Hostname: page-component-8448b6f56d-jr42d Total loading time: 0 Render date: 2024-04-18T22:31:44.542Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetic studies on male sterility of hybrids between laboratory and wild mice (Mus musculus L.)

Published online by Cambridge University Press:  14 April 2009

J. Forejt  and
P. Iványi
J. Forejt
Affiliation:
Institute of Experimental Biology and Genetics, Czechoslovak Academy of Sciences, 142 20 Praha 4, Krč, Czechoslovakia
P. Iványi
Affiliation:
Institute of Experimental Biology and Genetics, Czechoslovak Academy of Sciences, 142 20 Praha 4, Krč, Czechoslovakia
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The genetic control of the sterility of male hybrids between certain laboratory and wild mice (Mus musculus L.) is investigated. The observed sterility is, by definition, hybrid sterility since both parental forms (i.e. wild and laboratory mice) are fully fertile, their male offspring displaying small testes with arrest of spermatogenesis at the stage of spermatogenesis or primary spermatocytes. Results of genetic analysis as well as the failure to detect any chromosomal rearrangements point to a genie rather than a chromosomal type of hybrid sterility.

Fifty-three wild males were classified into three sets, after mating with C57BL/10 inbred females, according to the fertility of their male progeny (set I – only sterile sons; set II – only fertile sons; set III – both fertile and sterile sons). The wild males of set I, which yield only sterile male offspring with C57BL/10 females, sire sterile sons also with females of the following inbred strains: A/Ph, BALB/c, DBA/1, and AKR/J, whereas the same wild males produce fertile offspring with females of C3H/Di, CBA/J, P/J, I/St and F/St inbred strains.

The described hybrid sterility seems to be under the control of several independently segregating genes, one of them (proposed symbol Hst-1) being localized on chromosome 17 (linkage group IX), 6 cM distally from dominant T (Brachyury). A chance to search for the mechanism of hybrid sterility is provided by the finding of two laboratory inbred strains, C57BL/10 and C3H/Di, differing with respect to the Hybrid sterility genetic system only at the Hst-1 gene.

Hst-1 is closely linked but apparently not identical with the sterility factor of recessive t alleles of the T locus.

