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Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to 4 years

Published online by Cambridge University Press:  08 March 2007

Kirsi Laitinen*
Affiliation:
Department of Paediatrics, Turku University Central Hospital, Turku, Finland Department of Biochemistry and Food Chemistry and Functional Foods Forum, University of Turku, Itäinen Pitkäkatu 4A, 5th Floor, 20520 Turku, Finland
Marko Kalliomäki
Affiliation:
Department of Paediatrics, Turku University Central Hospital, Turku, Finland
Tuija Poussa
Affiliation:
Stat-Consulting, Tampere, Finland
Hanna Lagström
Affiliation:
The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Erika Isolauri
Affiliation:
Department of Paediatrics, Turku University Central Hospital, Turku, Finland Department of Paediatrics, University of Turku, Turku, Finland
*
*Corresponding author: Dr Kirsi Laitinen, fax +358 2 333 6862, email kirsi.laitinen@utu.fi
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Abstract

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Current research into dietary factors contributing to the development of allergic diseases is directed towards new active approaches instead of passive elimination diets. The present study aimed to investigate the explanatory role of the diet in a probiotic intervention study on the appearance of atopic eczema (AE) in childhood and the safety of perinatal supplementation with probiotics (Lactobacillus rhamnosus strain GG; ATCC 53 103). A prospective follow-up study from birth to 48 months of children (n 159) with a family history of allergic disease was carried out. Outcome measures included growth, dietary intake assessed with 4 d food diaries and their association with AE by logistic regression models. Increased intakes of retinol, Ca and Zn, with perinatal administration of probiotics, reduced the risk of AE, whilst an increase in intake of ascorbic acid increased the likelihood of AE. Perinatal administration of probiotics was safe, as it did not influence the height (mean difference 0·04 (95 % CI −0·33, 0·40) sd scores, P=0·852) or the weight-for-height (mean difference −3·35 (95 % CI −7·07, 0·37)%, P=0·077) of the children at 48 months with and without perinatal administration of probiotics. Up to 48 months, AE did not affect height (mean difference −0·05 (95 % CI −0·42, 0·33) sd scores, P=0·815), but mean weight-for-height in children with AE was −5·1 % (95 % CI −8·9, −1·2 %) lower compared with children without (P=0·010). The joint effects of nutrients and probiotics need to be considered in active prevention and management schemes for allergic diseases.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2005

