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Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study

Published online by Cambridge University Press:  08 March 2007

E. Kesse*
Affiliation:
Inserm U557 (UMR Inserm/Inra/Cnam), ISTNA-CNAM, 5 rue Vertbois, F-75003 ParisFrance
S. Bertrais
Affiliation:
Inserm U557 (UMR Inserm/Inra/Cnam), ISTNA-CNAM, 5 rue Vertbois, F-75003 ParisFrance
P. Astorg
Affiliation:
Inserm U557 (UMR Inserm/Inra/Cnam), ISTNA-CNAM, 5 rue Vertbois, F-75003 ParisFrance
A. Jaouen
Affiliation:
Inserm U557 (UMR Inserm/Inra/Cnam), ISTNA-CNAM, 5 rue Vertbois, F-75003 ParisFrance
A. Arnault
Affiliation:
Inserm U557 (UMR Inserm/Inra/Cnam), ISTNA-CNAM, 5 rue Vertbois, F-75003 ParisFrance
P. Galan
Affiliation:
Inserm U557 (UMR Inserm/Inra/Cnam), ISTNA-CNAM, 5 rue Vertbois, F-75003 ParisFrance
S. Hercberg
Affiliation:
Inserm U557 (UMR Inserm/Inra/Cnam), ISTNA-CNAM, 5 rue Vertbois, F-75003 ParisFrance
*
*Corresponding author: fax +33 153 018070, emmanuelle.kesse@cnam.fr
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Abstract

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Although dairy products have been found to be associated with an elevated risk of prostate cancer, studies investigating the potential effect of Ca are limited, and findings are inconsistent. The objective of the present study was to test the relationship between the risk of prostate cancer and consumption of dairy products and Ca. The analysis included 2776 men from the French SU.VI.MAX (Supplementation en Vitamines et Minéraux Antioxydants) prospective study, among whom sixty-nine developed prostate cancer during the follow-up period (median: 7·7 years). Food consumption was assessed at inclusion from repeated 24h records and nutrient intake was calculated using a food composition table. A higher risk of prostate cancer was observed among subjects with higher dairy product (relative risk (RR; 95% CI), 4th quartile V. 1st: 1·35 (1·02, 1·78), P=0·04) and Ca intake (RR (95% CI), 4th quartile P. 1st: 2·43 (1·05, 5·62), P=0·04). Nevertheless, we identified a harmful effect of yoghurt consumption upon the risk of prostate cancer (RR (95% CI), increment 125g/d: 1·61 (1·07, 2·43), P=0·02) independently of the Ca content. Our data support the hypothesis that dairy products have a harmful effect with respect to the risk of prostate cancer, largely related to Ca content. The higher risk of prostate cancer with linear increasing yoghurt consumption seems to be independent of Ca and may be related to some other component.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2006

