William Mayer-Gross was born in the ancient Rhineland town of Bingen. He attended the Gymnasium in Worms and studied medicine in Heidelberg, Kiel and Munich. He took his final medical examinations in Heidelberg in 1912. He then became an assistant in the Heidelberg Psychiatric Clinic and in 1913 presented his doctoral thesis, which dealt with the phenomenology of abnormal feelings of felicity. On the outbreak of the First World War he was called up and served for a year on the Western front; he was then in 1915 assigned to duties in a base hospital where neurotic soldiers were being cared for.

The published work relating to the effects of noise on man and animals is reviewed from the standpoint of mental health. Evidence from a number of different disciplines shows that the presence of meaning in the noise is of critical importance in determining the persistence of physical reactions to the noise. The existing evidence linking noise with mental illness is found to be unsatisfactory. The concept of annoyance and the relevance of noise annoyance to mental illness are discussed. Some specific suggestions for further work are put forward.

An ultrasonic system for measuring psychomotor behaviour is described, and then applied to compare the extent to which English and French students gesticulate.

The findings supported the hypotheses that: (1) French students gesticulate more than the English both when using descriptive speech and when discussing their feelings; (2) descriptive speech elicits more gesture then affectively-toned speech; (3) when verbal expression is more difficult the use of gesture increases; (4) individuals tend to maintain a characteristic level of gesturing.

We concluded the ultrasonic system provides a reliable and sensitive method for measuring gesture activity and can be applied clinically to the study of psychomotor behaviour.

Thirty married agoraphobic women referred to out-patient clinics in Edinburgh were compared with ‘normal’ controls (selected from GP records and screened for the absence of psychiatric symptoms) matched on age, sex, social class and marital status. The agoraphobics' husbands were similarly compared with the husbands of the controls. On most measures of attitudes, behaviour, domestic organization and marital interaction, the 2 groups were strikingly similar.

In a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured by the Hamilton Depression Scale, showed no significant relationships. The implications of the study are discussed.

The daily excretion of adenosine 3′5′ cyclic monophosphate (c-AMP) in a group of 19 patients with a severe depressive illness was found to be significantly decreased when compared with that from a group of euthymic patients being treated for other disorders in the same ward. The daily excretion of the depressed patients increased during the period of treatment and recovery from the illness. Treatment with a tricyclic antidepressant caused a greater increase than electroconvulsive treatment (ECT). There was no difference between the mean plasma c-AMP concentration of the depressed and euthymic groups. The mean CSF c-AMP concentration was not different from the mean plasma c-AMP concentration in 12 patients with severe depression. There was no direct correlation between the CSF and plasma concentrations within patients. It was concluded that there may be a reversible disturbance in the renal metabolism of c-AMP in patients with severe depression.

The review deals with the possibility of diffuse brain damage, not always clinically obvious, in chronic alcoholics. Some of its implications are discussed with special reference to the role of frontal lobe damage. The main areas of enquiry-neuropathological, neuroradiological and psychological – are considered in detail.

Two hundred and twenty long-stay psychiatric patients were surveyed by means of semi-standardized interviews and by obtaining information from nursing staff and case records. Each patient's needs for accommodation and employment were assessed as if immediate discharge from hospital were being contemplated. The results of the exercise emphasize the need for long-stay to permanent accommodation. The validity of this method of assessing community care requirements is discussed.

Various clinical and social measures were applied to forty long-stay schizophrenic patients before and after transfer from hospital to a residential home and similarly to twenty-five patients retained in hospital. The results are used to test specific hypotheses concerning the relationship between social changes and clinical state in chronic schizophrenia.

The present paper outlines the number and distribution of forensic patients within one region. In addition, attitudes to both available services and existing legislation are described. Regional and national data are compared so that the results can be used by other regions which are currently planning a development of their own forensic services.

Altered activities of biogenic amine-related enzymes have been reported in some studies of patients with affective disorders and chronic schizophrenia. To evaluate whether any relationship between personality variations, including non-diagnosed psychopathology, and these enzymes might occur in non-psychiatric patients, 95 young adult volunteers were studied. Higher MMPI and Zuckerman sensation-seeking scale scores were found in male, but not female, volunteers with lower platelet and plasma amine oxidase activities. Males generally exhibited negative correlations, while females had positive correlations between the psychological test scores and amine oxidase activities. In contrast to the amine oxidase results, no associations were observed between plasma dopamine β-hydroxylase activities and the personality variables.

Elevated blood serotonin, perhaps secondary to reduced platelet MAO, has been reported in a group of chronic schizophrenic patients. We have failed to find elevated platelet serotonin, or any relationship between platelet serotonin and MAO either in a group of unmedicated chronic schizophrenic patients or in a group of schizoaffective patients. Possible reasons for these discrepancies are discussed.

A survey of more than 6000 school children in 1961 established norms for symptomatology and behaviour at ages 5–15. A follow-up to 1968 identified all children from the survey attending a child guidance clinic or appearing in court within that time. Those thus identified contained a significantly high proportion of boys who were reported as having more than 3 deviant items (i.e. occurring in approximately 10% of subjects in 1961). Specific health and behavioural items were found to have been reported in 1961 in proportions which were significantly different for children later appearing in child guidance clinic from those appearing in court. The amount of concern expressed by their parents over psychological and behavioural items distinguished court from clinic boys, while the concern shown by parents over items of physical health showed little difference in these 2 groups.

The performance of 21 chronic schizophrenic patients was investigated on two tests of feature selection. It was found that patients with negative symptoms (muteness, withdrawal, etc.) were characterized by an extreme lack of persistence, but selected usual features; whereas patients with positive symptoms (hallucinations, delusions, etc.) had a normal degree of persistence, but selected unusual features.