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Blood glucose and meal patterns in time-blinded males, after aspartame, carbohydrate, and fat consumption, in relation to sweetness perception

Published online by Cambridge University Press:  09 March 2007

Kathleen J. Melanson
Affiliation:
Department of Human Biology Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
Margriet S. Westerterp-Plantenga*
Affiliation:
Department of Human Biology Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
L. Arthur Campfield
Affiliation:
Center for Human Nutrition, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Wim H. M. Saris
Affiliation:
Department of Human Biology Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
*
*Corresponding author: Dr Margriet Westerterp-Plantenga, fax +31 43 367 0976, email M.Westerterp@HB.UNIMAAS.NL
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Abstract

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In a study of the impact of aspartame, fat, and carbohydrate on appetite, we monitored blood glucose continuously for 431 (se 16) min. Ten healthy males (19–31 years) participated in three time-blinded visits. As blood glucose was monitored, appetite ratings were scored at randomized times. On the first meal initiation, volunteers consumed one of three isovolumetric drinks (aspartame, 1 MJ simple carbohydrate, and 1 MJ high-fat; randomized order). High-fat and high-carbohydrate foods were available ad libitum subsequently. Blood glucose patterns following the carbohydrate drink (+1·78 (se 0·28) mmol/l in 38 (se 3) min) and high-fat drink (+0·83 (se 0·28) mmol/l in 49 (se 6) min) were predictive of the next intermeal interval (R 0·64 and R 0·97 respectively). Aspartame ingestion was followed by blood glucose declines (40 % of subjects), increases (20 %), or stability (40 %). These patterns were related to the volunteers' perception of sweetness of the drink (R 0·81, P = 0·014), and were predictive of subsequent intakes (R -0·71, P = 0·048). For all drinks combined, declines in blood glucose and meal initiation were significantly associated (χ2 16·8, P < 0·001), the duration of blood glucose responses and intermeal intervals correlated significantly (R 0·715, P = 0·0001), and sweetness perception correlated negatively with hunger suppression (R -0·471, P = 0·015). Effects of fat, carbohydrate, and aspartame on meal initiation, meal size, and intermeal interval relate to blood glucose patterns. Varied blood glucose responses after aspartame support the controversy over its effects, and may relate to sweetness perception.

