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Insulin-like effects of fatty acid synthesis in liver of hamsters infected with plerocercoids of the tapeworm, Spirometra mansonoides

Published online by Cambridge University Press:  18 November 2009

C. Kirk Phares  and
R. M. Carroll
C. Kirk Phares
Affiliation:
Department of Biochemistry, University of Nebraska, Omaha, Nebraska 68105, U.S.A.;
R. M. Carroll
Affiliation:
Department of Comparative Medicine, Bowman Gray Medical School, Winston-Salem, North Carolina 27103, U.S.A.
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Abstract

Elevated serum lipids are associated with infections of laboratory rodents with plerocercoids of Spirometra mansonoides. The effect of infection with these larval tapeworms on triglyceride degradation and hepatic de novo fatty acid synthesis was investigated in Syrian hamsters. Serum lipoprotein electrophoresis revealed a consistent elevation in very low density lipoproteins in the infected animals. Lipoprotein lipase activity was enhanced in the infected animals. After seven days of plerocercoid infection the activity of acetyl-CoA carboxylase (E.C. 6.4.1.2) was significantly elevated after 6,12 and 18 hours of fasting. Fatty acid synthetase was significantly increased after 0,6,12,18 and 24 hours of fasting. Therefore, a chronic insulin-like activity on lipid metabolism of hamsters is associated with plerocercoid infection.

Type
Research Article
Information
Journal of Helminthology , Volume 58 , Issue 1 , March 1984 , pp. 25 - 30
Copyright
Copyright © Cambridge University Press 1984

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