Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-16T13:58:50.088Z Has data issue: false hasContentIssue false
  • English
  • Français

Tissue engineering of the gastrointestinal tract for surgical replacement: a nutrition tool of the future?

Published online by Cambridge University Press:  05 March 2007

Tracy C. Grikscheit
Tracy C. Grikscheit*
Affiliation:
Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA
*
Corresponding author: Dr Tracy Grikscheit, fax +1 801 730 9061, tgrikscheit@partners.org
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Optimal nutrition depends on the multiple complex functions performed by the gastrointestinal tract, which range from basic functions such as storage, conduit and mechanical processing to more finely regulated capabilities such as vectorial transport, immune defence and cell signalling. Surgical strategies to supply lacking gastrointestinal tract tissues have relied on either replacement by proxy (surgical substitution) or the introduction of prostheses. Tissue engineering seeks to replace missing tissues with engineered tissues that more accurately reproduce the native physiological and anatomical milieu. It is now possible to engineer several areas of the gastrointestinal tract with high fidelity, and to employ tissue-engineered bowel in replacement in animal models. These replacement models have reflected excellent anatomical and physiological recapitulation of native bowel by the tissue-engineered constructs in vivo.

Keywords

Tissue engineeringGastrointestinal tract replacementAnimal models
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 3 , August 2003 , pp. 739 - 743
Copyright
Copyright © The Nutrition Society 2003

