Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-23T08:37:26.469Z Has data issue: false hasContentIssue false
  • English
  • Français

Catch-up growth in children with late-diagnosed coeliac disease

Published online by Cambridge University Press:  08 March 2007

A. K. Patwari ,
Gaurav Kapur ,
L. Satyanarayana ,
V. K. Anand ,
Amit Jain ,
Ashutosh Gangil  and
Bharat Balani
A. K. Patwari*
Affiliation:
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Lady Hardinge Medical College & Associated Kalawati Saran Children's Hospital, New Delhi, India
Gaurav Kapur
Affiliation:
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Lady Hardinge Medical College & Associated Kalawati Saran Children's Hospital, New Delhi, India
L. Satyanarayana
Affiliation:
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Lady Hardinge Medical College & Associated Kalawati Saran Children's Hospital, New Delhi, India Division of Epidemiology and Biostatistics, Institute of Cytology and Preventive Oncology (ICMR), NOIDA, (UP), India
V. K. Anand
Affiliation:
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Lady Hardinge Medical College & Associated Kalawati Saran Children's Hospital, New Delhi, India
Amit Jain
Affiliation:
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Lady Hardinge Medical College & Associated Kalawati Saran Children's Hospital, New Delhi, India
Ashutosh Gangil
Affiliation:
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Lady Hardinge Medical College & Associated Kalawati Saran Children's Hospital, New Delhi, India
Bharat Balani
Affiliation:
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Lady Hardinge Medical College & Associated Kalawati Saran Children's Hospital, New Delhi, India
*
*Corresponding author: Professor A. K. Patwari, email gudu@ndf.vsnl.net.in, akpatwari@hotmail.com
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Anthropometric parameters and catch-up growth were prospectively evaluated in fifty late-diagnosed children with coeliac disease aged 2·25–10 years after 1–4 years of adhering to a strict gluten-free diet (GFD). The anthropometric parameters were expressed as Z scores relative to National Centre for Health Statistics standards using Epi Info 2000 (weight-for-height Z score (WHZ) and height-for-age Z score (HAZ)). Catch-up growth was evaluated by repeated measures. ANOVA, overall significance by an F test and pair-wise comparisons for estimated marginal means using the least significant difference. At the time of enrolment, no significant difference was observed in WHZ and HAZ between children diagnosed before (group 1) or after (group 2) 4 years of age. On follow-up, HAZ was significantly higher in group 1 after the first and third years of the GFD (P=0·04 and 0·02, respectively), with a non-significant increase after completing 4 years of the GFD (P=0·22). Feeding the GFD resulted in an overall significant (F=3·99, P=0·011) increase in HAZ up to 4 years of follow-up. However, the catch-up in height was incomplete, with stunting in sixteen (55·4 %) of twenty-nine children after 3 years and in seven (46·6 %) of fifteen children after 4 years on the GFD. Pair-wise comparisons demonstrated a linear catch-up growth during the initial follow-up on GFD. Treatment with the GFD did not result in an overall significant increase in WHZ up to 4 years of follow-up (F=1·01, P=0·42). Our results suggest that, in children with late-diagnosed coeliac disease, treatment with a GFD leads to a normalisation of body mass and a significant but incomplete recovery in HAZ during 4 years of follow-up.

Keywords

Catch-up growthGluten-free dietGluten enteropathyCoeliac disease
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 3 , September 2005 , pp. 437 - 442
Copyright
Copyright © The Nutrition Society 2005

