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Effect of dietary protein level and thyroxine on vitamin A depletion from liver in chicks

Published online by Cambridge University Press:  09 March 2007

I. Nir  and
I. Ascarelli
I. Nir
Affiliation:
Department of Animal Nutrition and Agricultural Biochemistry, Hebrew University, Rehovot, Israel
I. Ascarelli
Affiliation:
Department of Animal Nutrition and Agricultural Biochemistry, Hebrew University, Rehovot, Israel
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Abstract

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1. The effect of dietary protein level and supplementation with thyroxine and thiouracil on depletion of liver stores of vitamin A, on the percentage of liver vitamin A in the alcohol form and on the plasma level of vitamin A and protein has been studied in chicks. In an experiment with cockerels the relation was investigated between the vitamin A level of plasma and the electrophoretic pattern of its proteins.

2. Liver vitamin A depletion was considerably reduced by lowering the dietary protein level.

3. Protein malnutrition lowered the percentage of vitamin A found in the liver in the alcohol form.

4. Depletion of vitamin A from the liver was related to the percentage of vitamin A in the alcohol form.

5. Thyroxine increased both vitamin A depletion from the liver and the percentage of vitamin A in the alcohol form, whereas thiouracil had the opposite effect.

6. Plasma vitamin A, and plasma protein contents were significantly lowered in cockerels receiving a 5% protein diet. The drop in plasma protein level was essentially caused by a reduction of the albumin fraction. No significant change in the levels of globulins was observed even after a 4-week period of protein malnutrition.

7. When the dietary protein level was restored to normal both the albumin and vitamin A levels in plasma increased.

Type
Research Article
Information
British Journal of Nutrition , Volume 20 , Issue 1 , February 1966 , pp. 41 - 53
Copyright
Copyright © The Nutrition Society 1966

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