References

Bader, A, Schilling, T, Tebken, OE, Brandes, G, Herden, T, Steinhoff, G & Haverich, A (1998) Tissue engineering of heart valves – human endothelial cell seeding of detergent acellularized porcine valves. European Journal of Cardiothoracic Surgery 14, 279–284.CrossRefGoogle ScholarPubMed
Balis, UJ, Behnia, K, Dwarakanath, B, Bhatia, SN, Sullivan, SJ, Yarmush, ML & Toner, M (1999) Oxygen consumption characteristics of porcine hepatocytes. Metabolic Engineering 1, 49–62.CrossRefGoogle ScholarPubMed
Belsey, R (1965) Reconstruction of the esophagus with left colon. Journal of Thoracic Surgery 49, 33–55.CrossRefGoogle ScholarPubMed
Bhatia, SN, Balis, UJ, Yarmush, ML & Bhatia, K (1998) Probing heterotypic cell interactions: Hepatocyte function in microfabricated co-cultures. Journal of Biomaterial Science Polymer Edition 9, 1137–1160.CrossRefGoogle ScholarPubMed
Borenstein, JT, Wu, KS & Shay, PA (1997) Structural characterization of p++ Si:B layers for bulk micromachining. Materials for mechanical and optical microsystems: Proceedings of the Materials Research Society Symposium 20 – 22 Warrendale, PA Materials Research Society Press.Google Scholar
Buckley, MJ, Banes, AJ & Jordan, R (1998) Effects of mechanical strain on osteoblasts in vitro. Journal of Oral Maxillofacial Surgery 48, 276–282.CrossRefGoogle Scholar
Bueno, J, Ohwada, S, Kocoshis, S, Mazariegos, GV, Dvorchik, I, Sigurdsson, L, Di Lorenzo, C, Abu-Elmagd, K & Reyes, J (1999) Factors impacting on the survival of children. Intestinal failure referred for intestinal transplantation. Journal of Pediatric Surgery 34, 27–33.CrossRefGoogle ScholarPubMed
Choi, RS, Riegler, M, Pothoulakis, C, Kim, BS, Mooney, D, Vacanti, M & Vacanti, JP (1998) Studies of brush border enzymes, basement membrane components, and electrophysiology of tissue-engineered neointestine. Journal of Pediatric Surgery 33, 991–997.CrossRefGoogle ScholarPubMed
Diego, MD, Miguel, E, Lucen, CM, Salgado, GM, Martinez, JL & Garrido, HG (1982) Short gut syndrome: A new surgical technique and ultrastructural study of the liver and the pancreas. Archives of Surgery 117, 789–795.CrossRefGoogle Scholar
Dreuw, B, Fass, J, Titkova, S, Anurov, M, Polivoda, M, Ottinger, AP & Schumpelick, V (2001) Colon interposition for esophageal replacement: Isoperistaltic or antiperistaltic? Experimental results. Annals of Thoracic Surgery 71, 303–308.CrossRefGoogle ScholarPubMed
Folch, A, Ayon, A, Hurtado, O, Schmidt, MA & Toner, M (1999) Molding of deep polydimethylsiloxane microstructures for microfluidics and biological applications. Journal of Biomechanical Engineering 121, 28–34.CrossRefGoogle ScholarPubMed
Freed, LE & Vunjak-Novakovic, G (1997) Microgravity tissue engineering in vitro. Cell Development Biology 33, 381–385.Google Scholar
Grikscheit, T, Alsberg, E, Mooney, D & Vacanti, J (2003 a) Experimental tissue engineered small intestine improves recovery after massive small bowel resection. In: Proceedings of the American Pediatric Surgery Association Meeting, Phoenix, Arizona 2002 10–11 Phoenix, AZ American Pediatric Surgical Association PressGoogle Scholar
Grikscheit, T, Gaissert, H & Vacanti, JP (2003 b) Tissue engineered esophagus: Substitution by onlay patch or interposition. Journal of Thoracic and Cardiovascular Surgery (In the Press).CrossRefGoogle ScholarPubMed
Grikscheit, TC, Ochoa, ER, Ramsanahie, A, Whang, EE & Vacanti, JP (2001) Tissue engineered colon, characterization and comparison to native colon. Owen Wangensteen Surgical Forum Abstracts 52, 160–161.Google Scholar
Grikscheit, T, Ogilvie, J, Alsberg, E, Mooney, D & Vacanti, JP (2003 c) Tissue-engineered juvenile spleen protective against pneumococcal infection. Journal of Surgical Research Suppl.(In the Press).Google Scholar
Grikscheit, T, Ogilvie, J, Ochoa, E, Alsberg, E & Vacanti, JP (2002) Tissue engineered colon exhibits function in vivo. Surgery 132, 200–204.CrossRefGoogle ScholarPubMed
Grikscheit, T & Vacanti, JP (2002) The history and current status of tissue engineering: the future of pediatric surgery. Journal of Pediatrics Surgery 37, 277–288.CrossRefGoogle ScholarPubMed
Grikscheit, T & Vacanti, JP (2003) Tissue-engineered stomach from autologous and syngeneic tissue. Journal of Surgical Research Suppl.(In the Press).Google Scholar
Gupta, S, Aragona, E, Vemuru, RP, Bhargava, KK, Burk, RD & Chowdhury, JR (1991) Permanent engraftment and function of hepatocytes delivered to the liver: Implications for gene therapy and liver repopulation. Hepatology 14, 144–149.CrossRefGoogle Scholar
Gutschow, C, Collard, JM, Romagnoli, R, Salizzoni, M & Holscher, A (2001) Denervated stomach as an esophageal substitute recovers intraluminal acidity with time. Annals of Surgery 233, 509–514.CrossRefGoogle ScholarPubMed
Jurkiewicz, MJ & Paletta, CE (1989) Free jejunal graft. In Current Therapy in Cardiothoracic Surgery, pp. 206 – 209 [Grillo, HC, editor]. Toronto, Ont.: Decker.Google Scholar
