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Diet and cancer prevention: the Concerted Action Polyp Prevention (CAPP) Studies

Published online by Cambridge University Press:  05 March 2007

J. Burn*
Affiliation:
Department of Human Genetics, University of Newcastle, Newcastle upon Tyne NE2 4AA, UK
P. D. Chapman
Affiliation:
Department of Human Genetics, University of Newcastle, Newcastle upon Tyne NE2 4AA, UK
D. T. Bishop
Affiliation:
Genetic Epidemiology Unit, University of Leeds, Leeds LS2 SJT, UK
J. Mathers
Affiliation:
Department of Nutritional and Biological Sciences, University of Newcastle, Newcastle upon Tyne NEI 7RE, UK
*
*Corresponding author: Professor John Burn, fax +44 (0)191 222 7143, email john.burn@ncl.ac.uk
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Abstract

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Type
Plenary Lecture
Copyright
Copyright © The Nutrition Society 1998

References

Bingham, SA (1988) Meat, starch and nonstarch polysaccharides and large bowel cancer. American Journal of Clinical Nutrition 48, 762767.CrossRefGoogle ScholarPubMed
Boolbol, SK, Dannanberg, AJ, Chadburn, A, Martucci, C, Guo, X, Ramonetti, JT, Abreu-Goris, M, Newmark, HL, Lipkin, M, DeCosse, JJ & Bertagnolli, MM (1996) Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of Familial Adenomatous Polyposis. Cancer Research 56, 25562560.Google Scholar
Burkitt, DP (1969) Related disease-related cause. Lancet ii, 12291231.Google Scholar
Burn, J, Chapman, PD, Bertario, L, Bishop, DT, Bülow, S, Cummings, J, Mathers, J, Phillips, R & Vasen, H (1995) A European double-blind trial of aspirin and resistant starch in Familial Adenomatous Polyposis: The CAPP Study. European Journal of Cancer 31A, 13851386 Abstr.CrossRefGoogle ScholarPubMed
Burn, J, Chapman, PD & Eastham, EJ (1994) Familial Adenomatous Polyposis. Archives of Disease in Childhood 71, 103107.CrossRefGoogle ScholarPubMed
Cassidy, A, Bingham, SA & Cummings, JH (1994) Starch intake and colorectal cancer risk an international comparison. British Journal of Cancer 69, 937942.Google Scholar
Davis, AE & Patterson, F (1994) Aspirin reduces the incidence of colonic carcinoma in the dimethylhydrazine rat animal model. Australian and New Zealand Journal of Medicine 24, 301303.Google Scholar
Debinski, HS, Trojan, J, Nugent, KP, Spigelman, AD & Phillips, RKS (1995) Effect of sulindac on small polyps in familial adenomatous polyposis. Lancet 345, 855856.Google Scholar
Delaney, TP, Uknes, S, Vernooij, B, Friedrich, J, Weymann, K, Negrotto, T, Gaffney, T, Gut-rella, M, Kessmann, H, Ward, E & Ryals, J (1994) A central role of salicylic acid in plant disease resistance. Science 266, 12471250.Google Scholar
Dunlop, MG, Farrington, SM, Carothers, AD, Wyllie, AH, Sharp, L, Burn, J, Liu, B, Kinzler, KW & Vogelstein, B (1997) Cancer risk associated with germline DNA mismatch repair gene mutations. Human Molecular Genetics 6, 105110.CrossRefGoogle ScholarPubMed
Elder, DJE, Hague, A, Hicks, DJ & Paraskeva, C (1996) Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma cell lines. Cancer Research 56, 22732276.Google ScholarPubMed
Giardiello, FM (1994) Sulindac and polyp regression. Cancer and Metastasis Reviews 13, 279283.Google Scholar
Giovannucci, E, Egan, KM, Hunter, DJ, Stampfer, MJ, Colditz, GA, Willett, WC & Speizer, FE (1995) Aspirin and the risk of colorectal cancer in women. New England Journal of Medicine 333, 609614.Google Scholar
Giovannucci, E, Rimm, EB, Stampfer, MJ, Colditz, GA, Asherio, A & Willett, WC (1994) Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Annals of Internal Medicine 121, 241246.CrossRefGoogle ScholarPubMed
