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The protein-sparing effect of carbohydrate

2.* The role of insulin

Published online by Cambridge University Press:  09 March 2007

M. F. Fuller ,
T. E. C. Weekes ,
A. Cadenhead  and
J. B. Bruce
M. F. Fuller
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
A. Cadenhead
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
J. B. Bruce
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

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1. In five experiments with growing female pigs of 38–63 kg, insulin (2 mU/kg per min) and glucose (9–17 mg/kg per min) were infused continuously for 3–7 d. In three further experiments, glucose (9 mg/kg per min) was infused alone for 5 d.

2. In response to the combined infusion, plasma insulin increased 2-7-fold, plasma glucose decreased, on average, by 50% and plasma urea concentration was reduced by 40%. Urinary excretion of urea and nitrogen decreased after the first day of infusion to values averaging 70% of control levels.

3. The infusion of glucose alone provoked only a small increase in plasma insulin. The reduction of urinary urea and of N excretion were approximately 25% of those observed with the combined infusions.

Type
Research Article
Information
British Journal of Nutrition , Volume 38 , Issue 3 , November 1977 , pp. 489 - 496
Copyright
Copyright © The Nutrition Society 1977

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