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The effect of retinyl palmitate added to iron-fortified maize porridge on erythrocyte incorporation of iron in African children with vitamin A deficiency

Published online by Cambridge University Press:  09 March 2007

Lena Davidsson*
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, PO Box 474, CH-8803 Rüschlikon, Switzerland and Institut National de Santé Publique, Adjamé, PO Box 47, 01 Abidjan, Côte d'Ivoire
Pierre Adou
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, PO Box 474, CH-8803 Rüschlikon, Switzerland and Institut National de Santé Publique, Adjamé, PO Box 47, 01 Abidjan, Côte d'Ivoire
Christophe Zeder
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, PO Box 474, CH-8803 Rüschlikon, Switzerland and Institut National de Santé Publique, Adjamé, PO Box 47, 01 Abidjan, Côte d'Ivoire
Thomas Walczyk
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, PO Box 474, CH-8803 Rüschlikon, Switzerland and Institut National de Santé Publique, Adjamé, PO Box 47, 01 Abidjan, Côte d'Ivoire
Richard Hurrell
Affiliation:
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, PO Box 474, CH-8803 Rüschlikon, Switzerland and Institut National de Santé Publique, Adjamé, PO Box 47, 01 Abidjan, Côte d'Ivoire
*
*Corresponding author: Dr Lena Davidsson, fax +41 1 704 5710, email lena.davidsson@ilw.agrl.ethz.ch
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Abstract

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Retinyl palmitate added to Fe-fortified maize bread has been reported to enhance Fe absorption in adult Venezuelan subjects but not in Western Europeans. It is not known to what extent these results were influenced by differences in vitamin A status of the study subjects. The objective of the present study was to evaluate the influence of retinyl palmitate added to Fe-fortified maize porridge on erythrocyte incorporation of Fe in children with vitamin A deficiency, before and after vitamin A supplementation. Erythrocyte incorporation of Fe-stable isotopes was measured 14 d after intake of maize porridge (2·0 mg Fe added as ferrous sulfate) with and without added retinyl palmitate (3·5 μmol; 3300 IU). The study was repeated 3 weeks after vitamin A supplementation (intake of a single dose of 210 μmol retinyl palmitate; ‘vitamin A capsule’). Vitamin A status was evaluated by the modified relative dose–response (MRDR) technique. Retinyl palmitate added to the test meal reduced the geometric mean erythrocyte incorporation of Fe at baseline from 4·0 to 2·6 % (P=0·008, n 13; paired t test). At 3 weeks after vitamin A supplementation, geometric mean erythrocyte incorporation was 1·9 and 2·3 % respectively from the test meal with and without added retinyl palmitate (P=0·283). Mean dehydroretinol:retinol molar ratios were 0·156 and 0·125 before and after intake of the single dose of 210 μmol retinyl palmitate; ‘vitamin A capsule’ (P=0·15). In conclusion, retinyl palmitate added to the labelled test meals significantly decreased erythrocyte incorporation of Fe in children with vitamin A deficiency at baseline but had no statistically significant effect 3 weeks after vitamin A supplementation. The difference in response to retinyl palmitate added to Fe-fortified maize porridge on erythrocyte incorporation of Fe before and after intake of the vitamin A capsule indicates, indirectly, changes in vitamin A status not measurable by the MRDR technique. The lack of conclusive data on the effect of retinyl palmitate on Fe absorption indicates the complexity of the interactions between vitamin A status, dietary vitamin A and Fe metabolism.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2003

