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Prefrontal cortex dysfunction in patients with suicidal behavior

Published online by Cambridge University Press:  19 October 2006

AURELIE RAUST
Affiliation:
Department of Psychiatry, Chenevier-Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil cedex, France INSERM U 513, Créteil School of Medicine, Créteil cedex, France
FRÉDÉRIC SLAMA
Affiliation:
Department of Psychiatry, Chenevier-Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil cedex, France INSERM U 513, Créteil School of Medicine, Créteil cedex, France
FLAVIE MATHIEU
Affiliation:
INSERM U 513, Créteil School of Medicine, Créteil cedex, France
ISABELLE ROY
Affiliation:
Department of Psychiatry, Chenevier-Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil cedex, France INSERM U 513, Créteil School of Medicine, Créteil cedex, France
ALAIN CHENU
Affiliation:
INSERM U 513, Créteil School of Medicine, Créteil cedex, France
DIEGO KONCKE
Affiliation:
INSERM U 513, Créteil School of Medicine, Créteil cedex, France
DAMIEN FOUQUES
Affiliation:
Department of Psychiatry, Chenevier-Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil cedex, France INSERM U 513, Créteil School of Medicine, Créteil cedex, France
FABRICE JOLLANT
Affiliation:
Department of Psychological Medicine and Psychiatry, Lapeyronie Hospital and INSERM E 0361, Montpellier, France
ERIC JOUVENT
Affiliation:
Department of Neurology, Kremin-Bicètre Hospital, Paris, France
PHILIPPE COURTET
Affiliation:
Department of Psychological Medicine and Psychiatry, Lapeyronie Hospital and INSERM E 0361, Montpellier, France
MARION LEBOYER
Affiliation:
Department of Psychiatry, Chenevier-Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil cedex, France INSERM U 513, Créteil School of Medicine, Créteil cedex, France
FRANK BELLIVIER
Affiliation:
Department of Psychiatry, Chenevier-Mondor Hospital, Assistance Publique-Hôpitaux de Paris, Créteil cedex, France INSERM U 513, Créteil School of Medicine, Créteil cedex, France

Abstract

Background. Abnormal serotonergic neurotransmission has long been demonstrated in suicidal behavior. The dorsal and median raphe nuclei housing the main serotonergic cell bodies and the prefrontal cortex (PFC), particularly the ventral part innervated by the serotonergic system, have therefore been studied extensively in suicidal behavior research. However, only a few studies have described neuropsychological function impairment in suicidal patients. We investigated PFC-related neuropsychological function in patients with suicidal behavior, separating dorsolateral PFC (DLPFC)- and orbitofrontal cortex (OFC)-related functions.

Method. We compared 30 euthymic patients with suicidal behavior aged 18–65 years with 39 control subjects, for the following neuropsychological domains: global intellectual functioning, reward sensitivity, initiation, inhibition, and working memory. Patients and controls were compared by means of univariate and multivariate analyses, adjusting for age at interview, level of education and mood state at the time of evaluation. Trait impulsivity, measured with the Barratt Impulsivity Scale version 10 (BIS-10), was also included as a covariate in a subset of analyses.

Results. Multivariate comparisons demonstrated significant executive function deficits in patients with suicidal behavior. In particular, we observed impairment in visuospatial conceptualization (p<0·0001), spatial working memory (p=0·001), inhibition (Hayling B–A, p=0·04; go anticipations, p=0·01) and visual attention (or reading fluency) (p=0·002). Similar results were obtained following adjustment for motor impulsivity as a covariate, except for spatial working memory.

Conclusions. These deficits are consistent with prefrontal dysfunction in patients with suicidal behavior. Differentiation between DLPFC- and OFC-related neuropsychological functions showed no specific dysfunction of the orbitofrontal region in patients with suicidal behavior in our sample.

Type
Original Article
Copyright
2006 Cambridge University Press

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