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Further Experiments on the Action of Emetine in Cultures of Entamoeba histolytica

Published online by Cambridge University Press:  06 April 2009

P. P. Laidlaw
Affiliation:
National Institute for Medical Research, London, N.W.3.
Clifford Dobell
Affiliation:
National Institute for Medical Research, London, N.W.3.
Ann Bishop
Affiliation:
National Institute for Medical Research, London, N.W.3.

Extract

In 1926 two of us published the results of a long series of experiments on the toxic action of the alkaloids of ipecacuanha in cultures of several species of entozoic amoebae. These experiments led us to definite conclusions regarding the differential susceptibility of the various species of amoebae studied, and the relative potency of several alkaloids employed. They also showed clearly that the full specific action of emetine, on susceptible amoebae, is only disclosed if the alkaloid is allowed to act for a sufficient time (two or three days.)

Type
Research Article
Copyright
Copyright © Cambridge University Press 1928

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References

Barret, H. P. and Smith, N. M. (1924). The cultivation of an Endamoeba from the turtle, Chelydra serpentina. Amer. J. Hyg. 4, 155.Google Scholar
Boeck, W. C. and Drbohlav, J. (1925). The cultivation of Endamoeba histolytica. Amer. J. Hyg. 5, 371.Google Scholar
Dobell, C. and Laidlaw, P. P. (1920). The action of ipecacuanha alkaloids on Entamoeba histolytica and some other entozoic amoebae in culture. Parasitol. 18, 206.Google Scholar
Dobell, C. and Laidlaw, P. P. (1926 a). On the cultivation of Entamoeba histolytica and some other entozoic amoebae. Parasitol. 18, 283.Google Scholar
Gros, O. (1910). Ueber die Narkotika und Localanaesthetika. II. Mitteilung. Arch. exp. Path. u. Pharm. 63, 80.Google Scholar
Gros, O. (1912). Idem. III. Mitteilung. Arch. exp. Path. u. Pharm. 67, 126.Google Scholar
Kofoid, C. A. and Wagener, E. H. (1925). Studies on the effects of certain drugs upon Endamoeba dysenteriae in vitro. Univ. California Publ. Zool. 28, 155.Google Scholar
Sautet, J. (1927). Recherches expérimentales sur quelques produits employés dans le traitement de la dysenteric amibienne. Ann. Parasitol. 5, 329.Google Scholar
Trevan, J. W. and Boock, E. (1927). The relation of hydrogen-ion concentration to the action of the local anaesthetics. Brit. J. Exp. Path. 8, 307.Google Scholar
Vogel, H. (1927). Über Kulturen der Ruhramobe und deren Beeinflussung durch Yatren. Arch.f. Schiffs- u. Trop.-Hyg. 31, 74.Google Scholar