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Changes in the modulation of retinocollicular transmission through group III mGluRs long after an increase in intraocular pressure in a rat model of glaucoma

Published online by Cambridge University Press:  30 May 2012

ANNE L. GEORGIOU ,
LI GUO ,
M. FRANCESCA CORDEIRO  and
THOMAS E. SALT
ANNE L. GEORGIOU*
Affiliation:
Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, UK Present address: Electrophysiology Department, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK
LI GUO
Affiliation:
Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, UK
M. FRANCESCA CORDEIRO
Affiliation:
Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, UK
THOMAS E. SALT
Affiliation:
Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, UK
*
†Address correspondence and reprint requests to: Anne L. Georgiou, Department of Visual Neuroscience, UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9EL, UK. E-mail: anne.georgiou@moorfields.nhs.uk
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Abstract

Metabotropic glutamate receptors (mGluRs) have been shown to be involved in the modulation of retinocollicular neurotransmission. In glaucoma, retinal ganglion cells (RGCs) degenerate, which may have an implication on this transmission as the superior colliculus is their major central target in the much-used rodent models of the disease. We have investigated this using an in vitro slice preparation of the superior colliculus by eliciting field excitatory postsynaptic potentials (fEPSPs) through optic tract stimulation in a rat ocular hypertension model of glaucoma. Application of the group III mGluR agonist L-AP4 reduced the peak amplitude of the fEPSP in superior colliculus slices through presynaptic mechanisms as previously shown in our lab. At 3 and 16 weeks after surgery, there were no significant differences in the effect of L-AP4 on fEPSP peak amplitude in the superior colliculus slices receiving input from the glaucomatous eyes [elevated intraocular pressure (IOP)] compared to those with input from the unoperated eyes (normal IOP). However, at 32 weeks, the fEPSP peak amplitude was reduced to a significantly greater degree during L-AP4 application in the elevated IOP slices compared to normal IOP slices. At all time points, there were no significant changes in the baseline amplitudes of fEPSPs or the stimulus intensities required to evoke fEPSPs. These results suggest that the modulation of synaptic transmission through group III mGluRs on RGC terminals to the superior colliculus is changed at later stages due to RGC degeneration through IOP elevation. These changes may be compensatory changes possibly through plasticity in the RGC terminals of surviving cells, which may be due to increases in the numbers of group III mGluRs. This result may have implications on further treatment studies carried out using these models of glaucoma as changes in the central visual system may need to be considered along with the retinal changes that occur.

Keywords

Superior colliculusRodent visual systemRetinal ganglion cellMetabotropic glutamate receptorsSynaptic transmission
Type
Research Articles
Information
Visual Neuroscience , Volume 29 , Issue 4-5 , September 2012 , pp. 237 - 246
Copyright
Copyright © Cambridge University Press 2012

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