Hostname: page-component-7c8c6479df-24hb2 Total loading time: 0 Render date: 2024-03-29T04:15:50.777Z Has data issue: false hasContentIssue false

A chromosome-wide QTL study on BTA29 affecting temperament traits in German Angus beef cattle and mapping of DRD4

Published online by Cambridge University Press:  21 September 2010

K. Glenske
Affiliation:
Department of Animal Breeding and Genetics, Justus Liebig University of Giessen, Ludwigstr. 21b, 35390 Giessen, Germany
E.-M. Prinzenberg
Affiliation:
Department of Animal Breeding and Genetics, Justus Liebig University of Giessen, Ludwigstr. 21b, 35390 Giessen, Germany
H. Brandt
Affiliation:
Department of Animal Breeding and Genetics, Justus Liebig University of Giessen, Ludwigstr. 21b, 35390 Giessen, Germany
M. Gauly
Affiliation:
Department of Animal Science, Georg August University of Göttingen, Albrecht-Thaer-Weg 3, 37075 Göttingen, Germany
G. Erhardt*
Affiliation:
Department of Animal Breeding and Genetics, Justus Liebig University of Giessen, Ludwigstr. 21b, 35390 Giessen, Germany
Get access

Abstract

The behaviour of beef cattle is important for the safety and welfare of stockmen and animals. Ten microsatellites spanning BTA29 and, in addition, the candidate gene, dopamine receptor D4 gene, were analysed in 545 German Angus calves of six sires and included in a quantitative trait locus (QTL) study on the basis of three different behaviour tests. A putative QTL for the score while entering the scale (ScE) was detected at BMS764. The DRD4 fragment was mapped in the distal region of BTA29 15.3 cM distal of ILSTS081. The results clearly indicate that BTA29 with a putative QTL in the proximal part and the candidate gene, DRD4, in the distal part plays an important role in the regulation of temperament. During the study one of the sires was detected to be a blood chimera.

