Hostname: page-component-8448b6f56d-tj2md Total loading time: 0 Render date: 2024-04-17T06:55:41.268Z Has data issue: false hasContentIssue false

Adult cystic hygroma: successful use of OK-432 (Picibanil®)

Published online by Cambridge University Press:  23 April 2008

S L Woolley*
Affiliation:
Emergency Department, Bristol Royal Infirmary, University Hospital of Wales, Cardiff, Wales, UK
D R K Smith
Affiliation:
Otolaryngology Department, University Hospital of Wales, Cardiff, Wales, UK
S Quine
Affiliation:
Otolaryngology Department, University Hospital of Wales, Cardiff, Wales, UK
*
Address for correspondence: Dr Sarah L Woolley, Consultant, Emergency Department, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8BJ, UK. Fax: +44 117 928 2713 E-mail: sarah.woolley@ubht.nhs.uk

Abstract

Objective:

We report an adult case of cystic lymphangioma treated with OK-432 (Picibanil®).

Method:

A case report and review of the literature concerning the use of OK-432 to treat cystic lymphangioma is presented.

Results:

A 31-year-old woman developed a cystic lymphangioma four weeks post-partum. This was treated initially by aspiration, for diagnostic purposes. Investigation suggested that surgery would be challenging. A review of the literature demonstrated success with OK-432 in the treatment of this condition, although primarily in the paediatric population. This patient was successfully treated thus, and at the time of writing remained symptom free. A suggested management plan is outlined.

Conclusion:

