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Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis with multiple organ failure

Published online by Cambridge University Press:  27 February 2006

Lionel Riou França ,
Robert Launois ,
Katell Le Lay ,
Philippe Aegerter ,
Myriam Bouhassira ,
Patrick Meshaka  and
Bertrand Guidet
Lionel Riou França
Affiliation:
REES France
Robert Launois
Affiliation:
University of Paris XIII and REES France
Katell Le Lay
Affiliation:
REES France
Philippe Aegerter
Affiliation:
INSERM U707 and Ambroise Paré Hospital
Myriam Bouhassira
Affiliation:
Lilly France
Patrick Meshaka
Affiliation:
Lilly France
Bertrand Guidet
Affiliation:
INSERM U707 and Saint Antoine Hospital
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Abstract

Objectives: The aim of this study was to estimate the expected cost and clinical benefits associated with the use of drotrecogin alfa (activated) (Xigris; Eli Lilly and Company; Indianapolis, IN) in the French hospital setting.

Methods: The recombinant human activated PROtein C Worldwide Evaluation in Severe Sepsis (PROWESS) study results (1,271 patients with multiple organ failure) were adjusted to 9,948 hospital stays from a database of Parisian area intensive-care units (ICUs)—the CubRea (Intensive Care Database User Group) database. The analysis features a decision tree with a probabilistic sensitivity analysis.

Results: The cost per life year gained (LYG) of drotrecogin treatment for severe sepsis with multiple organ failure (European indication) was estimated to be $11,812. At the hospital level, the drug is expected to induce an additional cost of $7,545 per treated patient. The incremental cost-effectiveness ratio ranges from $7,873 per LYG for patients receiving three organ supports during ICU stay to $17,704 per LYG for patients receiving less than two organ supports.

Conclusions: Drotrecogin alfa (activated) is cost-effective in the treatment of severe sepsis with multiple organ failure when added to best standard care. The cost-effectiveness of the drug increases with baseline disease severity, but it remains cost-effective for all patients when used in compliance with the European approved indication.

Keywords

Severe sepsisIntensive careDrotrecogin alfa (activated)Cost-effectivenessHealth care costs
Type
GENERAL ESSAYS
Information
International Journal of Technology Assessment in Health Care , Volume 22 , Issue 1 , January 2006 , pp. 101 - 108
Copyright
© 2006 Cambridge University Press

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