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Illuminating nano-bio interactions: A spectroscopic perspective

Published online by Cambridge University Press:  13 November 2014

Ramakrishna Podila ,
Jared M. Brown ,
Anne Kahru  and
Apparao M. Rao
Ramakrishna Podila
Affiliation:
Clemson Nanomaterials Center, Clemson University, USA;rpodila@g.clemson.edu
Jared M. Brown
Affiliation:
University of Colorado Anschutz Medical Campus, USA;jared.brown@ucdenver.edu
Anne Kahru
Affiliation:
National Institute of Chemical Physics and Biophysics, Estonia;anne.kahru@kbfi.ee
Apparao M. Rao
Affiliation:
Department of Physics and Astronomy, Clemson University, USA;arao@clemson.edu
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Abstract

Engineered nanomaterials (ENMs) strongly interact with biomolecules and cells due to their similar size scales. Consequently, ENMs are beginning to emerge as new medical diagnostic tools, probes in cell biology, and delivery vehicles, compelling us to understand the interactions at the nano-bio interface. Optical spectroscopic tools are excellent probes to characterize ENMs and investigate their interactions with complex biological systems, including biomolecules, cells, and even whole animals alike. Here, we discuss the role of many optical spectroscopic techniques such as fluorescence, Raman, surface plasmon, and infrared spectroscopy in elucidating nano-bio interactions. While these spectroscopic tools have the ability to provide valuable information on ENM distribution in biosystems, ENM interaction with proteins, and the mechanisms by which ENMs elicit an adverse physiological response, there are many challenges that remain to be addressed to improve their scope, resolution, and throughput.

Keywords

Nanoscaleoxidesnanostructuresoptical propertiesluminescenceRaman spectroscopy
Type
Research Article
Information
MRS Bulletin , Volume 39 , Issue 11: Biological Interactions of Oxide Nanoparticles: The Good and The Evil , November 2014 , pp. 990 - 995
Copyright
Copyright © Materials Research Society 2014 

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