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Emerging Treatments: Replacement Therapy with Choline or Lecithin in Neurological Diseases

Published online by Cambridge University Press:  18 September 2015

A. Barbeau
A. Barbeau*
Affiliation:
Clinical Research Institute of Montreal and the University of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7
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This review evaluates the theoretical background and experimental data behind a new development: the replacement therapy of deficient central cholinergic systems with the dietary precursors choline or lecithin. Cholinergic deficiency states are possibly present in five neurological entities: Huntington's chorea, Tardive Dyskinesia, Gilles de la Tourette's disease, Friedreich's ataxia and presenile dementia. Preliminary data from various laboratories, including our own, in each of these disorders indicate that some clinical improvement can occasionally be seen, and that this approach deserves further investigation.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 1 , February 1978 , pp. 157 - 160
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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