A detailed and critical discussion of John Home, a certified inmate of the Royal Edinburgh Asylum during 1886–87, is presented from a historical perspective which is sensitive to the respective positions of the practitioner and the patient. Particular attention is paid to the letters Home wrote during his confinement and their significance for understanding asylum life during this period. Some interpretative difficulties surrounding the use of medical records, patient letters and other related evidence are also examined.

Until his retirement in 1959 Ernst Kretschmer was Professor of Psychiatry at the University of Tübingen. He published eight monographs, five of which were of eminent importance and at least two exerted considerable influence on European psychiatry for several decades, namely Der sensitive Beziehungswahn (1918) and Körperbau und Charakter (1921). His theory on constitutional body types and character became an integral part of German schoolbooks.

It is common knowledge that puberty is characterized, among other phenomena, by a striking growth spurt. An exploration of the medical literature from previous centuries shows, however, that this feature of adolescence has attracted surprisingly little attention. Although the pubertal growth spurt was known to eighteenth-century physicians, it was neglected for about a century. The influential Belgian scientist Quetelet demonstrated a remarkable scotoma towards the phenomenon. It was only after his death in 1874 that the relationship between puberty and growth spurt became a scientifically established and recognized fact.

In the past some workers have reported positive relationships between indices of noradrenaline activity and measures of hypothalamic–pituitary–adrenal (HPA)-axis function. In order to investigate these relations, the authors measured noradrenaline, adrenaline and vanillylmandelic acid (VMA) in 24 h urine samples of 72 depressed females. Serum adrenocorticotrophic hormone (ACTH) and cortisol concentrations were determined before and after administration of 1 mg of dexamethasone. Cortisol non-suppressors exhibited a significantly higher noradrenaline, adrenaline and VMA excretion as compared to cortisol suppressors. We determined significantly positive correlations between the postdexamethasone cortisol values and the excretion rates of noradrenaline and VMA. These indices of noradrenaline activity correlated neither with the baseline cortisol and ACTH nor with the postdexamethasone ACTH values.

Plasma concentrations of oestrogen stimulated neurophysin (ESN) were reduced in 28 patients with Alzheimer's disease (AD) compared with 14 age-matched controls, 16 patients with other presenile dementias and 12 patients with major depressive disorder. The ESN response to oestrogen challenge was delayed in 10 AD patients compared with 7 age-matched controls. Reduced basal and oestrogen stimulated plasma ESN may be related to impaired responsiveness of the hypothalamo-neurohypophysial neurons and/or a reduction in the amount of pituitary ESN available for release. Plasma ESN measurements may be of value for excluding the diagnosis of AD in patients with dementia who present before the age of 65.

The neuropathological results from a prospective, systematically assessed, series of 56 schizophrenic patients and 56 age- and sex-matched normal controls have been presented.

When compared with the normal controls, the brains of the schizophrenic subjects showed a significant reduction in brain weight and brain length with a concomitant increase in ventricular size. (All findings relate to measurements made after formalin fixation). In addition, the brains of the schizophrenic patients contained significantly more non-specific focal pathology and fibrillary gliosis than the controls.

After exclusion of cases with moderate and severe Alzheimer-type change, cerebro-vascular disease and all forms of focal pathology, the structural brain changes (i.e. decrease in brain weight and brain length) continued to distinguish the schizophrenia group from the controls. Furthermore, an analysis of the clinical data showed that the structural brain changes were correlated in the schizophrenic patients with a measurement of pre-morbid function.

The findings and their possible aetiological implications have been discussed.

In one of his Cahiers, Paul Valéry has the note. Somatism (heresy of the end of time),

Adoration, cult of the machine for living.† Have we come to the end of time? The heresy anticipated by Valéry has almost become the official religion. Everything is related to the body, as if it had just been rediscovered after being long forgotten; body image, body language, body consciousness, liberation of the body are the passwords. Historians, prey to the same infection, have begun inquiring into what previous cultures have done with the body, in way of tattooing, mutilation, celebration all the rituals related to the various bodily functions.2 Past writers from Rabelais to Flaubert are ransacked for evidence, and immediately it becomes apparent that we are far from being the first discoverers of bodily reality. That reality was the first knowledge to enter human understanding: ‘They knew that they were naked’ (Genesis 3.7). From then on, it has impossible to ignore the body.