Treatment with OK-432 is useful in the management of cystic lymphangiomas in adults and should be considered as first line treatment.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Orvidas, LT, Kasperbauer, JL. Pediatric lymphangiomas of the head and neck. Ann Otol Rhinol Laryngol 2000;109:411–21CrossRefGoogle ScholarPubMed
2 Sherman, BE, Kendall, KE. A unique case of the rapid onset of a large cystic hygroma in the adult. Am J Otolaryngol 2001;22:206–10CrossRefGoogle ScholarPubMed
3 Ogita, S, Tsuto, T, Tokiwa, K, Takahashi, T. Intracystic injection of OK-432: a new sclerosing therapy for cystic hygroma in children. Br J Surg 1987;74:690–1CrossRefGoogle ScholarPubMed
4 Ogita, S, Tsuto, T, Deguchi, E, Tokiwa, K, Nagashima, M, Iwai, N. OK-432 therapy for unresectable lymphangiomas in children. J Ped Surg 1991;26:263–70CrossRefGoogle ScholarPubMed
5 Ogita, S, Tsuto, T, Nakamura, K, Deguchi, E, Iwai, N. OK-432 therapy in 64 patients with lymphangiomas. J Ped Surg 1994;29:784–5CrossRefGoogle Scholar
6 Greinwald, JH Jr, Burke, DK, Sato, Y, Poust, RI, Kimura, K, Bauman, NM et al. Treatment of lymphangiomas in children: an update of Picibanil (OK-432) sclerotherapy. Otolaryngol Head Neck Surg 1999;121:381–7CrossRefGoogle ScholarPubMed
7 Smith, R, Burke, D, Sato, Y, Poust, RI, Kimura, K, Bauman, NM. OK-432 therapy for lymphangiomas. Arch Otolaryngol Head Neck Surg 1996;122:1195–9CrossRefGoogle ScholarPubMed
8 Giguere, CM, Bauman, N, Smith, RJH. New treatment options for lymphangioma in infants and children. Ann Otol Rhinol Laryngol 2002;111:1066–75CrossRefGoogle ScholarPubMed
9 Alonso, J, Barbier, L, Alvarez, J, Romo, L, Martin, JC, Artteagoitia, I et al. OK432 (Picibanil) efficacy in an adult with cystic cervical lymphangioma. A case report. Oral Surg Oral Med Oral Pathol 2005;10:362–6Google Scholar
10 Sichel, JY, Udassin, R, Gozal, D, Koplewitz, BZ, Dano, I, Eliashar, R. OK-432 Therapy for cervical lymphangioma. Laryngoscope 2004;114:1805–9CrossRefGoogle ScholarPubMed
11 Landing, BH, Farber, S. Tumors of the cardiovascular system. In: Atlas of Tumor Pathology. Washington DC: Armed Forces Institute of Pathology, 1956Google Scholar
12 Mulliken, JB, Young, AE. Lymphatic malformations. In: Mulliken, John B. Vascular Birthmarks, Hemangiomas and Malformations. Philadelphia: Saunders, 1988Google Scholar
13 Schefter, RP, Olsen, KD, Gaffey, TA. Cervical lymphangioma in the adult. Otolaryngol Head Neck Surg 1985;93:65–9CrossRefGoogle ScholarPubMed
14 El-Silimy, O, Corney, C. The value of sonography in the management of cystic neck lesions. J Laryngol Otol 1993;107:245–51CrossRefGoogle ScholarPubMed
15 Curran, AJ, Malik, N, McShane, D, Timon, CVI. Surgical management of lymphangiomas in adults. J Laryngol Otol 1996;110:586–9CrossRefGoogle ScholarPubMed
16 Ricciardelli, EJ, Richardson, MA. Cervicofacial cystic hygroma patterns of recurrence and management of the difficult case. Arch Otolaryngol Head Neck Surg 1991;117:546–53CrossRefGoogle ScholarPubMed
17 Martin, JA. Treatment of cystic hygroma. Texas Journal of Medicine 1954;50:217–22Google ScholarPubMed
18 Riechelmann, H, Muehlfay, G, Teck, T. Total, sub-total, and partial surgical removal of cervicofacial lymphangiomas. Arch Otolaryngol Head Neck Surg 1999;125:643–8CrossRefGoogle Scholar
19 Hancock, BJ, StVil, D, Di Lorenzo, M, Blanchard, H. Complications of lymphangiomas in children. Pediatr Surg 1992;27:220–6CrossRefGoogle ScholarPubMed
20 Farmaud, M, Kuttenberger, JJ. A new therapeutic concept for the treatment of cystic hygroma. Oral Surg Oral Med Oral Pathol 1996;81:389–95CrossRefGoogle Scholar
21 Stein, M, Hsu, RK, Schneider, PD, Ruebner, BH, Mina, Y. Alcohol ablation of a mesenteric lymphangioma. J Vasc Interv Radiol 2000;11:247–50CrossRefGoogle ScholarPubMed
22 Dubois, J, Garel, L, Abela, A, Laberge, L, Yazbeck, S. Lymphangiomas in children: percutaneous sclerotherapy with an alcoholic solution of Zein. Radiology 1997;204:651–4CrossRefGoogle ScholarPubMed
23 Yura, J. Bleomycin treatment for cystic hygroma in children. Arch Jpn Chir 1977;46:607–12Google ScholarPubMed
24 Turner, C, Gross, S. Treatment of recurrent suprahyoid cervicofacial lymphangioma with intravenous cyclophosphamide. Am J Pediatric Hematol Oncol 1994;16:325–8Google ScholarPubMed
25 Castanon, M, Margarit, J, Carrasco, R, Vancells, M, Albert, A, Morales, L. Long-term follow up of nineteen cystic lymphangiomas treated with fibrin sealant. J Pediatr Surg 1999;34:1276–9CrossRefGoogle ScholarPubMed
26 Reinhardt, MA, Nelson, SC, Sencer, SF, Bostrom, BC, Kurachek, SC, Nesbit, ME. Treatment of childhood lymphangiomas with interferon-alpha. J Pediatr Hematol Oncol 1997;19:232–6CrossRefGoogle ScholarPubMed
27 Villavicencio, JL. Primum non nocere: is it always true? The use of absolute ethanol in the management of congenital vascular malformations. J Vasc Surg 2001;33:904–6CrossRefGoogle ScholarPubMed
28 Orford, J, Barker, A, Thonell, S, King, P, Murphy, J. Bleomycin therapy for cystic hygroma. J Ped Surg 1995;30:1282–7CrossRefGoogle ScholarPubMed
29 Tanaka, K, Inomata, Y, Utsunomiya, H, Uemoto, S, Asonuma, K, Katayama, T et al. Sclerosing therapy with bleomycin emulsion for lymphangioma in children. Pediatr Surg 1990;5:270–3Google Scholar
30 Gutierrez, San Roman, Barrios, J, Lluna, J, Menor, F, Poquet, J, Ruiz, S. Treatment of cervical lymphangioma using fibrin adhesive. Eur J Pediatr Surg 1993;3:356358Google Scholar
31 Ezekowitz, RA, Mulliken, JB, Folkman, I. Interferon alfa-2a therapy for life-threatening haemangiomas of infancy. NEJM 1992;326:1456–63CrossRefGoogle ScholarPubMed
32 Okamoto, H. Experimental anticancer studies. Part XXXI. On the streptococcal preparation having potent anticancer activity. Jpn J Exp Med 1966;36:175–86Google Scholar
33 Ishida, N, Hoshino, T. A streptococcal preparation as a potent biological response modifier OK-432, 2nd edn. Amsterdam: Excerpta Medica, 1983;2037Google Scholar
34 Giguere, CM, Bauman, N, Sato, Y, Burke, DK, Greinwald, JH, Pransky, S et al. Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial. Arch Otolaryngol Head Neck Surg 2002;128:1137–44CrossRefGoogle ScholarPubMed
35 Schmidt, B, Schimpl, C, Hollwarth, ME. OK-432 therapy of lymphangiomas in children. Eur J Pediatr 1996;153:649–52CrossRefGoogle Scholar
36 Luzzatto, C, Midrio, P, Tchaprassian, Z, Guglielmi, M. Sclerosing treatment of lymphangiomas with OK-432. Arch Dis Child 2000;82:130–4CrossRefGoogle ScholarPubMed
37 Sung, MW, Lee, DW, Kim, DY, Lee, SJ, Hwang, CH, Park, SW et al. Sclerotherapy with Picibanil (OK-432) for congenital lymphatic malformation in the head and neck. Laryngoscope 2001;111:1430–3CrossRefGoogle ScholarPubMed
38 Bresiw, C, Pracy, JP, Albert, DM. Treatment of lymphangiomas of the head and neck in children by intralesional injection of OK-432 (Picinabil). Clin Otolaryngol 2000;25:130–4Google Scholar
39 Laranne, J, Keski-Nisula, L, Rautio, R, Rautiainen, M, Airaksinen, M. OK-432 (Picibanil) therapy for lymphangiomas in children. Eur Arch Otorhinolaryngol 2002;259:274–8CrossRefGoogle ScholarPubMed