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Intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill child with dilated cardiomyopathy

Published online by Cambridge University Press:  27 October 2010

Aris Lacis
Affiliation:
Latvian Centre of Pediatric Cardiology, Children’s Hospital, Riga, Latvia
Andrejs Erglis*
Affiliation:
Latvian Centre of Cardiology, Paula Stradina Clinical University Hospital, Riga, Latvia
*
Correspondence to: Prof. A. Erglis, MD, PhD, Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Pilsonu 13, LV-1002, Riga, Latvia. Tel: +371 67069379; Fax: +371 67069548; E-mail: a.a.erglis@stradini.lv

Abstract

Almost half of the children with symptomatic dilated cardiomyopathy receive a transplant or die within 2 years; however, cardiac stem cell transplantation has become a promising therapeutic option. The present case demonstrates for the first time, to our knowledge, the intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill 4-month-old child with severe dilated cardiomyopathy. Left ventricular ejection fraction increased from 20% before stem cell transplantation to 41% at 4 months of follow-up.

Type
Brief Reports
Copyright
Copyright © Cambridge University Press 2010

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References

1. Boucek, MM, Edwards, LB, Keck, BM, et al. The registry of the international society for heart and lung transplantation: fifth official pediatric report, 2001 to 2002. J Heart Lung Transplant 2002; 21: 827840.CrossRefGoogle ScholarPubMed
2. Matitiau, A, Perez-Atayde, A, Sanders, SP, et al. Infantile dilated cardiomyopathy: relation to outcome to left ventricular mechanics, hemodynamics, and histology at the time of presentation. Circulation 1994; 90: 13101318.Google Scholar
3. Taliercio, CP, Seward, JB, Driscoll, DJ, Fischer, LD, Gersh, BJ, Tajik, AJ. Idiopathic dilated cardiomyopathy in the young: clinical profile and natural history. J Am Coll Cradiol 1985; 6: 11261131.Google Scholar
4. Assmus, B, Honold, J, Schachinger, V, et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006; 335: 12221232.Google Scholar
5. Schachinger, V, Erbs, S, Elsasserv, A, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006; 355: 12101221.Google Scholar
6. Rupp, S, Bauer, J, Tonn, T, et al. Intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with dilated cardiomyopathy. Pediatr Transplant 2009; 13: 620623.CrossRefGoogle Scholar
7. Perin, EC, Dohmann, HF, Borojevic, R, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003; 107: 22942302.Google Scholar
8. Lange, R, Vogt, M, Horer, J, et al. Long-term results of repair of anomalous origin of the left coronary artery from the pulmonary artery. Ann Thorac Surg 2007; 83: 14631471.Google Scholar