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Antioxidant vitamins and minerals in prevention of cancers: lessons from the SU.VI.MAX study

Published online by Cambridge University Press:  08 March 2007

Serge Hercberg*
Affiliation:
U557 Inserm (UMR Inserm/Inra/CNAM), Institut Scientifique et Technique de la Nutrition et de l'Alimentation/CNAM, 5 rue Vertbois, F-75003 Paris, France Unité de Surveillance et d'Epidémiologie Nutritionnelle (USEN), InVS/CNAM, Paris, France
Sebastien Czernichow
Affiliation:
U557 Inserm (UMR Inserm/Inra/CNAM), Institut Scientifique et Technique de la Nutrition et de l'Alimentation/CNAM, 5 rue Vertbois, F-75003 Paris, France
Pilar Galan
Affiliation:
U557 Inserm (UMR Inserm/Inra/CNAM), Institut Scientifique et Technique de la Nutrition et de l'Alimentation/CNAM, 5 rue Vertbois, F-75003 Paris, France
*
*Corresponding author: Dr Serge Hercberg, email: hercberg@cnam.fr
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Abstract

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A voluminous body of epidemiological research concerning the potential role of antioxidant nutrients in the prevention of cancers has accumulated over the past few decades. However, results of large recent intervention trials do not support a preventive effect against cancer for supplementation with antioxidant nutrients. Seemingly contradictory results between observational studies and randomised trials can be explained by the fact that doses used in clinical trials were much higher than the highest levels attained by the usual dietary intake which, in observational studies, were found to be associated with the lowest risk of cancer. Recently, the Supplementation en Vitamines et Mine´raux Antioxydants (SU.VI.MAX) study, a randomised, double-blind, placebo-controlled primary prevention trial, tested the efficacy of supplementation with a combination of antioxidant vitamins and minerals, at nutritional doses, in reducing the cancer incidence in a general population not selected for risk factors. After 7·5 years, low-dose antioxidant supplementation lowered the total cancer incidence in men only. This may be explained by a lower baseline status of certain antioxidants in men compared to women. Finally, the effect of antioxidant supplementation on the incidence of cancer could depend on baseline antioxidant status (which differs from gender and/or nutritional status) and the health status of subjects (healthy v. cancer high-risk subjects). Antioxidant supplementation may have a beneficial effect upon cancer incidence only in healthy subjects who are not exposed to cancer risk and who have a particularly low baseline status. High doses of antioxidant supplementation may be deleterious in subjects in whom the initial phase of cancer development has already started, and they could be ineffective in well-nourished subjects with adequate antioxidant status.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2006

References

ATBC Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330, 10291035.CrossRefGoogle Scholar
Blot, WJ, Li, JY & Taylor, PR (1993) Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 85, 14831492.CrossRefGoogle ScholarPubMed
Diplock, AT (1991) Antioxidant nutrients and disease prevention: an overview. Am J Clin Nutr 53 189S – 193SGoogle Scholar
Galan, P, Briancon, S & Favier, A (2005) Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?. Br J Nutr 94, 125132.Google Scholar
Hennekens, CH, Buring, JE & Manson, JE (1996) Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334, 11451149.CrossRefGoogle ScholarPubMed
Hercberg, S, Galan, P, Preziosi, P, Alfarez, MJ & Vazquez, C (1998 a) The potential role of antioxidant vitamins in preventing cancers. Nutrition 15, 513520.CrossRefGoogle Scholar
Hercberg, S, Galan, P, Preziosi, P, Bertrais, S, Mennen, L, Malvy, D, Roussel, AM, Favier, A & Briançon, S (2004) The SU.VI.MAX study: a randomised, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 164, 23352343.Google Scholar
Hercberg, S, Galan, P, Preziosi, P, Roussel, A-M, Arnaud, J, Richard, M-J, Malvy, D, Paul-Dauphin, A & Briançon, S & Favier, A (1998 c) Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. Int J Vitam Nutr Res 68, 320.Google ScholarPubMed
Hercberg, S, Preziosi, P, Briançon, S, Galan, P, Paul-Dauphin, A, Malvy, D, Roussel, A-M & Favier, A (1998 b) A primary prevention trial of nutritional doses of antioxidant vitamins and minerals on cardiovascular diseases and cancers in general population: the SU.VI.MAX study. Design, methods and participant characteristics. Control Clin Trials 19, 336351.CrossRefGoogle ScholarPubMed
Lee, IM, Cook, NR, Manson, JE, Buring, JE & Hennekens, CH (1999) β-Carotene supplementation and incidence of cancer and cardiovascular disease: The Women's Health Study. J Natl Cancer Inst 24, 21022106.CrossRefGoogle Scholar
Omenn, GS, Goodman, GE & Thorquist, MD (1996) Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334, 11501155.CrossRefGoogle ScholarPubMed