids 31, 2288.CrossRefGoogle Scholar
McSherry, C. K., Deitrick, J. E., Mary, P. S., Niemann, W., Morissey, K. P., Palmer, R. H. & Glenn, F. (1977). Surgery Gynec. Obstet. 144, 727.Google Scholar
McSherry, C. K., Javitt, N. B., Carvalho, J. M. & Glenn, F. (1971). Ann. Surg. 173, 569.CrossRefGoogle Scholar
Martin, M. P., Bridgforth, E., McGinty, W. J. & Darby, W. J. (1957). J. Nutr. 62, 201.CrossRefGoogle Scholar
Osuga, T. & Portman, O. (1971). Proc. Soc. exp. Biol. Med. 136, 722.CrossRefGoogle Scholar
Paul, P. K. & Duttagupta, P. N. (1974). Fert. Steril. 25, 68.CrossRefGoogle Scholar
Potter, M. G. (1936). J. Am. med. Ass. 106, 1070.CrossRefGoogle Scholar
Riegal, C., Ravdin, I. S. & Johnston, C. G. (1936). Surgery Gynec. Obstet. 62, 933.Google Scholar
Robertson, H. E. (1944). Int. Abstr. Surg. Gynec. Obstet. 78, 193.Google Scholar
Röschlau, P., Bernt, E. & Gruber, W. (1976). Z. Klin. Chem. U. Klin. Biochem. 12, 403.Google Scholar
Svanborg, A. & Vikrot, O. (1965). Acta med. Scand. 178, 615.CrossRefGoogle Scholar
Talalay, P. (1960). Meth. biochem. Analysis 8, 119.CrossRefGoogle Scholar
Wilson, C. W. M. & Loh, H. S. (1973). Lancet ii, 859.CrossRefGoogle Scholar
Wolfe, R. C., Tempte, L. & Meyer, R. K. (1967). Proc. Soc. exp. Biol. Med. 125, 1230.CrossRefGoogle Scholar
Zilversmit, D. B., Hughes, L. B. & Remmington, M. J. (1972). J. Lipid Res. 13, 750.CrossRefGoogle Scholar