Hostname: page-component-848d4c4894-wg55d Total loading time: 0 Render date: 2024-05-20T00:43:51.001Z Has data issue: false hasContentIssue false
  • English
  • Français

Sudden sensorineural hearing loss as the first manifestation of chronic myeloid leukaemia: case report

Published online by Cambridge University Press:  17 November 2014

M Diao ,
F Tian  and
J Sun
M Diao
Affiliation:
Centre of Otolaryngology of PLA, Navy General Hospital, Beijing, PR China
F Tian
Affiliation:
Centre of Otolaryngology of PLA, Navy General Hospital, Beijing, PR China
J Sun*
Affiliation:
Centre of Otolaryngology of PLA, Navy General Hospital, Beijing, PR China
*
Address for correspondence: Dr J Sun, Fucheng Road 6, Haidian District, Beijing 100048, PR China Fax: 86-10-68780653 E-mail: jjsun85@sina.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Sudden sensorineural hearing loss rarely occurs in patients with chronic myeloid leukaemia.

Case report:

We present a case report of a patient who presented with sudden sensorineural hearing loss as the first manifestation of chronic myeloid leukaemia, and review the mechanisms responsible for sudden sensorineural hearing loss in leukaemic patients.

Results:

A 31-year-old female presented to our clinic with unilateral sudden sensorineural hearing loss and tinnitus. Pure tone audiometry revealed profound sensorineural hearing loss in the left ear at all frequencies. During an investigation into her hearing loss, the patient was found to have chronic myeloid leukaemia.

Conclusion:

Every case of sudden sensorineural hearing loss must be carefully evaluated, and haematological disorders must be considered in the differential diagnosis of sudden hearing loss.

Keywords

Hearing Loss, SuddenTinnitusLeukaemia, Chronic MyeloidHyperbaric Oxygenation
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 11 , November 2014 , pp. 1015 - 1017
Copyright
Copyright © JLO (1984) Limited 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Naithani, R, Chandra, J, Mathur, NN, Narayan, S, Singh, V. Hearing loss in chronic myeloid leukemia. Pediatr Blood Cancer 2005;45:54–6Google Scholar
2Chau, JK, Lin, JR, Atashband, S, Irvine, RA, Westerberg, BD. Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. Laryngoscope 2010;120:1011–21Google Scholar
3Donne, A. Cours de microscopie complementaire des etudes medicales, anotomie, microscopique et, physilolgie des fluides de l ’economie. Paris: JB Bailliere, 1844Google Scholar
4Veling, MC, Windmill, I, Bumpous, JM. Sudden hearing loss as a presenting manifestation of leukemia. Otolaryngol Head Neck Surg 1999;120:954–6Google Scholar
5Baer, MR, Stein, RS, Dessypris, EN. Chronic lymphocytic leukemia with hyperleukocytosis: the hyperviscosity syndrome. Cancer 1985;56:2865–93.0.CO;2-6>CrossRefGoogle ScholarPubMed
6Chae, SW, Cho, JH, Lee, JH, Kang, HJ, Hwang, SJ. Sudden hearing loss in chronic myelogenous leukaemia implicating the hyperviscosity syndrome. J Laryngol Otol 2002;116:291–3CrossRefGoogle ScholarPubMed
7Preston, FE, Sokol, RJ, Lilleyman, JS, Winfield, DA, Blackburn, EK. Cellular hyperviscosity as a cause of neurological symptoms in leukaemia. Br Med 1978;25:76–8Google Scholar
8Gotay, V. Unusual otologic manifestation of chronic lymphocytic leukemia. Laryngoscope 1976;86:1856–63CrossRefGoogle ScholarPubMed
9Paparella, MM, Berlinger, NT, Oda, M, el-Fiky, F. Otological manifestations of leukemia. Laryngoscope 1973; 83:1510–26Google Scholar
10Stucki, A, Rivier, AS, Gikic, M, Monai, N, Schapira, M, Spertini, O. Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. Blood 2001;97:2121–9CrossRefGoogle ScholarPubMed
11Porcu, P, Cripe, LD, Ng, EW, Bhatia, S, Danielson, CM, Orazi, A et al. Hyperleukocytic leukemias and leukostasis: a review of pathophysiology, clinical presentation and management. Leuk Lymphoma 2000;39:1–18CrossRefGoogle ScholarPubMed
12Hsu, YC, Su, CY, Hsu, RF. Unilateral sudden hearing loss as a presenting manifestation of chronic myeloid leukemia: case report. Otolaryngol Head Neck Surg 2004;130:271–3Google Scholar
13Erïkcï, AA, Öztürk, A, Sayan, O. An uncommon presentation of chronic lymphocytic leukemia: bilateral hearing loss. Fırat Medical Journal 2007;12:76–8Google Scholar