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Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice

Published online by Cambridge University Press:  08 March 2007

Daichi Oikawa ,
Tomonori Nakanishi ,
Yoshi-nori Nakamura ,
Takaya Yamamoto ,
Atsuko Yamaguchi ,
Nobuya Shiba ,
Hisao Iwamoto ,
Tetsuya Tachibana  and
Mitsuhiro Furuse
Daichi Oikawa
Affiliation:
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan
Tomonori Nakanishi
Affiliation:
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan
Yoshi-nori Nakamura
Affiliation:
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan
Takaya Yamamoto
Affiliation:
Rinoru Oil Mills Co. Ltd, Nagoya 455-0028, Japan
Atsuko Yamaguchi
Affiliation:
Rinoru Oil Mills Co. Ltd, Nagoya 455-0028, Japan
Nobuya Shiba
Affiliation:
National Agricultural Research Center for Kyusyu Okinawa Region, Nishigoshi 861-1192, Japan
Hisao Iwamoto
Affiliation:
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan
Tetsuya Tachibana
Affiliation:
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan
Mitsuhiro Furuse*
Affiliation:
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan
*
*Corresponding author: Dr Mitsuhiro Furuse, fax +81 92 642 2953, email furuse@brs.kyushu-u.ac.jp
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Abstract

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The effects of conjugated linoleic acid (CLA), γ-linolenic acid (GLA), linoleic acid (LA), and their combinations, on skin composition in mice were investigated. Mice (8 weeks old) were orally administered with either LA, GLA, CLA, LA + GLA, LA + CLA, or CLA + GLA for 4 weeks. Then, the skin was analysed for triacylglycerol content, fatty acid composition and collagen content. Additionally, thicknesses of the dermis layer and subcutaneous tissue layer, and the size and number of adipocytes were measured histologically. The skin fatty acid composition was modified depending upon the fatty acid composition of supplemented oils. In each oil-alone group, skin triacylglycerol content was the highest in LA, followed by GLA and CLA treatments. Combinations with CLA had a similar triacylglycerol content compared with the CLA-alone group. No significant changes in collagen content were observed among any treatments. The effects on subcutaneous thickness were similar to the results obtained in the triacylglycerol contents, where groups supplemented with CLA alone or other fatty acids had significantly thinner subcutaneous tissue compared with the LA-alone group. However, no significant difference was detected in the thickness of the dermis layers. The number of adipocytes was highest in the LA + GLA group and tended to be reduced by CLA with or without the other fatty acids. These results suggest that CLA alone or in combination with other fatty acids strongly modifies skin composition in mice.

Keywords

Conjugated linoleic acidγ-Linolenic acidSubcutaneous tissue
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 2 , August 2005 , pp. 275 - 281
Copyright
Copyright © The Nutrition Society 2005

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