References

Barr, DGD, Shomerling, DH & Prader, A (1972) Catch-up growth in malnutrition, studied in celiac disease after institution of gluten free diet. Pediatr Res 6, 521–527.Google Scholar
Bosio, L, Barera, G, Mistura, L, Sassi, G & Bianchi, C (1990) Growth acceleration and final height after treatment for delayed diagnosis of celiac disease. J Pediatr Gastroenterol Nutr 11, 324–329.Google ScholarPubMed
Cartson, BA & Wardlaw, TM (1990) A Global, Regional and Country Assessment of Child Malnutrition. UNICEF Staff Working Paper no. 7 New York: UN Children's Fund.Google Scholar
Cataldo, F, La Tena, D, Mirto, G, La Monaca, P & Albeggiani, A (1987) Compartmento dello stato auxologico edi almini indici nutrizonali in ungruppo di bambini celiaci. Minerva Pediatr 39, 187–190.Google Scholar
Damen, GM, Boersma, B, Wit, JM & Heymans, HS (1994) Catch up growth in 60 children with celiac disease. J Pediatr Gastroenterol Nutr 19, 394–400.Google Scholar
Federico, G, Favilli, T, Cinquanta, L, Ughi, C & Saggese, G (1997) Effect of celiac disease and gluten free diet on growth hormone binding protein, insulin-like growth factor-1, and insulin-like growth factor-binding protein. Horm Res 48, 108–114.Google Scholar
Gerolamo, G, Vignolo, M, Nuselli, A & Garzia, P (1999) Linear growth and skeletal maturation in subjects with treated celiac disease. J Pediatr Gastroenterol Nutr 29, 339–342.Google Scholar
Gorstein, J, Sullivan, K, Yip, R, de Onis, M, Trowbridge, F, Fajans, P & Clugston, G (1994) Issues in the assessment of nutritional status using anthropometry. Bull World Health Organ 72, 273–283.Google Scholar
Greco, L, Tipo, V, Donato Di, F & Mayer, M (1994) Pulsatile growth during catch up growth in childhood celiac disease. Acta Pediatr 83, 724–729.CrossRefGoogle Scholar
Grikk, A, Prece, MA, Candy, DCA & Tanner, JM (1980) Short stature as primary manifestation of celiac disease. Lancet ii, 1097–1099.Google Scholar
Hamill, PVV, Drizd, TA, Johnson, CL, Reed, RB, Roche, AF & Moore, WM (1979) Physical growth: National Center for Health Statistics. Am J Clin Nutr 32, 607–629.CrossRefGoogle ScholarPubMed
Hernandez, M, Argente, J, Navarro, A, Caballo, N, Barrios, V, Hervas, F & Polanco, (1992) Growth in malnutrition related to gastrointestinal diseases: celiac disease. Horm Res 38 Suppl 179–84Google Scholar
Kappu Swamy, B (1976) Manual of Socio-economic Status Scale (Urban) Delhi: Manasayan.Google Scholar
Kumar, M, Yaccha, SK & Naik, SR (1993) Celiac disease in children. Indian J Gastroenterol 12, A15Google Scholar
Luca De, F, Astori, M, Panduelo, E, Sferlazzas, C, Arrigo, T, Sindeni, A & Magazzu, G (1988) Effect of gluten free diet on catch up growth and height prognosis in celiac children with growth retardation recognized after the age of 5 years. Eur J Pediatr 147, 188–191.CrossRefGoogle Scholar
Luciano, A, Bolognani, M, Di Falco, A, Trabucchi, C, Bonetti, P & Castellar, A (2002) Catch up growth and final height in celiac disease. Pediatr Med Chir 24, 9–12.Google ScholarPubMed
Maki, M, Kallonen, K, Lahdeaho, ML & Visakorpi, JK (1988) Changing pattern of childhood celiac disease in Finland. Acta Paediatr Scand 77, 408–412.Google Scholar
Patwari, AK, Anand, VK, Kapur, G & Narayan, S (2003) Clinical and nutritional profile of children with celiac disease. Indian Pediatr 40, 337–342.Google Scholar
Poddar, U (1999) Celiac disease: clinical features and diagnostic criteria. Indian J Pediatr 66, S21–S25.Google ScholarPubMed
Prader, A, Tanner, JM & Von Harnach, GA (1963) Catch up growth following illness or starvation. An example of developmental canalisation in man. J Pediatr 62, 646–659.CrossRefGoogle ScholarPubMed
Rea, F, Polito, C, Marotta, A, Di Toro, A, Iovene, A, Collini, R, Rea, L & Sessa, G (1996) Restoration of body composition in celiac children after one year of gluten-free diet. J Pediatr Gastroenterol Nutr 23, 408–412.Google Scholar
Rosenback, Y, Dinari, G, Zahavi, I & Nitzan, M (1986) Short stature as the major manifestation of celiac disease in older children. Clin Pediatr 25, 13–16.CrossRefGoogle Scholar
Tanner, JM (1981) Catch up growth in man. Br Med Bull 37, 233–238.CrossRefGoogle ScholarPubMed
Walker Smith, JA (1985) Celiac disease. In Diseases of Small Intestine in Children, 3rd ed. 88–143 [Walker Smith, JA, editor] London: utterworth-Heinemann.Google Scholar
Working Group of the European Society of Pediatric Gastroenterology and Nutrition (1990) Revised criteria for diagnosis of celiac disease. Arch Dis Child 65, 909–911.Google Scholar
World Health Organization (1995) Physical Status: The Use and Interpretation of Anthropometry. Report of a WHO Expert Committee. WHO Technical Report Series no. 854 Geneva: WHO.Google Scholar
World Health Organization Working Group (1986) Use and interpretation of anthropometric indicators of nutritional status. Bull World Health Organ 64, 929–941.Google Scholar
Yaccha, SK, Misra, S, Malik, AK, Nagi, B & Mehta, S (1993) Spectrum of malabsorption syndrome in North Indian children. Indian J Gastroenterol 12, 120–125.Google Scholar