Hague, A, Manning, AM, Hanlon, KA, Huschtscha, LI, Hart, D & Paraskeva, C (1993) Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway. Implications for the possible role of dietary fibre in the prevention of large-bowel cancer. International Journal of Cancer 55, 498505.CrossRefGoogle Scholar
Janssen, K, Hollman, PC, Reichman, E, Venema, DP, van staveren, WA & Katan, MB (1996) Urinary salicylate excretion in subjects eating a variety of diets shows that amounts of bioavailable salicylates in foods are low. American Journal of Clinical Nutrition 64, 743747.Google Scholar
Järvinen, HJ, Mecklin, JP & Sistonen, P (1995) Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer. Gastroenterology 108, 14051411.Google Scholar
Kolodner, RD, Hall, NR, Lipford, J, Kane, MF, Rao, MRS, Morrison, P, Wirth, L, Finan, PJ, Bum, J, Chapman, P, Earabino, C, Merchant, E, Bishop, DT, Garber, J, Bronner, CE, Baker, SM, Warren, G, Smith, LG, Lindblom, A, Tannergard, P, Bollag, RJ, Godwin, AR, Ward, DC & Nordenskjold, M (1994) Human mismatch repair genes and their association with hereditary non-polyposis colon cancer. Cold Spring Harbor Symposia in Quantitative Biology 59, 331338.Google Scholar
Kruh, J, Tichonicky, L & Defer, N (1994) Effect of butyrate on gene expression. In Short Chain Fatty Acids, pp. 135147 [Binder, HJ, Cummings, J and Soergel, KH, editors]. Lancaster: Kluwer Academic Publishers.Google Scholar
Kune, GA, Kune, S & Watson, LF (1988) Colorectal cancer risk, chronic illness, operations, medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Research 48. 43994404.Google Scholar
Leutwyler, K (1994) Something to chew on. Scientific American 270, 13.Google Scholar
McIntyre, A, Gibson, P & Young, GP (1993) Butyrate production from dietary fibre and protection against large bowel cancer in a rat model. Gut 34, 386391.CrossRefGoogle ScholarPubMed
Oshima, M, Dinchuk, JE, Kargman, SL, Oshima, H, Hancock, B, Kwong, E, Trzaskos, JM, Evans, J & Taketo, MM (1996) Suppression of intestinal polyposis in Apcδ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803809.CrossRefGoogle Scholar
Paganini-Hill, A, Chao, A, Ross, R & Henderson, BE (1989) Aspirin use and chronic diseases: a cohort study of the elderly. British Medical Journal 299, 12471249.Google Scholar
Peleg, II, Maibach, HT, Brown, S & Wilcox, M (1994) Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer. Archives of Internal Medicine 154, 394399.Google Scholar
Piazza, GA, Kulchak Rahm, AL, Krutzsch, M, Sperl, G & Shipp Paranka, N (1995) Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Cancer Research 55, 31103116.Google Scholar
Rosenberg, L, Palmer, JR, Zauber, AG, Warshauer, ME, Stolley, P & Shapiro, S (1991) A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large bowel cancer. Journal of the National Cancer institute 83, 355359.Google Scholar
Scheppach, W (1994) Effects of short chain fatty acids on gut morphology and function. Gut 35, S35S38.Google Scholar
Schreinemachers, D & Everson, RB (1994) Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 5, 138146.Google Scholar
Shiff, SJ, Koutsos, MI, Qiao, L & Rigas, B (1996) Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. Experimental Cell Research 222, 179188.CrossRefGoogle ScholarPubMed
Stephenson, BM, Finan, PJ, Gasgoyne, J, Garbett, F, Murday, V & Bishop, DT (1991) Frequency of familial colorectal cancer. British Journal of Surgery 78, 11621166.Google Scholar
Suh, O, Mettlin, C & Petrelli, NJ (1993) Aspirin use, cancer and polyps of the large bowel. Cancer 72, 11711177.Google Scholar
Thun, MJ, Namboodiri, M & Heath, CW Jr (1991) Aspirin use and reduced risk of fatal colon cancer. New England Journal of Medicine 325, 15931596.CrossRefGoogle ScholarPubMed
van Munster, IP, Tangerman, A & Nagengast, FM (1994) Effect of resistant starch on colonic fermentation, bile acid metabolism, and mucosal proliferation. Digestive Diseases and Sciences 39, 834842.Google Scholar