Type
Full Paper
Copyright
Copyright © The Animal Consortium 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Boissy, A, Bouissou, MF 1988. Effects of early handling on heifer’s subsequent reactivity to humans and to unfamiliar situations. Applied Animal Behaviour Science 20, 259273.CrossRefGoogle Scholar
Burrow, HM 1997. Measurement of temperament and their relationship with performance traits of beef cattle. Animal Breeding Abstracts, 478495.Google Scholar
Ducos, A, Revay, T, Kovacs, A, Hidas, A, Pinton, A, Bonnet-Garnier, A, Molteni, L, Slota, E, Switonski, M, Arruga, MV, van Haeringen, WA, Nicolae, I, Chaves, R, Guedes-Pinto, H, Andersson, M, Iannuzzi, L 2008. Cytogenetic screening of livestock populations in Europe: an overview. Cytogenetic and Genome Research 120, 2641.CrossRefGoogle ScholarPubMed
Fidler, AE, van Oers, K, Drent, PJ, Kuhn, S, Mueller, JC, Kempenaers, B 2007. Drd4 gene polymorphisms are associated with personality variation in a passerine bird. Proceedings of the Royal Society of London. Series B: Biological Sciences 274, 16851691.Google Scholar
Gauly, M, Mathiak, H, Hoffmann, K, Kraus, M, Erhardt, G 2001. Estimating genetic variability in temperamental traits in German Angus and German Simmental cattle. Applied Animal Behaviour Science 74, 109119.CrossRefGoogle Scholar
Goldgar, DE, Green, P, Parry, DM, Mulvihill, JJ 1989. Multipoint linkage analysis in neurofibromatosis type I: an international collaboration. American Journal of Human Genetics 44, 612.Google ScholarPubMed
Green, P 1992. Construction and comparison of chromosome 21 radiation hybrid and linkage maps using CRI-MAP. Cytogenetics and Cell Genetics 59, 122124.CrossRefGoogle ScholarPubMed
Gutiérrez-Gil, B, Ball, N, Burton, D, Haskell, M, Williams, JL, Wiener, P 2008. Identification of quantitative trait loci affecting cattle temperament. The Journal of Heredity 99, 629638.CrossRefGoogle ScholarPubMed
Haegeman, A, Williams, JL, Law, A, Van Zeveren, A, Peelman, LJ 2003. Mapping and SNP analysis of bovine candidate genes for meat and carcass quality. Animal Genetics 34, 349353.CrossRefGoogle ScholarPubMed
Hearnshaw, H, Morris, CA 1984. Genetic and environmental effects on a temperament score in beef cattle. Australian Journal of Agricultural Research 35, 723733.CrossRefGoogle Scholar
Hiendleder, S, Thomsen, H, Reinsch, N, Bennewitz, J, Leyhe-Horn, B, Looft, C, Xu, N, Medjugorac, I, Russ, I, Kuhn, C, Brockmann, GA, Blumel, J, Brenig, B, Reinhardt, F, Reents, R, Averdunk, G, Schwerin, M, Forster, M, Kalm, E, Erhardt, G 2003. Mapping of QTL for body conformation and behavior in cattle. The Journal of Heredity 94, 496506.CrossRefGoogle ScholarPubMed
Iannuzzi, A, Di Meo, GP, Caputi Jambrenghi, A, Vonghia, G, Iannuzzi, L, Rangel-Figueiredo, T 2008. Frequency and distribution of rob(1;29) in eight Portuguese cattle breeds. Cytogenetic and Genome Research 120, 147149.CrossRefGoogle ScholarPubMed
Itoh, T, Watanabe, T, Ihara, N, Mariani, P, Beattie, CW, Sugimoto, Y, Takasuga, A 2005. A comprehensive radiation hybrid map of the bovine genome comprising 5593 loci. Genomics 85, 413424.CrossRefGoogle ScholarPubMed
Keltikangas-Jarvinen, L, Elovainio, M, Kivimaki, M, Lichtermann, D, Ekelund, J, Peltonen, L 2003. Association between the type 4 dopamine receptor gene polymorphism and novelty seeking. Psychosomatic Medicine 65, 471476.CrossRefGoogle ScholarPubMed
Larkin, DM, Everts-van der Wind, A, Rebeiz, M, Schweitzer, PA, Bachman, S, Green, C, Wright, CL, Campos, EJ, Benson, LD, Edwards, J, Liu, L, Osoegawa, K, Womack, JE, de Jong, PJ, Lewin, HA 2003. A cattle–human comparative map built with cattle BAC-ends and human genome sequence. Genome Research 13, 19661972.CrossRefGoogle ScholarPubMed
Momozawa, Y, Takeuchi, Y, Kusunose, R, Kikusui, T, Mori, Y 2005. Association between equine temperament and polymorphisms in dopamine D4 receptor gene. Mammalian Genome 16, 538544.CrossRefGoogle ScholarPubMed
Morris, CA, Pitchford, WS, Cullen, NG, Esmailizadeh, AK, Hickey, SM, Hyndman, D, Dodds, KG, Afolayan, RA, Crawford, AM, Bottema, CD 2009. Quantitative trait loci for live animal and carcass composition traits in Jersey and Limousin back-cross cattle finished on pasture or feedlot. Animal Genetics 40, 648654.CrossRefGoogle ScholarPubMed
Niimi, Y, Inoue-Murayama, M, Murayama, Y, Ito, S, Iwasaki, T 1999. Allelic variation of the D4 dopamine receptor polymorphic region in two dog breeds, Golden retriever and Shiba. Journal of Veterinary Medical Sciences 61, 12811286.CrossRefGoogle ScholarPubMed
Peretti, V, Ciotola, F, Albarella, S, Paciello, O, Dario, C, Barbieri, V, Iannuzzi, L 2008. XX/XY chimerism in cattle: clinical and cytogenetic studies. Sexual Development 2, 2430.CrossRefGoogle ScholarPubMed
Rubinstein, M, Phillips, TJ, Bunzow, JR, Falzone, TL, Dziewczapolski, G, Zhang, G, Fang, Y, Larson, JL, McDougall, JA, Chester, JA, Saez, C, Pugsley, TA, Gershanik, O, Low, MJ, Grandy, DK 1997. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 90, 9911001.CrossRefGoogle ScholarPubMed
Schmutz, SM, Stookey, JM, Winkelman-Sim, DC, Waltz, CS, Plante, Y, Buchanan, FC 2001. A QTL study of cattle behavioral traits in embryo transfer families. The Journal of Heredity 92, 290292.CrossRefGoogle ScholarPubMed
Seaton, G, Haley, CS, Knott, SA, Kearsey, M, Visscher, PM 2002. QTL Express: mapping quantitative trait loci in simple and complex pedigrees. Bioinformatics (Oxford, England) 18, 339340.Google ScholarPubMed
Tulloh, NM 1961. Behaviour of cattle in yards. I. Weighing, order and behaviour before entering scales. Animal Behaviour 9, 2530.CrossRefGoogle Scholar
Vozdova, M, Kubickova, S, Cernohorska, H, Rubes, J 2008. Detection of translocation rob(1;29) in bull sperm using a specific DNA probe. Cytogenetic and Genome Research 120, 102105.CrossRefGoogle ScholarPubMed