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The biochemical basis of antioxidant therapy in critical illness

Published online by Cambridge University Press:  07 March 2007

Simon Eaton
Simon Eaton*
Affiliation:
Unit of Paediatric Surgery and Biochemistry, Endocrinology and Metabolism Unit, Institute of Child Health (University College London), 30 Guilford Street, London WC1N 1EH, UK
*
Corresponding author: Simon Eaton, fax +44 20 7404 6181, email s.eaton@ich.ucl.ac.uk
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Abstract

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During critical illness free radical production may increase as a result of, for example, sepsis or tissue trauma. In addition, because of a potential for increased losses, and the possibility of inadequate nutrition, the antioxidant defences of the body may become compromised. Thus, the delicate balance between free radicals and antioxidants may be disturbed. Various nutritional and pharmacological strategies to enhance antioxidant defences have been proposed, which aim either to maintain or enhance endogenous antioxidant stores or to provide alternative antioxidant agents. Trace elements and amino acids are particularly important, and their synergistic role in the maintenance of the body's antioxidant defence network will be discussed.

Keywords

Critical illnessFree radical productionAntioxidant therapySepsis
Type
BAPEN Symposium 4 on ‘Glutamine and antioxidants in critical care’
Information
Proceedings of the Nutrition Society , Volume 65 , Issue 3 , August 2006 , pp. 242 - 249
Copyright
Copyright © The Nutrition Society 2006

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