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Biosensing using photonic crystal nanolasers

Published online by Cambridge University Press:  25 November 2015

Toshihiko Baba
Toshihiko Baba*
Affiliation:
Department of Electrical and Computer Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogayaku, Yokohama 240-8501, Japan
*
Address all correspondence to Toshihiko Baba atbaba@ynu.ac.jp
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Abstract

Photonic crystal nanolasers are fabricated and operated simply, and can be applied as disposable sensors for biomedical applications. They are sensitive to the change with environmental index and surface charge. Functionalizing the nanolaser surface with an antibody, the specific binding of target antigen is detected with a detection limit 2–4 orders lower than that achieved by current standard methods, enzyme-linked immuno-sorbent assay. Nanolasers also detect negatively-charged deoxyribonucleic acid from their emission intensity. This technique requires neither labels nor spectroscopy, which simplifies screening procedures. Its applicability for high-speed detection of endotoxin and for label-fee imaging of living cells are also demonstrated.

Type
Plasmonics, Photonics, and Metamaterials Prospective Article
Information
MRS Communications , Volume 5 , Issue 4 , December 2015 , pp. 555 - 564
Copyright
Copyright © Materials Research Society 2015 

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