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The neuropsychological profiles of mild Alzheimer's disease and questionable dementia as compared to age-related cognitive decline

Published online by Cambridge University Press:  01 July 2003

ELISE CACCAPPOLO-VAN VLIET
Affiliation:
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York
JENNIFER MANLY
Affiliation:
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York
MING-XIN TANG
Affiliation:
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York Division of Biostatistics, Columbia University College of Physicians and Surgeons, New York, New York
KAREN MARDER
Affiliation:
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York
KAREN BELL
Affiliation:
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York
YAAKOV STERN
Affiliation:
Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York

Abstract

Test scores from a comprehensive neuropsychological battery administered to 1602 subjects consisting of 1347 subjects with probable Alzheimer's disease (AD), 100 subjects with questionable dementia (QD) and 155 non-demented elderly control subjects were cross-sectionally analyzed. Subjects with probable AD were categorized as mild (n = 244), moderate (n = 480), severe (n = 376), and very severe (n = 247) according to modified mini mental status exam (mMMSE) scores. Mean scores on individual neuropsychological tests are provided for each group of subjects. Stratified random sampling was performed to select a sample of mild AD subjects who were matched in age and education to non-demented elderly controls, and analyses focused on the performance of QD subjects and mild AD subjects, whose scores were compared to those of the elderly control subjects. Selected scores were organized by cognitive domain and logistic regressions were used to determine the domains and individual tests within each that were most predictive of group status. Results suggested a profile of scores associated with QD and mild AD including impaired recall of verbal information for both groups. Areas of lower functioning in QD subjects as compared to elderly controls included category fluency and visuospatial ability. (JINS, 2003, 9, 720–732.)

Type
Research Article
Copyright
© 2003 The International Neuropsychological Society

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