Kaihara, S, Borenstein, J, Koka, R, Lalan, S, Ochoa, ER, Ravens, M, Pien, H, Cunningham, B & Vacanti, JP (2000 a) Silicon micromachining to tissue engineer branched vascular channels for liver fabrication. Tissue Engineering 6, 105–117.CrossRefGoogle ScholarPubMed
Kaihara, S, Kim, SS, Kim, BS, Mooney, D, Tanaka, K & Vacanti, JP (2000 b) Long-term follow-up of tissue engineered intestine after anastomosis to native small bowel. Transplantation 69, 1927–1932.CrossRefGoogle ScholarPubMed
Kim, SS, Kaihara, S, Benvenuta, M, Choi, RS, Kim, BS, Mooney, DJ, Taylor, GA & Vacanti, JP (1999) Regenerative signals for tissue engineered small intestine. Transplantation Proceedings 31, 657–660.CrossRefGoogle ScholarPubMed
Lanza, RP, Langer, R, Vacanti, J (2000) Principles of Tissue Engineering, San Diego, CA: Academic Press.Google Scholar
Lee, IW, Vacanti, JP & Yoo, J (1997) A tissue engineering approach for dural and cranial grafts. Abstracts of the Congress of Neurological Surgeons.Google Scholar
Matas, AJ, Sutherland, DER, Stefes, MW, Mauer, SM, Sowe, A, Simmons, RL & Najarian, JS (1976) Hepatocellular transplantation for metabolic deficiencies: Decrease in plasma bilirubin in Gunn rats. Science 192, 892–894.CrossRefGoogle ScholarPubMed
Mooney, DJ & Langer, R (1995) Engineering biomaterials for tissue engineering: The 10–100 micron size scale. In The Biomedical Engineering Handbook, pp. 1609 – 1616 [Bronzino, JD, editor]. Boca Raton, FL: CRC Press.Google Scholar
Moskowitz, RL, Shepherd, NA & Nicholls, RJ (1986) An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir. International Journal of Colorectal Disease 1, 167–174.CrossRefGoogle Scholar
O'Brien, MF, Goldstein, S, Walsh, S, Black, KS, Elkins, R & Clarke, D (1999) The synergraft valve: a new acellular (nongluteraldehyde-fixed) tissue heart valve for autologous recellularization first experimental studies before implantation. Seminars in Thoracic and Cardiovascular Surgery 11, 194–200.Google Scholar
Perez, A, Grikscheit, TC, Blumberg, RS, Ashley, SW, Vacanti, JP & Whang, EE (2002) Tissue engineered small intestine: Ontogeny of the immune system. Transplantation 74, 619–623.CrossRefGoogle ScholarPubMed
Pokorny, WJ, Fowler, CJ (1991) Isoperistaltic intestinal lengthening for short bowel syndrome. Surgery Gynecology and Obstetrics 172, 39–43.Google ScholarPubMed
Russell, PS (1985) Selective transplantation. Annals of Surgery 201, 255–262.CrossRefGoogle ScholarPubMed
Samuel, M, Burge, DM & Moore, I (2001) Gastric tube graft interposition as an oesophageal substitute. Australian and New Zealand Journal of Surgery 71, 56–61.CrossRefGoogle ScholarPubMed
Shen, B, Achkar, JP, Lashner, BA, Ormsby, AH, Remzi, FH, Bevins, CL, Brzezinski, A, Petras, RE & Fazio, VW (2001) Endoscopic and histologic evaluation together with symptom assessment are required to diagnose pouchitis. Gastroenterology 121, 261–267.CrossRefGoogle ScholarPubMed
Shinoka, T, Imai, Y & Ikada, Y (2001) Transplantation of a tissue engineered pulmonary artery (letter to the Editor). New England Journal of Medicine 344, 532–533.CrossRefGoogle Scholar
Sutherland, DER, Numata, M, Matas, AJ, Simmons, RL & Najarian, JS (1977) Hepatocellular transplantation in acute liver failure. Surgery 82, 124–132.Google ScholarPubMed
Tavakkolizadeh, A, Stephen, AE, Kaihara, S & Kim, S (2000) Epithelial transporter mRNA expression topography in the tissue-engineered small intestine. Owen Wangensteen Abstracts of the American College of Surgeons Surgical Forum 51, 59–61.Google Scholar
Thompson, JS, Vanderhoot, JA, Antonson, DL, Newland, JR & Hodgson, P (1984) Comparison of techniques for growing small bowel neomucosa. Journal of Surgery Research 36, 401–406.CrossRefGoogle ScholarPubMed
Uyama, S, Kaufmann, PM & Takeda, T (1993) Delivery of whole liver-equivalent hepatocyte mass using polymer devices and hepatotrophic stimulation. Transplantation 55, 932–935.CrossRefGoogle ScholarPubMed
Vacanti, JP, Morse, MA, Saltzman, WM, Domb, AJ, Perez-Atayde, A & Langer, R (1988) Selective cell transplantation using bioabsorbable artificial polymers as matrices. Journal of Pediatric Surgery 23, 3–9.CrossRefGoogle ScholarPubMed
Vandenburgh, H Del Tatto, M, Shansky, J, LeMaire, J & Raven, L (1997) Tissue engineered skeletal muscle organoids for reversible gene therapy. Human Gene Therapy 7, 2195–2200.CrossRefGoogle Scholar
Wang, DL, Wung, BS & Peng, YC & Wang, JJ (1996) Mechanical strain increases endothelin-1 gene expression via protein kinase C pathway in human endothelial cels. Journal of Cell Physiology 163, 400–406.CrossRefGoogle Scholar
Weber, TR, Vane, DW & Grosfeld, JL (1982) Tapering enteroplasty in infants with bowel atresia and short gut. Archives of Surgery 117, 684–688.CrossRefGoogle ScholarPubMed
Wilmore, DW, Byrne, TA & Persinger, RL (1997) Short bowel syndrome: New therapeutic approaches. Currents Problems in Surgery 34, 389–444.CrossRefGoogle ScholarPubMed
Zhang, S, Yan, L, Altman, M, Lassle, M, Nugent, H, Frankel, F, Lauffenburger, DA, Whitesides, GM & Rich, A (1999) Biological surface engineering: a simple system for cell pattern formation. Biomaterials 20, 1213–1220.CrossRefGoogle ScholarPubMed