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Is reversal of endothelial dysfunction by tea related to flavonoid metabolism?

Published online by Cambridge University Press:  08 March 2007

Jonathan M. Hodgson*
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, and the Western Australian Institute for Medical Research (WAIMR), Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
Ian B. Puddey
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, and the Western Australian Institute for Medical Research (WAIMR), Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
Valerie Burke
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, and the Western Australian Institute for Medical Research (WAIMR), Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
Kevin D. Croft
Affiliation:
School of Medicine and Pharmacology, University of Western Australia, and the Western Australian Institute for Medical Research (WAIMR), Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
*
*Corresponding author: Dr Jonathan M. Hodgson, University of Western Australia, fax +61 8 9224 0246, email jonathan@cyllene.uwa.edu.au
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Abstract

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Dietary flavonoids can improve endothelial function, but the response varies between individuals. Wide variability is also seen in flavonoid O-methylation, a major pathway of flavonoid metabolism. The O-methylation of flavonoids could alter activity, and thus influence any effect on endothelial function. The objective of the current analysis was to investigate whether variability in the endothelial function response to ingestion of tea, a rich source of flavonoids, is related to the degree of O-methylation of flavonoids. This relationship was investigated in two studies in which endothelium-dependent flow-mediated dilatation (FMD) of the brachial artery was assessed and urinary 4-O-methylgallic acid (4OMGA) excretion was used as a marker of the O-methylation of tea-derived flavonoids. In the first study, amongst participants consuming five cups of tea per day for 4 weeks, the degree of increase in 4OMGA excretion was inversely associated with the change in FMD responses (r −078, p=0·008). In the second study, there was a significant difference in the FMD responses to acute ingestion of three cups of tea between individuals with a low (<median) and high (>median) 4OMGA response (1·94 (sem 0·79) % and −0·25 (sem 0·53) %, respectively; p=0·03). That is, any improvement in FMD following ingestion of tea may be enhanced in individuals who O-methylate less of the absorbed flavonoids. The present results are consistent with the suggestion that differences in flavonoid metabolism may influence their effect on endothelial function. Thus, differences in flavonoid metabolism could be related to the level of benefit of dietary flavonoids on the risk of CVD.

Type
Short Communication
Copyright
Copyright © The Nutrition Society 2006

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