Type
Research Article
Copyright
Copyright © The Nutrition Society 1999

References

Abdallah, L, Chabert, M & Louis-Sylvestre, J (1997) Cephalic phase responses to sweet taste. American Journal of Clinical Nutrition 65, 737743.CrossRefGoogle ScholarPubMed
Black, RM, Tanaka, P, Leiter, LA & Anderson, GH (1991) Soft drinks with aspartame: effect on subjective hunger, food selection, and food intake of young adult males. Physiology and Behavior 49, 803810.CrossRefGoogle ScholarPubMed
Blundell, JE, Burley, VJ, Cotton, JR & Lawton, CL (1993) Dietary fat and the control of energy intake: evaluating the effects of fat on meal size and postmeal satiety. American Journal of Clinical Nutrition 57, 722S728S.CrossRefGoogle ScholarPubMed
Blundell, JE & Hill, AJ (1986) Paradoxical effects of an intense sweetener (aspartame) on appetite. Lancet i, 10921093.CrossRefGoogle Scholar
Bruce, DG, Storlein, LH, Furler, SM & Chisholm, DJ (1987) Cephalic phase metabolic responses in normal weight adults. Metabolism 36, 721725.CrossRefGoogle ScholarPubMed
Campfield, LA, Brandon, P & Smith, FJ (1985) On-line continuous measurement of blood glucose and meal pattern in free-feeding rats: the role of glucose in meal initiation. Brain Research Bulletin 14, 605616.CrossRefGoogle ScholarPubMed
Campfield, LA, Smith, FJ, Rosenbaum, M & Hirsch, J (1996) Human eating: evidence for a physiological basis using a modified paradigm. Neuroscience and Biobehavioral Reviews 20, 133137.CrossRefGoogle ScholarPubMed
de Graaf, C, Hulshof, T, Weststrate, JA & Jas, P (1992) Short-term effects of different amounts of protein, fats, and carbohydrates on satiety. American Journal of Clinical Nutrition 55, 3338.CrossRefGoogle ScholarPubMed
Driver, CJI (1988) The effect of meal composition on the degree of satiation following a test meal and possible mechanisms involved. British Journal of Nutrition 60, 441449.CrossRefGoogle ScholarPubMed
Flatt, JP (1996) Carbohydrate balance and body weight regulation. Proceedings of the Nutrition Society 55, 449465.CrossRefGoogle ScholarPubMed
Foltin, RW, Fischman, MW, Emurian, CS & Rachlinski, JJ (1988) Compensation for caloric dilution in humans given unrestricted access to food in a residential laboratory. Appetite 10, 1324.CrossRefGoogle Scholar
Foltin, RW, Fischman, MW, Moran, TH, Rolls, BJ & Kelly, TH (1990) Caloric compensation for lunches varying in fat and carbohydrate content by humans in a residential laboratory. American Journal of Clinical Nutrition 52, 969980.CrossRefGoogle Scholar
Gibbs, J & Smith, GP (1986) The roles of peptides from the stomach and the intestine. Federation Proceedings 45, 13911395.Google ScholarPubMed
Herman, CP & Polivy, J (1980) Restrained eating. In Obesity, pp. 208224 [Stunkard, A, editor]. Philadelphia, PA: WB Saunders.Google Scholar
Himaya, A, Fantino, M, Antoine, J-M, Brondel, L & Louis-Sylvestre, J (1997) Satiety power of dietary fat: a new appraisal. American Journal of Clinical Nutrition 65, 14101418.CrossRefGoogle ScholarPubMed
Hulshof, T, de Graaf, C & Weststrate, JA (1993) The effects of preloads varying in physical state and fat content on satiety and energy intake. Appetite 21, 272286.CrossRefGoogle ScholarPubMed
Langhans, W (1996) Role of the liver in the metabolic control of eating: what we know - and what we do not know. Neuroscience and Biobehavioral Reviews 20, 145153.CrossRefGoogle Scholar
Lavin, JH, French, SJ & Read, NW (1997) The effect of sucrose- and aspartame-sweetened drinks on energy intake, hunger and food choice of female, moderately-restrained eaters. International Journal of Obesity 21, 3742.CrossRefGoogle ScholarPubMed
Lawton, CL, Burley, VJ, Wales, JK & Blundell, JE (1993) Dietary fat and appetite control in obese subjects: weak effects on satiation and satiety. International Journal of Obesity 17, 409416.Google Scholar
Louis-Sylvestre, J & LeMagnen, J (1980) A fall in blood glucose level precedes meal onset in free-feeding rats. Neuroscience and Biobehavioral Reviews 4, 1315.CrossRefGoogle ScholarPubMed
Lucas, F, Bellisle, F & Di Maio, A (1987) Spontaneous insulin fluctuations and the preabsorptive insulin response to food ingestion in humans. Physiology and Behavior 40, 631636.CrossRefGoogle ScholarPubMed
Mattes, R (1990) Effects of aspartame and sucrose on hunger and energy intake in humans. Physiology and Behavior 47, 10371044.CrossRefGoogle ScholarPubMed
Mayer, J (1953) Glucostatic mechanisms in the regulation of food intake. New England Journal of Medicine 249, 1316.CrossRefGoogle ScholarPubMed