References

Baron, JA, Beach, M, Wallace, K, Grau, MV, Sandler, RS, Mandel, JS, Heber, D & Greenberg, ER 2005 Risk of prostate cancer in a randomized clinical trial of calcium supplementation. Cancer Epidemiol Biomarkers Prev 14, 586589.CrossRefGoogle Scholar
Bostwick, DG, Burke, HB, Djakiew, D et al. (2004) Human prostate cancer risk factors. Cancer 101, 23712490.CrossRefGoogle ScholarPubMed
Chan, JM & Giovannucci, EL 2001 Dairy products, calcium, and vitamin D and risk of prostate cancer. Epidemiol Rev 23, 8792.CrossRefGoogle ScholarPubMed
Chan, JM, Pietinen, P, Virtanen, M, Malila, N, Tangrea, J, Albanes, D & Virtamo, J 2000 Diet and prostate cancer risk in a cohort of smokers, with a specific focus on calcium and phosphorus (Finland). Cancer Causes Control 11, 859867.CrossRefGoogle Scholar
Chan, JM, Stampfer, MJ, Ma, J, Gann, PH, Gaziano, JM & Giovannucci, EL 2001 Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study. Am J Clin Nutr 74, 549554.CrossRefGoogle ScholarPubMed
Chen, TC & Holick, MF 2003 Vitamin D and prostate cancer prevention and treatment. Trends Endocrinol Metab 14, 423430.CrossRefGoogle ScholarPubMed
Dagnelie, PC, Schuurman, AG, Goldbohm, RA & van den Brandt, PA 2004 Diet, anthropometric measures and prostate cancer risk: a review of prospective cohort and intervention studies. BJU Int 93, 11391150.CrossRefGoogle Scholar
Giovannucci, E, Rimm, EB, Wolk, A, Ascherio, A, Stampfer, MJ, Colditz, GA & Willett, WC 1998 Calcium and fructose intake in relation to risk of prostate cancer. Cancer Res 58, 442447.Google ScholarPubMed
Hercberg, S(coordinator) Table de composition SU.VI.MAX des aliments Paris: Les éditions INSERM/Economica. 2005Google Scholar
Hercberg, S, Galan, P, Preziosi, P, Bertrais, S, Mennen, L, Malvy, D, Roussel, AMFavier, A & Briancon, S 2004 The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 164, 23352342.CrossRefGoogle ScholarPubMed
Korn, EL, Graubard, BI & Midthune, D 1997 Time-to-event analysis of longitudinal follow-up of a survey: choice of the time-scale. Am J Epidemiol 145, 7280.CrossRefGoogle ScholarPubMed
Kristal, AR, Cohen, JH, Qu, P & Stanford, JL 2002 Associations of energy, fat, calcium, and vitamin D with prostate cancer risk. Cancer Epidemiol Biomarkers Prev 11, 719725.Google ScholarPubMed
Mennen, LI, Bertrais, S, Galan, P, Arnault, N, Potier de Couray, G & Hercberg, S 2002 The use of computerised 24 h dietary recalls in the French SU.VI.MAX Study: number of recalls required. Eur J Clin Nutr 56, 659665.CrossRefGoogle ScholarPubMed
Michaud, DS, Augustsson, K, Rimm, EB, Stampfer, MJ, Willet, WC & Giovannucci, E 2001 A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control 12, 557567.CrossRefGoogle ScholarPubMed
Remontet, L, Esteve, J, Bouvier, AM et al. , 2003 Cancer incidence and mortality in France over the period 1978–2000. Rev Epidemiol Sante Publique 51, 330.Google ScholarPubMed
Rodriguez, C, McCullough, ML, Mondul, AM, Jacobs, EJ, FakhrabadiShokoohi, D, Giovannucci, EL, Thun, MJ & Calle, EE 2003 Calcium, dairy products, and risk of prostate cancer in a prospective cohort of United States men. Cancer Epidemiol Biomarkers Prev 12, 597603.Google Scholar
Schuurman, AG, van den Brandt, PA, Dorant, E & Goldbohm, RA 1999 Animal products, calcium and protein and prostate cancer risk in The Netherlands Cohort Study. Br J Cancer 80, 11071113.CrossRefGoogle ScholarPubMed
Tavani, A, Gallus, S, Franceschi, S & La Vecchia, C 2001 Calcium, dairy products, and the risk of prostate cancer. Prostate 48, 118121.CrossRefGoogle ScholarPubMed
Tavani, A, Bertuccio, P, Bosetti, C, Talamini, R, Negri, E, Franceschi, S, Montella, M & La Vecchia, C 2005 Dietary intake of calcium, vitamin D, phosphorus and the risk of prostate cancer. Eur Urol 48, 2733.CrossRefGoogle ScholarPubMed
Tseng, M, Breslow, RA, Graubard, BI & Ziegler, RG 2005 Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr 81, 11471154.CrossRefGoogle ScholarPubMed
Willett, W & Stampfer, MJ 1986 Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 124, 1727.CrossRefGoogle ScholarPubMed