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Dietary ascorbic acid raises iron absorption in anaemic rats through enhancing mucosal iron uptake independent of iron solubility in the digesta

Published online by Cambridge University Press:  09 March 2007

K. J. H. Wienk ,
J. J. M. Marx ,
M. Santos ,
A. G. Lemmens ,
E. J. Brink ,
R. Van Der Meer  and
A. C. Beynen
K. J. H. Wienk
Affiliation:
Department of Laboratory Animal Science, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
J. J. M. Marx
Affiliation:
Eijkman-Winkler Institute and Department of Internal Medicine, University Hospital Utrecht, The Netherlands
M. Santos
Affiliation:
Eijkman-Winkler Institute and Department of Internal Medicine, University Hospital Utrecht, The Netherlands
A. G. Lemmens
Affiliation:
Department of Laboratory Animal Science, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
E. J. Brink
Affiliation:
Unilever Research Laboratorium, Vlaardingen, The Netherlands
R. Van Der Meer
Affiliation:
Netherlands Institute for Dairy Research, Ede, The Netherlands
A. C. Beynen
Affiliation:
Department of Laboratory Animal Science, Utrecht University, PO Box 80.166, 3508 TD Utrecht, The Netherlands
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Abstract

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We studied Fe absorption from FeSO4 in rats with Fe deficiency-induced anaemia that were given an Fe-sufficient purified diet without or with ascorbic acid (10·4 g/kg diet). Attention was focused on mucosal Fe uptake as measured in vivo by a double-isotope technique. Haemoglobin repletion and liver Fe levels were not affected when the ascorbic acid-supplemented diet was given, but apparent Fe absorption and retention of orally administered 59Fe were significantly enhanced. The distribution of Fe between liquid and solid phases of contents of both the stomach and the proximal intestine was not affected by the feeding of the ascorbic acid, but ascorbic acid significantly enhanced mucosal Fe uptake. It is concluded that ascorbic acid in the diet raises mucosal Fe uptake through a mechanism independent of the intestinal Fe solubility.

Keywords

Non-haem ironAscorbic acidAnaemia
Type
General Nutrition
Information
British Journal of Nutrition , Volume 77 , Issue 1 , January 1997 , pp. 123 - 131
Copyright
Copyright © The Nutrition Society 1997

References

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