References

Aberg, N, Hesselmar, B, Aberg, B & Eriksson, B (1995) Increase of asthma, allergic rhinitis and eczema in Swedish schoolchildren between 1979 and 1991. Clin Exp Allergy 25, 815819.CrossRefGoogle ScholarPubMed
Agostoni, C, Grandi, F, Scaglioni, S, Gianni, ML, Torcoletti, M, Radaelli, G, Fiocchi, A & Riva, E (2000) Growth pattern of breastfed and nonbreastfed infants with atopic dermatitis in the first year of life. Pediatrics 106, e73.CrossRefGoogle ScholarPubMed
Albers, R, Bol, M, Bleumink, R, Willems, AA & Pieters, RHH (2003) Effects of supplementation with vitamins A, C, and E, selenium, and zinc on immune function in a murine sensitization model. Nutrition 19, 940946.CrossRefGoogle Scholar
Arora, P, Kumar, V & Batra, S (2002) Vitamin A status in children with asthma. Pediatr Allergy Immunol 13, 223226.CrossRefGoogle ScholarPubMed
Barker, DJP (1995) Fetal origins of coronary heart disease. BMJ 311, 171174.CrossRefGoogle ScholarPubMed
Bjelakovic, G, Nikolova, D, Simonetti, RG & Gluud, C (2004) Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 364, 12191228.CrossRefGoogle ScholarPubMed
Bodner, C, Godden, D, Brown, K, Little, J, Ross, S & Seaton, A on behalf of Aberdeen WHEASE Study Group (1999) Antioxidant intake and adult-onset wheeze: a case–control study. Eur Respir J 13, 2230.CrossRefGoogle ScholarPubMed
Brook, CGD (1971) Determination of body composition of children from skinfold measurements. Arch Dis Child 46, 182184.CrossRefGoogle ScholarPubMed
Chang, KC, Miklich, DR, Barwise, G, Chai, H & Miles-Lawrence, R (1982) Linear growth of chronic asthmatic children: the effects of the disease and various forms of steroid therapy. Clin Allergy 12, 369378.CrossRefGoogle ScholarPubMed
Christie, L, Hine, RJ, Parker, JG & Burks, W (2002) Food allergies in children affect nutrient intake and growth. J Am Diet Assoc 102, 16481651.CrossRefGoogle ScholarPubMed
Dunstan, JA, Mori, TA, Barden, A, Beilin, LJ, Taylor, AL, Holt, PG & Prescott, SL (2003) Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy. Clin Exp Allergy 33, 442448.CrossRefGoogle ScholarPubMed
Eggesbo, M, Botten, G & Stigum, H (2001) Restricted diets in children with reactions to milk and egg perceived by their parents. J Pediatr 139, 583587.CrossRefGoogle ScholarPubMed
Ferguson, AC, Murray, AB & Tze, WJ (1982) Short stature and delayed skeletal maturation in children with allergic disease. J Allergy Clin Immunol 69, 461466.CrossRefGoogle ScholarPubMed
Fiocchi, A, Bouygue, GR, Martelli, A, Terracciano, L & Sarratud, T (2004) Dietary treatment of childhood atopic eczema/dermatitis syndrome (AEDS). Allergy 59, Suppl., 7885.CrossRefGoogle Scholar
Hakala, P, Marniemi, J, Knuts, L-R, Kumpulainen, J, Tahvonen, R & Plaami, S (1996) Calculated vs analysed nutrient composition of weight reduction diets. Food Chem 57, 7175.CrossRefGoogle Scholar
Halevy, O & Sklan, D (1987) Inhibition of arachidonic acid oxidation by β-carotene, retinol, and α-tocopherol. Biochim Biophys Acta 918, 304307.CrossRefGoogle ScholarPubMed
Hanifin, JM (1991) Atopic dermatitis in infants and children. Pediatr Clin North Am 38, 763789.CrossRefGoogle ScholarPubMed
Harik-Khan, RI, Muller, DC & Wise, RA (2004) Serum vitamin levels and the risk of asthma in children. Am J Epidemiol 159, 351357.CrossRefGoogle ScholarPubMed
Harizi, H, Juzan, M, Pitard, V, Moreau, J-F & Gualde, N (2002) Cyclooxygenase-2-issued prostaglandin E 2 enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J Immunol 168, 22552263.CrossRefGoogle ScholarPubMed
Hijazi, N, Abalkhail, B & Seaton, A (2000) Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia. Thorax 55, 775779.CrossRefGoogle Scholar
Hoppu, U, Rinne, M, Salo-Väänänen, P, Lampi, A-M, Piironen, V & Isolauri, E (2005) Vitamin C in breast milk may reduce the risk of atopy in the infant. Eur J Clin Nutr 59, 123128.CrossRefGoogle ScholarPubMed
Isolauri, E, Sütas, Y, Salo, MK, Isosomppi, R & Kaila, M (1998) Elimination diet in cow's milk allergy: risk for impaired growth in young children. J Pediatr 132, 10041009.CrossRefGoogle ScholarPubMed
Kalliomäki, M, Salminen, S, Arvilommi, H, Kero, P, Koskinen, P & Isolauri, E (2001) Probiotics in primary prevention of atopic disease: a randomised, placebo-controlled trial. Lancet 357, 10761079.CrossRefGoogle ScholarPubMed
Kalliomäki, M, Salminen, S, Poussa, T, Arvilommi, H & Isolauri, E (2003) Probiotics and prevention of atopic disease – a 4-year follow-up of a randomised placebo-controlled trial. Lancet 361, 18691871.CrossRefGoogle ScholarPubMed
Kankaanpää, PE, Salminen, S, Isolauri, E & Lee, YK (2001) The influence of polyunsaturated fatty acids on probiotic growth and adhesion. FEMS Microbiol Lett 194, 149153.CrossRefGoogle Scholar
Kardinaal, AFM, van't Veer, P, Brants, HAM, van den Berg, H, Van Schoonhoven, J & Hermus, RJJ (1995) Relations between antioxidant vitamins in adipose tissue, plasma, and diet. Am J Epidemiol 141, 440450.CrossRefGoogle ScholarPubMed
Kristmundsdottir, F & David, TJ (1987) Growth impairment in children with atopic eczema. J R Soc Med 80, 912.CrossRefGoogle ScholarPubMed
