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Hippocampal/amygdala volumes in geriatric depression

Published online by Cambridge University Press:  01 May 1999

M. ASHTARI
Affiliation:
Division of Geriatric Psychiatry and the Brain Morphometry and Image Analysis Center, Hillside Hospital, Psychiatric Division and Department of Radiology, Long Island Jewish Medical Center, Glen Oaks and the Albert Einstein College of Medicine, Bronx, New York, USA
B. S. GREENWALD
Affiliation:
Division of Geriatric Psychiatry and the Brain Morphometry and Image Analysis Center, Hillside Hospital, Psychiatric Division and Department of Radiology, Long Island Jewish Medical Center, Glen Oaks and the Albert Einstein College of Medicine, Bronx, New York, USA
E. KRAMER-GINSBERG
Affiliation:
Division of Geriatric Psychiatry and the Brain Morphometry and Image Analysis Center, Hillside Hospital, Psychiatric Division and Department of Radiology, Long Island Jewish Medical Center, Glen Oaks and the Albert Einstein College of Medicine, Bronx, New York, USA
J. HU
Affiliation:
Division of Geriatric Psychiatry and the Brain Morphometry and Image Analysis Center, Hillside Hospital, Psychiatric Division and Department of Radiology, Long Island Jewish Medical Center, Glen Oaks and the Albert Einstein College of Medicine, Bronx, New York, USA
H. WU
Affiliation:
Division of Geriatric Psychiatry and the Brain Morphometry and Image Analysis Center, Hillside Hospital, Psychiatric Division and Department of Radiology, Long Island Jewish Medical Center, Glen Oaks and the Albert Einstein College of Medicine, Bronx, New York, USA
M. PATEL
Affiliation:
Division of Geriatric Psychiatry and the Brain Morphometry and Image Analysis Center, Hillside Hospital, Psychiatric Division and Department of Radiology, Long Island Jewish Medical Center, Glen Oaks and the Albert Einstein College of Medicine, Bronx, New York, USA
P. AUPPERLE
Affiliation:
Division of Geriatric Psychiatry and the Brain Morphometry and Image Analysis Center, Hillside Hospital, Psychiatric Division and Department of Radiology, Long Island Jewish Medical Center, Glen Oaks and the Albert Einstein College of Medicine, Bronx, New York, USA
S. POLLACK
Affiliation:
Division of Geriatric Psychiatry and the Brain Morphometry and Image Analysis Center, Hillside Hospital, Psychiatric Division and Department of Radiology, Long Island Jewish Medical Center, Glen Oaks and the Albert Einstein College of Medicine, Bronx, New York, USA

Abstract

Background. The hippocampus, amygdala and related functional circuits have been implicated in the regulation of emotional expression and memory processes, which are affected in major depression. Several recent investigations have reported abnormalities in these structures in adult and elderly depressives.

Methods. Elderly DSM-III-R unipolar depressives (N=40) and normal controls (N=46) participated in a magnetic resonance imaging study (1.0T). Brain images were obtained in the coronal plane. Using established anatomical guidelines for structure delineation, volumetric measurements of left and right hippocampus and anterior hippocampus/amygdala complex were completed under blinded conditions using a semi-automated computer mensuration system, with patients and controls in random order.

Results. Medial temporal volumes did not significantly distinguish either elderly depressed and age-similar normal control subjects, or late onset and early onset depressed patients (ANCOVA). Major overlap of measured volumes existed between patient and control groups. In depressives, hippocampal volumes significantly correlated with age, and cognitive and depression ratings, but not with number of prior depressive episodes or age-at-onset of first depression.

Conclusions. Hippocampal volumes do not discriminate a typical clinical population of elderly depressed patients from age-similar normal control subjects. If hippocampal dysfunction contributes to a diagnosis of syndromal depression in the elderly, such dysfunction does not appear to be regularly reflected in structural abnormalities captured by volumetric measurement as conducted. On the other hand, relationships between hippocampal volumes and clinical phenomena in depressives, but not controls, suggest potentially meaningful interactions between hippocampal structure and the expression of major depression in the elderly.

Type
Research Article
Copyright
© 1999 Cambridge University Press

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