Melanson, KJ, Westerterp, MS, Smith, FJ, Campfield, LA & Saris, WHM (1999) Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat. American Journal of Physiology 46, R337R345.Google Scholar
Meyer, JH & Grossman, MI (1972) Comparison of d- and l-phenylalanine as pancreatic stimulants. American Journal of Physiology 222, 10581063.CrossRefGoogle ScholarPubMed
Ministerie van Welzijn, Volksgezondheid en Cultuur en het ministerie van Landbouw en Visserij (1988) Wat eet Nederland: Resultaten van de voedselconsumptiepeiling 1987–1988 (What the Dutch Eat: Results from the Food Consumption Survey 1987–1988). The Hague, The Netherlands: Ministerie van Welzijn.Google Scholar
Parker, RE (1986) Introductory Statistics for Biology, 2nd ed. London: Edward Arnold.Google Scholar
Raben, A, Holst, JJ, Christiansen, NJ & Astrup, A (1996) Determinants of postprandial appetite sensations: macronutrient intake and glucose metabolism. International Journal of Obesity 20, 161169.Google ScholarPubMed
Rodin, J (1990) Comparative effects of fructose, aspartame, glucose, and water preloads on calorie and macronutrient intake. American Journal of Clinical Nutrition 51, 428435.CrossRefGoogle ScholarPubMed
Rogers, PJ, Carlyle, J, Hill, AJ & Blundell, JE (1988) Uncoupling sweet taste and calories: comparison of the effects of glucose and three intense sweeteners on hunger and food intake. Physiology and Behavior 43, 547552.CrossRefGoogle ScholarPubMed
Rogers, PJ, Pleming, HC & Blundell, JE (1990) Aspartame ingested without tasting inhibits hunger and food intake. Physiology and Behavior 47, 12391243.CrossRefGoogle ScholarPubMed
Rolls, BJ (1991) Effects of intense sweeteners on hunger, food intake, and body weight: a review. American Journal of Clinical Nutrition 53, 872881.CrossRefGoogle ScholarPubMed
Rolls, BJ (1995) Carbohydrates, fat and satiety. American Journal of Clinical Nutrition 62, 1086S1095S.CrossRefGoogle Scholar
Rolls, BJ, Hetherington, M & Laster, LJ (1988) Comparison of the effects of aspartame and sucrose on food intake. Appetite 11, Suppl. 1, 6267.CrossRefGoogle ScholarPubMed
Rolls, BJ, Kim, S & Fedoroff, IC (1990) Effects of drinks sweetened with sucrose or aspartame on hunger, thirst, and food intake in men. Physiology and Behavior 48, 1926.CrossRefGoogle ScholarPubMed
Rolls, BJ, Kim, S, McNelis, AL, Fischman, MW, Foltin, RW & Moran, TH (1991) Time course of effects of preloads high in fat or carbohydrate on food intake and hunger ratings in humans. American Journal of Physiology 260, R756R763.Google ScholarPubMed
Sjöström, L, Garellick, G, Krotkiewski, M & Luyckx, A (1980) Peripheral insulin in response to the sight and smell of food. Metabolism 29, 901909.CrossRefGoogle Scholar
Steffens, AB (1970) Plasma insulin content in relation to blood glucose level and meal pattern in the normal and hypothalamic hyperphagic rat. Physiology and Behavior 5, 147151.CrossRefGoogle ScholarPubMed
Stunkard, AJ & Messick, S (1985) The three-factor eating questionnaire to measure dietary restraint and hunger. Journal of Psychosomatic Research 29, 7183.CrossRefGoogle ScholarPubMed
Teff, KL, Devine, J & Engelman, K (1995) Sweet taste: effect on cephalic phase insulin release in men. Physiology and Behavior 57, 10891095.CrossRefGoogle ScholarPubMed
Teff, KL, Mattes, RD & Engelman, K (1991) Cephalic phase insulin release in normal weight males: verification and reliability. American Journal of Physiology 216, E430E436.Google Scholar
Tordoff, MG & Alleva, AM (1990) Oral stimulation with aspartame increases hunger. Physiology and Behavior 47, 555559.CrossRefGoogle ScholarPubMed
van Amelsvoort, JMM, van Stratum, P, Kraal, JH, Lussenburg, RN & Houtsmuller, UMT (1990) Effects of meal size reduction on postprandial variables in male volunteers. Annals of Nutrition and Metabolism 34, 163174.CrossRefGoogle ScholarPubMed
Van Itallie, TB, Yang, M-U & Porikos, KP (1988) Use of aspartame to test the "Body weight set point" hypothesis. Appetite 11, Suppl. 1, 6872.CrossRefGoogle ScholarPubMed
Warwick, ZS, Hall, WG, Pappas, TN & Schiffman, SS (1993) Taste and smell sensations enhance the satiating effect of both a high-carbohydrate and a high-fat meal in humans. Physiology and Behavior 53, 553563.CrossRefGoogle Scholar
Westerterp-Plantenga, MS, Rolland, V, Wilson, SAJ & Westerterp, KR (1999) Satiety related to 24-hour diet-induced thermogenesis during high protein/high carbohydrate versus high fat diets, measured in a respiration chamber European Journal of Clinical Nutrition 53, 495502.CrossRefGoogle Scholar