Lagström, H, Jokinen, E, Seppänen, R (1997) Nutrient intakes by young children in a prospective randomized trial of a low-saturated fat, low-cholesterol diet. The STRIP baby project. Arch Pediatr Adolesc Med 151, 181188.CrossRefGoogle Scholar
Massarano, AA, Hollis, S, Devlin, J & David, TJ (1993) Growth in atopic eczema. Arch Dis Child 68, 677679.CrossRefGoogle ScholarPubMed
Mathieu, C, Van Etten, E, Decallone, B, Guilietti, A, Gysemans, C, Bouillon, R & Overbergh, L (2004) Vitamin D and 1,25-dihydroxyvitamin D 3 as modulators in the immune system. J Steroid Biochem Mol Biol 89–90 449452.CrossRefGoogle ScholarPubMed
Miller, ER, Pastor-Barriuso, R, Dalal, D, Riemersma, RA, Appel, L & Guallar, E (2004) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 142, 3746.CrossRefGoogle ScholarPubMed
Milner, JD, Stein, DM, McCarter, R & Moon, RY (2004) Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma. Pediatrics 114, 2732.CrossRefGoogle ScholarPubMed
Nagel, G, Nieters, A, Becker, N & Linseisen, J (2003) The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults. Allergy 58, 12771284.CrossRefGoogle ScholarPubMed
Newberry, RD, Stenson, WF & Lorenz, RG (1999) Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen. Nat Med 5, 900906.CrossRefGoogle ScholarPubMed
Ninan, TK & Russell, G (1992) Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart. BMJ 304, 873875.CrossRefGoogle ScholarPubMed
Nordic Working Group on Diet and Nutrition (1996) Nordic Nutrition Recommendations. Scand J Nut 40, 161165.Google Scholar
Omata, N, Tsukahara, H, Ito, S et al. , (2001) Increased oxidative stress in childhood atopic dermatitis. Life Sci 69, 223228.CrossRefGoogle ScholarPubMed
Patel, L, Clayton, PE, Jenney, MEM, Ferguson, JE & David, TJ (1997) Adult height in patients with childhood onset atopic dermatitis. Arch Dis Child 76, 505508.CrossRefGoogle ScholarPubMed
Picado, C, Deulofeu, R, Lleonart, R, Agusti, M, Mullol, J, Quinto, L & Torra, M (2001) Dietary micronutrients/antioxidants and their relationship with bronchial asthma severity. Allergy 56, 4349.CrossRefGoogle ScholarPubMed
Powell, CVE, Nash, AA, Powers, HJ & Primhak, RA (1994) Antioxidant status in asthma. Pediatr Pulmonol 18, 3438.CrossRefGoogle ScholarPubMed
Rakoff-Nahoum, S, Paglino, J, Eslami-Varzaneh, F, Edberg, S & Medzhitov, R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229241.CrossRefGoogle ScholarPubMed
Räsänen, L, Ylönen, K (1992) Food consumption and nutrient intake of one- to two-year-old Finnish children. Acta Paediatr 81, 711.CrossRefGoogle ScholarPubMed
Rietjens, IMCM, Boersma, MG, de Haan, L, Spenkelink, B, Awad, HM, Cnubben, NHP, Van Zanden, JJ, van der Woude, H, Alink, GM & Koeman, JH (2002) The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids. Environ Toxicol Pharmacol 11, 321333.CrossRefGoogle ScholarPubMed
Rocklin, RE & Thistle, L (1986) Reduced prostaglandin E 2 (PGE 2 ) receptors on atopic T lymphocytes. Cell Immunol 99, 294299.CrossRefGoogle Scholar
Rocklin, RE, Thistle, L & Audera, C (1985) Decreased sensitivity of atopic mononuclear cells to prostaglandin E 2 (PGE 2 ) and prostaglandin D 2 (PGD 2 ). J Immunol 135, 20332039.CrossRefGoogle Scholar
Saavedra, JM, Abi-Hanna, A, Moore, N & Yolken, RH (2004) Long-term consumption of infant formulas containing live probiotic bacteria: tolerance and safety. Am J Clin Nutr 79, 261267.CrossRefGoogle ScholarPubMed
Shoseyov, D, Bibi, H, Biesalski, H & Reifen, R (2002) Repeated allergen challenge in rats increases vitamin A consumption. Chest 122, 14071411.Google Scholar
Siri, WE (1961) Body volume measurements by gas dilution. In Techniques for Measuring Body Composition, pp. 108117 [Brozek, J and Henschel, A, editors]. Washington, DC: National Academy of Sciences.Google Scholar
Sorva, R, Perheentupa, J & Tolppanen, EM (1984) A novel format for growth chart. Acta Paediatr 73, 527529.CrossRefGoogle ScholarPubMed
Soutar, A, Seaton, A & Brown, K (1997) Bronchial reactivity and dietary antioxidants. Thorax 52, 166170.CrossRefGoogle ScholarPubMed
Stephensen, CB (2001) Vitamin A, infection, and immune function. Annu Rev Nutr 21, 167192.CrossRefGoogle ScholarPubMed
Stone, WL, LeClair, I, Ponder, T, Baggs, G & Barret, Reis B (2003) Infants discriminate between natural and synthetic vitamin E. Am J Clin Nutr 77, 899906.Google Scholar
Tiainen, JM, Nuutinen, OM & Kalavainen, MP (1995) Diet and nutritional status in children with cow's milk allergy. Eur J Clin Nutr 49, 605612.Google ScholarPubMed
Ukabam, SO, Mann, RJ & Cooper, BT (1984) Small intestinal permeability to sugars in patients with atopic eczema. Br J Dermatol 110, 649652.CrossRefGoogle ScholarPubMed
Worm, M, Herz, U, Krah, JM, Renz, H & Henz, BM (2001) Effects of retinoids on in vitro and in vivo IgE production. Int Arch Allergy Immunol 124, 233236.CrossRefGoogle ScholarPubMed
Zeiger, RS & Heller, S (1995) The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. J Allergy Clin Immunol 95, 11791190.CrossRefGoogle Scholar