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The effect of chronic ethanol administration on lipogenesis in liver and adipose tissue in the rat

Published online by Cambridge University Press:  24 July 2007

Carmen Cascales ,
Manuel Benito ,
María Cascales ,
Trinidad Caldés  and
Angel Santos-Ruiz
Carmen Cascales
Affiliation:
Departamento de Bioquímica, Facultad de Farmacia, Centro Coordinado del CSIC, Universidad Complutense, Madrid-3, Spain
Manuel Benito
Affiliation:
Departamento de Bioquímica, Facultad de Farmacia, Centro Coordinado del CSIC, Universidad Complutense, Madrid-3, Spain
María Cascales
Affiliation:
Departamento de Bioquímica, Facultad de Farmacia, Centro Coordinado del CSIC, Universidad Complutense, Madrid-3, Spain
Trinidad Caldés
Affiliation:
Departamento de Bioquímica, Facultad de Farmacia, Centro Coordinado del CSIC, Universidad Complutense, Madrid-3, Spain
Angel Santos-Ruiz
Affiliation:
Departamento de Bioquímica, Facultad de Farmacia, Centro Coordinado del CSIC, Universidad Complutense, Madrid-3, Spain
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Abstract

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1. Rates of lipogenesis de novo have been studied in liver and epididymal fat pads of male rats chronically treated with ethanol. A solution of ethanol (150 ml/l) was administered as the only drinking fluid for 3 months with a standard solid diet; both food and drink were available ad lib.

2. Lipogenesis in vivo was measured by the incorporation of tritiated water into lipid fractions: non-saponifiable lipid and fatty acids. Non-saponifiable lipid, both in liver and in adipose tissue, was unaffected by ethanol treatment. However, fatty acid synthesis de novo was significantly enhanced in both liver and adipose tissue, by 150 and 300% respectively.

3. Plasma triacylglycerol and non-esterified fatty acid levels were unchanged and plasma glucose concentration slightly increased by ethanol administration.

4. The rate of lipogenesis increased when insulin: glucagon increased twofold due to the effect of ethanol.

Type
Research Article
Information
British Journal of Nutrition , Volume 50 , Issue 3 , November 1983 , pp. 549 - 553
Copyright
Copyright © The Nutrition Society 1983

References

Bergmeyer, H. U. (1974). In Methoden der Enzymatische Analyse, pp. 1241–1246 [Bergmeyer, H. U., editor]. Weinheim: Verlag Chemie.Google Scholar
Brunengraber, H., Boutry, M., Lowenstein, L. & Lowenstein, J. M. (1974). In Alcohol and Aldehyde Metabolizing Systems, pp. 329–337 [Thurman, R. G.Yonetani, T.Williamson, J. R. and Chance, B., editors]. New York and London: Academic Press.Google Scholar
Cascales, C., Santos-Ruiz, M. R., Cascales, M. & Santos-Ruiz, A. (1981). Ciência Biologica (Portugal) 6, 219–222.Google Scholar
Eggstein, M. & Kuhlmann, E. (1974). In Methoden der Enzymatische Analyse, pp. 1271–1278 [Bergmeyer, H. U., editor]. Weinheim: Verlag Chemie.Google Scholar
Fellenius, E., Nisbeth, U., Pilström, L. & Kiessling, K. H. (1973). British Journal of Nutrition 29, 307–316.CrossRefGoogle Scholar
Guynn, R. W., Veloso, D., Harris, R. L., Lawson, J. W. R. & Veech, R. L. (1973). Biochemical Journal 136, 639–647.CrossRefGoogle Scholar
Hales, C. N. & Randle, P. J. (1963). Biochemical Journal 88, 137–146.CrossRefGoogle Scholar
Hanson, R. W. & Ballard, F. J. (1967). Biochemical Journal 105, 529–536.CrossRefGoogle Scholar
Hill, R., Linazasoro, J. M., Chevalier, F. & Chaicoff, I. L. (1958). Journal of Biological Chemistry 233, 305–310.CrossRefGoogle Scholar
Itaya, K. & Ui, M. (1965). Journal of Lipid Research 6, 16–20.CrossRefGoogle Scholar
Lieber, C. S. (1967). In Biochemical Factors of Alcoholism, pp. 167–183 [Maickel, R. P., editor]. Oxford: Pergamon Press.Google Scholar
Lieber, C. S. (1975). Annals of the New York Academy of Sciences 252, 24–50.CrossRefGoogle Scholar
Lieber, C. S. & De Carli, L. M. (1970). American Journal of Clinical Nutrition 23, 474–479.CrossRefGoogle Scholar
Lieber, C. S. & Rubin, E. (1969). New England Journal of Medicine 280, 705–708.CrossRefGoogle Scholar
Lieber, C. S. & Schmidt, R. (1961). Journal of Clinical Investigation 44, 1009–1021.CrossRefGoogle Scholar
Lieber, C. S., Spritz, N. & De Carli, L. M. (1969). Journal of Lipid Research 10, 283–287.CrossRefGoogle Scholar
Lorenzo, M., Caldés, T., Benito, M. & Medina, J. M. (1981). Biochemical Journal 198, 425–428.CrossRefGoogle Scholar
Lowenstein, J. M., Brunengraber, H. & Wadke, M. (1975). Methods in Enzymology 35, 279–287.CrossRefGoogle Scholar
Luyckx, A. S. (1972). In Glucagon, pp. 285–298 [Lefevre, R. J. and Unger, R. H., editors]. Oxford: Pergamon Press.Google ScholarPubMed
Matthes, K. J., Abraham, S. & Chaicoff, I. L. (1960). Journal of Biological Chemistry 235, 2560–2568.CrossRefGoogle Scholar
Sameshima, Y. (1979). Acta Medica University Kagoshima 21, 45–63.Google Scholar
Savolainen, M. J., Hiltunen, J. K. & Hassinen, I. E. (1977). Biochemical Journal 164, 169–177.CrossRefGoogle Scholar
Stansbie, D., Brownsey, R. W., Crettaz, M. & Denton, R. M. (1976). Biochemical Journal 160, 413–416.CrossRefGoogle Scholar
Windmueller, H. E. & Spaeth, A. E. (1966). Journal of Biological Chemistry 241, 2891–2899.CrossRefGoogle Scholar