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Micropatterned Flexible and Conformable Biofunctional Devices Using Silk Proteins

Published online by Cambridge University Press:  24 May 2016

Ramendra K. Pal ,
Ahmed A Farghaly ,
Maryanne M. Collinson ,
Subhas C. Kundu  and
Vamsi K. Yadavalli
Ramendra K. Pal
Affiliation:
Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia, USA.
Ahmed A Farghaly
Affiliation:
Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.
Maryanne M. Collinson
Affiliation:
Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.
Subhas C. Kundu
Affiliation:
Department of Biotechnology, Indian Institute of Technology, Kharagpur, West Bengal, India.
Vamsi K. Yadavalli*
Affiliation:
Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia, USA.
*
*(Email: vyadavalli@vcu.edu)
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Abstract

Intrinsically conductive polymers have received increased attention in the biomedical field due to their mechanical flexibility, electronic and ionic conductivity. On the other hand, bio-derived polymers such as silk proteins (fibroin and sericin) are an important set of materials to realize mechanically deformable, biocompatible and biodegradable systems. Here, we show a ‘green’ approach to fabricate micropatterned, flexible biosensors using photoreactive silk proteins in conjunction with conductive polymers. A functional ink comprised of poly(3,4-ethylene dioxythiophene: poly(styrene sulfonate) (PEDOT:PSS) with silk sericin as a carrier enables the formation of high resolution conducting micropatterns on a silk fibroin substrate via photolithography. The flexible and conformable organic device formed can be used to sense biomolecules with high sensitivity and selectivity. The micropatterned functional silk composites are made using an all water-based fabrication approach, and shown to be cell friendly and degradable. Such systems can find applications in implantable optical devices, bio-sensors, and bio-optoelectronic devices.

Keywords

biomaterialmicrostructurelithography (deposition)
Type
Articles
Information
MRS Advances , Volume 1 , Issue 52: Soft Materials and Biomaterials , 2016 , pp. 3539 - 3544
Copyright
Copyright © Materials Research Society 2016 

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References

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