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Comparative efficacy of standard antihookworm drugs against various test nematodes

Published online by Cambridge University Press:  05 June 2009

Anuradha Misra ,
P. K. S. Visen  and
J. C. Katiyar
Anuradha Misra
Affiliation:
Division of Parasitology, Central Drug Research Institute, Lucknow-226001, India
P. K. S. Visen
Affiliation:
Division of Parasitology, Central Drug Research Institute, Lucknow-226001, India
J. C. Katiyar
Affiliation:
Division of Parasitology, Central Drug Research Institute, Lucknow-226001, India
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Abstract

The chemotherapeutic responses of three test nematodes, Nippostrongylus brasilietxsis, Nematospiroidesdubius and Ancylostoma ceylanicum to standard antihookworm drugs were assessed in order to select asuitable host-parasite system for the primary screening of potential antihookworm compounds. N. dubiusbehaved inconsistently and, with some infections, required more drug to achieve 100% clearance. Nippostrongylus brasiliensis was found to be sensitive to thiabendazole, tetramisole and levamisole but the broad spectrum anthclmintic mebendazole was ineffective. A. ceylanicum was very sensitive to mebendazole, sensitive to tetramisole and levamisole and refractory to thiabendazole. In vitro, none of the compounds had any lethal effect against any of the nematodes, except mebendazole against A. ceylanicum.

A. ceylanicum does occur in man and its chemotherapeutic reactions are similar to those of target hookworm infections of economic importance. As such, although not equally sensitive to standard anthelmintics, it is recommended for routine primary screening.

Type
Research Article
Information
Journal of Helminthology , Volume 55 , Issue 4 , December 1981 , pp. 273 - 278
Copyright
Copyright © Cambridge University Press 1981

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