Type
Research Article
Information
Genetics Research , Volume 24 , Issue 2 , October 1974 , pp. 189 - 206
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Bennett, D. (1964). Abnormalities associated with, a chromosome region in the mouse. II. Embryological effects of lethal alleles in the t-region. Science 144, 263–267.Google ScholarPubMed
Bennett, D. & Dunn, L. C. (1967). Studies of the effect of t-alleles in the house mouse on spermatozoa. I. Male sterility effects. Journal of Reproduction and Fertility 13, 421–428.CrossRefGoogle ScholarPubMed
Bennett, D. & Dunn, L. C. (1971). Transmission ratio distorting genes on chromosome IX and their interactions. In Immunogenetics of H-2 System (ed. Lengerová, A. and Vojtíšková, M.), pp. 90–103. Basel: Karger.Google Scholar
Burkholder, G. D. & Comings, D. E. (1972). Do the Giemsa-banding patterns of chromosomes change during embryonic development? Experimental Cell Research 75, 268–271.CrossRefGoogle ScholarPubMed
Cattanach, B. M. & Moseley, H. (1973). Nondisjunction and reduced fertility caused by the tobacco mouse metacentric chromosomes. Cytogenetics and Cell Genetics 12, 264–287.CrossRefGoogle Scholar
Dobzhansky, T. (1951). Genetics and the Origin of Species, 3rd ed.New York: Columbia University.Google Scholar
Dobzhansky, T. (1972). Species of Drosophila. Science 177, 664–669.CrossRefGoogle ScholarPubMed
Dunn, L. C. (1956). Analysis of a complex gene in the house mouse. Cold Spring Harbor Symposia on Quantitative Biology 21, 187–195.CrossRefGoogle ScholarPubMed
Dunn, L. C. (1964). Abnormalities associated with a chromosome region in the mouse. I. Transmission and population genetics of the t-region. Science 144, 260–263.CrossRefGoogle ScholarPubMed
Dunn, L. C., Bennett, D. & Beasley, A. B. (1962). Mutation and recombination in the vicinity of a complex gene. Genetics 47, 285–303.CrossRefGoogle ScholarPubMed
Dunn, L. C. & Bennett, D. (1971). Lethal alleles near locus T in house mouse populations on the Jutland Peninsula, Denmark. Evolution 25, 451–453.CrossRefGoogle Scholar
Dunn, L. C. & Caspari, E. (1945). A case of neighboring loci with similar effects. Genetics 30, 543–568.CrossRefGoogle ScholarPubMed
Forejt, J. (1972 a). Giemsa-specific centromeric heterochromatin in three inbred mouse strains. Folia biologica 18, 213–215.Google ScholarPubMed
Forejt, J. (1972 b). Chiasmata and crossing-over in the male mouse (Mus musculus). Suppression of recombination and chiasma frequencies in the ninth linkage group. Folia biologica 18, 161–170.Google ScholarPubMed
Forejt, J. (1973). Centromeric heterochromatin polymorphism in the house mouse. Evidence from inbred strains and natural populations. Chromosoma 43, 187–201.CrossRefGoogle ScholarPubMed
Gropp, A., Winking, H., Zech, L. & Muller, H. (1972). Robertsonian chromosomal variation and identification of metacentrio chromosomes in feral mice. Chromosoma 39, 265–288.CrossRefGoogle ScholarPubMed
Haldane, J. B. S. (1922). Sex ratio and unisexual sterility in hybrid animals. Journal of Genetics 12, 101–109.CrossRefGoogle Scholar
Hampl, R., Iványi, P. & Stárka, L. (1971). Testosterone and testosterone binding in murine plasma. Steroidologia 2, 113–120.Google ScholarPubMed
Hunt, W. G. & Selander, R. K. (1973). Biochemical genetics of hybridization in European house mouse. Heredity 31, 11–33.CrossRefGoogle Scholar
Iványi, P., Hampl, R., Stárka, L. & Micková, M. (1972). Genetic association between H-2 gene testosterone metabolism in mice. Nature, New Biology 238, 280–281.CrossRefGoogle ScholarPubMed
Iványi, P. & Micková, M. (1971). Further studies on genetic factors in the ninth linkage group influencing reproductive performance in male mice. In Immunogenetics of H-2 System (ed. Lengerová, A. and Vojtíšková, M.), pp. 104–119. Basel: Karger.Google Scholar
Iványi, P., VojtíškovÁ, M., Démant, P. & Micková, M. (1969). Genetic factors in the ninth linkage group influencing reproductive performance in male mice. Folia biologica 15, 401–421.Google ScholarPubMed
Johnston, P. G. (1968). Male sterility in mice homozygous for the tw2 allele. Australian Journal of Biological Sciences 21, 947–951.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Meredith, R. (1964 a). Investigations of the nature of t-alleles in the mouse. I. Genetic analysis of a series of mutants derived from a lethal allele. Heredity 19, 301–312.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Meredith, R. (1964 b). Investigations of the nature of t-alleles in the mouse. II. Genetic analysis of an unusual mutant allele and its derivatives. Heredity 19, 313–325.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Meredith, R. (1964 C). Investigations of the nature of t-alleles in the mouse. III. Short tests of some further mutant alleles. Heredity 19, 327–330.CrossRefGoogle ScholarPubMed
Lyon, M. F. & Phillips, R. J. S. (1959). Crossing-over in mice heterozygous for t alleles. Heredity 13, 23–32.CrossRefGoogle Scholar
Mayr, E. (1963). Animal Species and Evolution. Cambridge: Harvard University PressCrossRefGoogle Scholar
Micková, M. & Iványi, P. (1971). Histocompatibility antigens in the wild house mouse. In Immunogeneties of H-2 System (ed. Lengerová, A. and Vojtíšková, M.), pp. 20–34. Basel: Karger.Google Scholar
Seabright, M. (1972). The use of proteolytic enzymes for the mapping of structural rearrangements in the chromosomes of man. Chromosoma 36, 204–210.CrossRefGoogle ScholarPubMed
Selander, R. K., Hunt, W. G. & Yang, S. H. (1969). Protein polymorphism and genic heterozygosity in two European subspecies of the house mouse. Evolution 23, 379–390.CrossRefGoogle Scholar
Staats, J. (1966). The laboratory mouse. In Biology of the Laboratory Mouse (ed. Green, E. L.), pp. 1–11. New York: McGraw-Hill.Google Scholar
Steinberger, E. (1971). Hormonal control of mammalian spermatogenesis. Physiological Review 51, 1–22.CrossRefGoogle ScholarPubMed
Stimpfling, J. H. (1961). The use of PVP as developing agent in mouse hemagglutination test. Transplantation Bulletin 27, 109–110.CrossRefGoogle Scholar
Wallace, B. (1959). The influence of genetic systems on geographical distribution. Cold Spring Harbor Symposia on Quantitative Biology 24, 193–204.CrossRefGoogle ScholarPubMed
Wolfe, G. H. (1971). Genetic influence on gonadotropic activity in mice. Biology of Reproduction 4, 161–173.CrossRefGoogle ScholarPubMed