References

Amine, EK, Corey, J, Hegsted, DM & Hayes, KC (1970) Comparative hematology during deficiencies of iron and vitamin A in the rat. J Nutr 100, 10331040.CrossRefGoogle ScholarPubMed
Beer, B & Heumann, KG (1993) Isotope dilution mass spectrometry of microelectronically relevant heavy metal traces in high purity cobalt. Fresenius J Anal Chem 347, 351355.CrossRefGoogle Scholar
Cook, JD, Layrisse, M, Martinez-Torres, C, Walker, R, Monsen, E & Finch, CA (1972) Food iron absorption measured by an extrinsic tag. J Clin Invest 51, 805815.CrossRefGoogle ScholarPubMed
Davidsson, L, Galan, P & Kastenmayer, P (1994) Iron bioavailability in infants: The influence of phytic acid and ascorbic acid in infant formulas based on soy isolate. Pediatr Res 36, 816822.CrossRefGoogle ScholarPubMed
Fishman, SM, Christian, P & West, KP Jr (2000) The role of vitamins in the prevention and control of anaemia. Public Health Nutr 3, 125150.CrossRefGoogle ScholarPubMed
Garcia-Casal, MN, Layrisse, M, Solano, L et al. (1998) Vitamin A and beta-carotene can improve nonheme iron absorption from rice, wheat and corn by humans. J Nutr 128, 646650.CrossRefGoogle ScholarPubMed
Hallberg, L & Björn-Rasmussen, E (1972) Determination of iron absorption from whole diet. A new two-pool model using two radioiron isotopes given as haem and non-haem iron. Scand J Haematol 9, 193197.CrossRefGoogle Scholar
Kastenmayer, P, Davidsson, L, Galan, P, Cherouvrier, F, Hercberg, S & Hurrell, RF (1994) A double stable isotope technique for measuring iron absorption in infants. Br J Nutr 71, 411424.CrossRefGoogle ScholarPubMed
Layrisse, M, Garcia-Casal, MN, Solano, L et al. (1997) The role of vitamin A on the inhibitors of nonheme iron absorption: preliminary results. J Nutr Biochem 8, 6167.CrossRefGoogle Scholar
Linderkamp, O, Versmold, HT, Riegel, KP & Betke, K (1977) Estimation and prediction of blood volume in infants and children. Eur J Pediatr 125, 227234.CrossRefGoogle ScholarPubMed
Mejia, LA, Hodges, RE & Rucker, RB (1979) Role of vitamin A in the absorption, retention and distribution of iron in the rat. J Nutr 109, 129137.CrossRefGoogle ScholarPubMed
Roodenburg, AJC, West, CE, Yu, S & Beynen, AC (1994) Comparison between time-dependent changes in iron metabolism of rats as induced by marginal deficiency of either vitamin A or iron. Br J Nutr 71, 687699.CrossRefGoogle ScholarPubMed
Sandberg, A-S & Ahderinne, R (1986) HPLC method for determination of inositol tri-, tetra-, penta-, and hexaphosphates in foods and intestinal contents. J Food Sci 51, 547550.CrossRefGoogle Scholar
Semba, RD & Bloem, MW (2002) The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur J Clin Nutr 56, 271281.CrossRefGoogle Scholar
Sommer, A & Davidson, FR (2002) Assessment and control of vitamin A deficiency; the Annecy accords. J Nutr 132, 2845S2850S.CrossRefGoogle ScholarPubMed
Staubli Asobayire F (2000) Development of a food fortification strategy to combat iron deficiency in the Ivory Coast. PhD thesis no. 13730. Zürich, Switzerland: Swiss Federal Institute of Technology (ETH).Google Scholar
Staubli Asobayire, F, Adou, P, Davidsson, L, Cook, JD & Hurrell, RF (2001) Prevalence of iron deficiency, with and without concurrent anemia, in population groups with high prevalence of malaria and other infections in Côte d'Ivoire. Am J Clin Nutr 74, 776782.CrossRefGoogle Scholar
Tanumihardjo, SA (2001) Can lack of improvement in vitamin A status indicators be explained by little or no overall change in vitamin A status of humans?. J Nutr 131, 33163318.CrossRefGoogle ScholarPubMed
Tanumihardjo, SA, Cheng, JC, Permaesih, D et al. (1996 a) Refinement of the modified-relative-dose-response test as a method for assessing vitamin A status in a field setting: experience with Indonesian children. Am J Clin Nutr 64, 966971.CrossRefGoogle Scholar
Tanumihardjo, SA, Muherdiyantiningsih, & Permaesih, D (1994 a) Assessment of the vitamin A status in lactating and in nonlactating, nonpregnant Indonesian women by use of the modified relative dose response (MRDR) assay. Am J Clin Nutr 60, 142147.CrossRefGoogle Scholar
Tanumihardjo, SA, Muhilal, & Yuniar, Y (1990) Vitamin A status in pre-school-age Indonesian children as assessed by the modified relative dose response (MRDR) assay. Am J Clin Nutr 52, 10681072.CrossRefGoogle Scholar
Tanumihardjo, SA, Permaesih, D & Dahro, AM (1994) Comparison of vitamin A status assessment techniques in children from two Indonesian villages. Am J Clin Nutr 60, 136141.CrossRefGoogle ScholarPubMed
Tanumihardjo, SA, Permaesih, D, Muherdiyantiningsih, (1996) Vitamin A status of Indonesian children infected with Ascaris lumbricoides after dosing with vitamin A supplements and albendazole. J Nutr 126, 451457.CrossRefGoogle ScholarPubMed
Taylor, PDP, Maeck, R & De Bièvre, P (1992) Determination of the absolute isotopic composition and atomic weight of a reference sample of natural iron. Int J Mass Spectrom Ion Process 121, 111125.CrossRefGoogle Scholar
Walczyk, T (1997) Iron isotope ratio measurements by negative thermal ionization mass spectrometry. Int J Mass Spectrom Ion Process 161, 217227.CrossRefGoogle Scholar
Walczyk, T, Davidsson, L, Hulthen, L, Hallberg, L & Hurrell, RF (2003) No enhancing effect of vitamin A on iron absorption in healthy adults. Am J Clin Nutr 77, 144149.CrossRefGoogle Scholar
Walczyk, T, Davidsson, L, Zavaleta, N & Hurrell, RF (1997) Stable isotope labels as a tool to determine iron absorption by Peruvian school children from a breakfast meal. Fresenius J Anal Chem 359, 445449.CrossRefGoogle Scholar
Wieringa, FT, Dijkhuizen, M, West, CE, Northrop-Clewes, CA & Muhilal, (2002) Estimation of the effect of the acute phase response on indicators of micronutrient status in Indonesian infants. J Nutr 132, 30613066.CrossRefGoogle ScholarPubMed
Willumsen, JF, Simmank, K, Filteau, SM, Wagstaff, LA & Tomkins, AM (1997) Toxic damage to the respiratory epithelium induces acute phase changes in vitamin A metabolism without depleting retinol stores of South African children. J Nutr 127, 13391343.CrossRefGoogle Scholar