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Comparison of the novel compounds creatine and pyruvateon lipid and protein metabolism in broiler chickens

Published online by Cambridge University Press:  07 February 2011

J. Chen ,
M. Wang ,
Y. Kong ,
H. Ma  and
S. Zou
J. Chen
Affiliation:
Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, People's Republic of China
M. Wang
Affiliation:
Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, People's Republic of China
Y. Kong
Affiliation:
Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, People's Republic of China
H. Ma*
Affiliation:
Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, People's Republic of China
S. Zou
Affiliation:
Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, People's Republic of China
*
†E-mail: mahaitian@njau.edu.cn
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Abstract

The effects of pyruvate (Pyr), creatine pyruvate (Cr-Pyr) and creatine (Cr) on lipid and protein metabolism were compared in broiler chickens. A total of 400 1-day-old male birds (Aconred) were allocated to four groups, each of which included four replicates (25 birds per replicate). Treatments consisted of unsupplemented basal diet (Control), basal diet containing 2% Pyr, basal diet containing 3% Cr and basal diet containing 5% Cr-Pyr. Cr-Pyr and Pyr significantly decreased the hepatic triglyceride and serum total cholesterol concentration (P < 0.01). Cr-Pyr markedly increased the serum non-esterified fatty acid and high-density lipoprotein cholesterol concentrations (P < 0.05), whereas the expression of carnitine palmitoyl transferase I (P < 0.05) and peroxisome proliferators-activated receptor-α (P < 0.01) mRNA in the liver were both decidedly enhanced in the Cr-Pyr group. The relative leg muscle weight was higher in the Cr-Pyr group than in the control group, whereas the serum uric acid content and hepatic glutamic-oxaloacetic transaminase activity were lower in the Cr-Pyr and Cr groups (P < 0.05), respectively. Muscle insulin-like growth factor I (P < 0.05) expression was enhanced, and the myostatin (P < 0.01) mRNA level was reduced in both the Cr-Pyr and Cr groups. In addition, Cr-Pyr did not alter body weight or the feed conversion ratio. These results indicate that, compared with Pyr and Cr alone, Cr-Pyr has a bifunctional role in broiler chickens, in that it influences both lipid and protein metabolism.

Keywords

creatine pyruvatepyruvatecreatinelipolysisprotein synthesis
Type
Full Paper
Information
animal , Volume 5 , Issue 7 , 31 May 2011 , pp. 1082 - 1089
Copyright
Copyright © The Animal Consortium 2011

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